Protein Alignment WIPI2 and Atg18b

DIOPT Version :10

• Sequence 1: NP_056425.1
• Gene: WIPI2 / 26100
• HGNCID: 32225
• Length: 454
• Species: Homo sapiens
• Sequence 2: NP_610100.1
• Gene: Atg18b / 35396
• FlyBaseID: FBgn0032935
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 185/396 - (46%)
• Similarity: 243/396 - (61%)
• Gaps: 53/396 - (13%)

Human    19 NFNQDNTEVKGASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERLF 83
            |||||.|                  ||:|.|.:|.:.||:||.||:|:|:...:||.:.||||||
  Fly     7 NFNQDFT------------------SLSVLSPTGLRLFSISSQDKVEEIFAKDNTEQIRIVERLF 53

Human    84 SSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMKVL 148
            :||||.:|:.:.|..||:.||||..:|||..|.:.||.|::|||||||||.||::||:|||||:|
  Fly    54 NSSLVVLVTAQKPNCLKMLHFKKKQDICNCFYPSEILCVRMNRQRLIVCLAESIHIHDIRDMKIL 118

Human   149 HTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDAS 213
            |:|....||..||||||:|:   :||:|...|.||:::|:...||....|.|||:.|:||||..|
  Fly   119 HSIENIAPNEQGLCALSLNS---HLAFPVCQTSGELRIFNASKLRTGMTIRAHDTSLSALAFSPS 180

Human   214 GTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHIFKLE 278
            |..||||||:|||||||.:..||::.||||||. ||.|.||.||..|.||.|||||||||:||::
  Fly   181 GALLATASERGTVIRVFCVKNGQRVQEFRRGVS-CVRIASLVFSASGDFLCASSNTETVHVFKID 244

Human   279 T-------------------------VKEKPPEEP----TTWTGYFGKVLMASTSYLPSQVTEMF 314
            |                         |.....||.    .:|.|.|.|.:  |:..||:||:|:.
  Fly   245 TRAVETVELKAIADVAAKSENSAKEAVASTAAEESCRPVASWGGMFSKAV--SSLLLPTQVSEVL 307

Human   315 NQGRAFATVRLPFCGHKNICSLATIQKIPRLLVGAADGYLYMYNLDPQEGGECALMKQHRLDGSL 379
            .|.|:||||:|...|.|:||:|..:||.||||:...||:||::....:.||.|.||..|.|.|:|
  Fly   308 AQDRSFATVQLAQGGLKHICALTRVQKEPRLLIACEDGFLYVHEFPAERGGPCKLMSVHDLRGAL 372

Human   380 ETTNEI 385
            |...|:
  Fly   373 EDVIEL 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WIPI2	NP_056425.1	WD 1. /evidence=ECO:0000255	15..60		13/40 (33%)
		WD 2. /evidence=ECO:0000255	67..104		17/36 (47%)
		WD 3. /evidence=ECO:0000255	110..142		20/31 (65%)
		WD40 repeat	120..156	CDD:293791	23/35 (66%)
		WD40	<136..360	CDD:441893	118/252 (47%)
		WD 4. /evidence=ECO:0000255	149..189		18/39 (46%)
		WD40 repeat	161..200	CDD:293791	16/38 (42%)
		WD 5. /evidence=ECO:0000255	193..232		25/38 (66%)
		WD40 repeat	206..246	CDD:293791	26/39 (67%)
		WD 6. /evidence=ECO:0000255	238..277		26/38 (68%)
		L/FRRG motif. /evidence=ECO:0000303|PubMed:24954904	241..244		2/2 (100%)
		WD40 repeat	251..284	CDD:293791	21/57 (37%)
		WD40 repeat	292..327	CDD:293791	16/34 (47%)
		WD 7. /evidence=ECO:0000255	320..359		20/38 (53%)
Atg18b	NP_610100.1	WD40 repeat	79..122	CDD:293791	27/42 (64%)
		WD40 repeat	130..166	CDD:293791	16/38 (42%)
		WD40	<149..>251	CDD:441893	59/102 (58%)
		WD40 repeat	172..208	CDD:293791	22/35 (63%)
		WD40 repeat	212..257	CDD:293791	23/45 (51%)