DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment WIPI2 and Atg18a

DIOPT Version :9

Sequence 1:NP_056425.1 Gene:WIPI2 / 26100 HGNCID:32225 Length:454 Species:Homo sapiens
Sequence 2:NP_001261565.1 Gene:Atg18a / 38913 FlyBaseID:FBgn0035850 Length:447 Species:Drosophila melanogaster


Alignment Length:462 Identity:242/462 - (52%)
Similarity:309/462 - (66%) Gaps:50/462 - (10%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNLASQSGEAGAGQLLFANFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDK-L 64
            |:|..:: :..||: :|.||||:.|                  ||||.:..||..:||.|||. |
  Fly     2 MSLLGRT-DVDAGE-VFVNFNQNIT------------------SLAVATSGGYSLYSLGSVDSTL 46

Human    65 EQIYECTDTEDVCIVERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRL 129
            ::||. |.::::.::||||.||||||||.:||||||||||||.:|||||||:||||||||||:||
  Fly    47 DKIYH-TKSDELFLIERLFESSLVAIVSQRAPRKLKVCHFKKQSEICNYSYANTILAVKLNRERL 110

Human   130 IVCLEESLYIHNIRDMKVLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRA 194
            |||||||||||||:||||:||||:||.||.||||||.::::||||||||.|.||||:||.|||.|
  Fly   111 IVCLEESLYIHNIQDMKVVHTIRDTPCNPQGLCALSSSSEHCYLAYPGSVTAGEVQIFDAINLHA 175

Human   195 ANMIPAHDSPLAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMD 259
            ..||||||:|||||||..|||::|||||:||||||||..:|.:|||.|||:||||||.||:||..
  Fly   176 KTMIPAHDTPLAALAFSPSGTEIATASERGTVIRVFSSQDGSRLFELRRGLKRCVSIVSLSFSTC 240

Human   260 GMFLSASSNTETVHIFKLETVKEKPPE------EPTTWTGY-FGKVLMAS-TSYLPSQVTEMFNQ 316
            ..:|.:||||||||||:|:....:..|      ....|.|| |.:.|..: |||||:|||::|:|
  Fly   241 AEYLVSSSNTETVHIFRLDRSATETAEGHGSKQSSDDWMGYSFFRFLSKTVTSYLPTQVTDVFSQ 305

Human   317 GRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQH--RLDGSL 379
            |||||:|.||..|.:.:|::|||||..|||:.:.|||||:|::...||.||.|:|:|  ||:...
  Fly   306 GRAFASVTLPEAGVRRMCAIATIQKQLRLLIASQDGYLYVYSIPTVEGAECQLIKRHDLRLEDHY 370

Human   380 ETTNEILDSASHDCPLVTQTY----GAAAGKGTYVPSSPTRLAYTDDLGAVGGACLEDEASALRL 440
            ....::      |.|   ||.    |.:.|....||.|....|     ||..|....|..||:.:
  Fly   371 AMDIKV------DSP---QTLGLNSGVSIGGAAGVPPSSASAA-----GAGTGGSGGDGKSAVSV 421

Human   441 DEDSEHP 447
            ....:.|
  Fly   422 TGGVDKP 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WIPI2NP_056425.1 WD 1. /evidence=ECO:0000255 15..60 14/44 (32%)
WD40 <37..290 CDD:225201 167/259 (64%)
WD 2. /evidence=ECO:0000255 67..104 23/36 (64%)
WD 3. /evidence=ECO:0000255 110..142 29/31 (94%)
WD40 <116..231 CDD:295369 89/114 (78%)
WD40 repeat 120..156 CDD:293791 31/35 (89%)
WD 4. /evidence=ECO:0000255 149..189 28/39 (72%)
WD40 repeat 161..200 CDD:293791 26/38 (68%)
WD40 <184..363 CDD:295369 106/186 (57%)
WD 5. /evidence=ECO:0000255 193..232 29/38 (76%)
WD40 repeat 206..246 CDD:293791 28/39 (72%)
WD 6. /evidence=ECO:0000255 238..277 27/38 (71%)
FRRG motif. /evidence=ECO:0000303|PubMed:24954904 241..244 1/2 (50%)
WD40 repeat 251..284 CDD:293791 17/32 (53%)
WD40 repeat 292..327 CDD:293791 21/36 (58%)
WD 7. /evidence=ECO:0000255 320..359 21/38 (55%)
Atg18aNP_001261565.1 WD40 <15..278 CDD:225201 173/281 (62%)
WD40 23..269 CDD:295369 168/264 (64%)
WD40 repeat 143..180 CDD:293791 24/36 (67%)
WD40 repeat 186..231 CDD:293791 32/44 (73%)
WD40 repeat 232..258 CDD:293791 16/25 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 415 1.000 Domainoid score I667
eggNOG 1 0.900 - - E1_KOG2110
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H90887
Inparanoid 1 1.050 415 1.000 Inparanoid score I1840
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54442
OrthoDB 1 1.010 - - D1216824at2759
OrthoFinder 1 1.000 - - FOG0001466
OrthoInspector 1 1.000 - - otm41432
orthoMCL 1 0.900 - - OOG6_103112
Panther 1 1.100 - - LDO PTHR11227
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R106
SonicParanoid 1 1.000 - - X1186
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.910

Return to query results.
Submit another query.