Protein Alignment WIPI2 and Atg18a

DIOPT Version :10

• Sequence 1: NP_056425.1
• Gene: WIPI2 / 26100
• HGNCID: 32225
• Length: 454
• Species: Homo sapiens
• Sequence 2: NP_001261565.1
• Gene: Atg18a / 38913
• FlyBaseID: FBgn0035850
• Length: 447
• Species: Drosophila melanogaster
• Alignment Length: 462
• Identity: 242/462 - (52%)
• Similarity: 309/462 - (66%)
• Gaps: 50/462 - (10%)

Human     1 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDK-L 64
            |:|..:: :..||: :|.||||:.|                  ||||.:..||..:||.|||. |
  Fly     2 MSLLGRT-DVDAGE-VFVNFNQNIT------------------SLAVATSGGYSLYSLGSVDSTL 46

Human    65 EQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL 129
            ::||. |.::::.::||||.||||||||.:||||||||||||.:|||||||:||||||||||:||
  Fly    47 DKIYH-TKSDELFLIERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERL 110

Human   130 IVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRA 194
            |||||||||||||:||||:||||:||.||.||||||.::::||||||||.|.||||:||.|||.|
  Fly   111 IVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHA 175

Human   195 ANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMD 259
            ..||||||:|||||||..|||::|||||:||||||||..:|.:|||.|||:||||||.||:||..
  Fly   176 KTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTC 240

Human   260 GMFLSASSNTETVHIFKLETVKEKPPE------EPTTWTGY-FGKVLMAS-TSYLPSQVTEMFNQ 316
            ..:|.:||||||||||:|:....:..|      ....|.|| |.:.|..: |||||:|||::|:|
  Fly   241 AEYLVSSSNTETVHIFRLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQ 305

Human   317 GRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQH--RLDGSL 379
            |||||:|.||..|.:.:|::|||||..|||:.:.|||||:|::...||.||.|:|:|  ||:...
  Fly   306 GRAFASVTLPEAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHY 370

Human   380 ETTNEILDSASHDCPLVTQTY----GAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRL 440
            ....::      |.|   ||.    |.:.|....||.|....|     ||..|....|..||:.:
  Fly   371 AMDIKV------DSP---QTLGLNSGVSIGGAAGVPPSSASAA-----GAGTGGSGGDGKSAVSV 421

Human   441 DEDSEHP 447
            ....:.|
  Fly   422 TGGVDKP 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WIPI2	NP_056425.1	WD 1. /evidence=ECO:0000255	15..60		14/44 (32%)
		WD 2. /evidence=ECO:0000255	67..104		23/36 (64%)
		WD 3. /evidence=ECO:0000255	110..142		29/31 (94%)
		WD40 repeat	120..156	CDD:293791	31/35 (89%)
		WD40	<136..360	CDD:441893	142/231 (61%)
		WD 4. /evidence=ECO:0000255	149..189		28/39 (72%)
		WD40 repeat	161..200	CDD:293791	26/38 (68%)
		WD 5. /evidence=ECO:0000255	193..232		29/38 (76%)
		WD40 repeat	206..246	CDD:293791	28/39 (72%)
		WD 6. /evidence=ECO:0000255	238..277		27/38 (71%)
		L/FRRG motif. /evidence=ECO:0000303|PubMed:24954904	241..244		1/2 (50%)
		WD40 repeat	251..284	CDD:293791	17/32 (53%)
		WD40 repeat	292..327	CDD:293791	21/36 (58%)
		WD 7. /evidence=ECO:0000255	320..359		21/38 (55%)
Atg18a	NP_001261565.1	WD40	23..269	CDD:475233	168/264 (64%)
		WD40 repeat	143..180	CDD:293791	24/36 (67%)
		WD40	<160..>271	CDD:441893	70/110 (64%)
		WD40 repeat	186..231	CDD:293791	32/44 (73%)
		WD40 repeat	232..258	CDD:293791	16/25 (64%)