Protein Alignment GGA1 and CG3529

DIOPT Version :10

• Sequence 1: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_648315.1
• Gene: CG3529 / 39093
• FlyBaseID: FBgn0035995
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 129/564 - (22%)
• Similarity: 221/564 - (39%)
• Gaps: 103/564 - (18%)

Human    13 RINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKI-QSPQEWEAIQALTVRRGEATI 76
            ||..||:......:||:....|:.:||..:....|.|.:..:: |:..:...:...|:
  Fly    21 RIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL------- 78

Human    77 RPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTV 141
                    .|||||:|:|||.||..|.:..|:|||:|::.||   :.....::.|:|.|:..|..
  Fly    79 --------TVLETCVKNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWAD 132

Human   142 GL---PEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSH 203
            ..   |:...:.:.|..||.:||  ..|....|...|:..|: ::|   .|...:::|....:..
  Fly   133 AFKNQPDLNGVTQMYMELKNKGI--EFPANDLDAMAPIYTPQ-RSV---PEMPPQLVAAQQHTIS 191

Human   204 PEDLRAANKLIKEMVQEDQK-----RMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSE 263
            |:.:.||.............     ..|:.:|..:.:|.|:||:.:|:|| :|..:.|..:....
  Fly   192 PQHMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEM-LSVLKPGQESPDDY 255

Human   264 DLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGS 328
            .|:.||...|:.|:..:..|....:| ||..||.|:.||.|..|      .:|.:....:.:.|.
  Fly   256 ALLNELTSTCKEMQSRIVDLIGRVQD-DELTAEFLRINDELNNV------FLRHQRYEKNRSQGQ 313

Human   329 IPGSTS------ALLDLSGLDLPPAG-TTYPAMPTRPGEQASPEQPSASVSLLD----------- 375
            ..|.||      |.:.|.|:....|| ||...:|..|...|....|.:...|:|
  Fly   314 GAGVTSPSAVLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLP 378

Human   376 DELMSLGLSDPTP--------PSG----------------------PSLDGTGWNSFQSSDATEP 410
            ..|..:.|....|        |:.                      ||:|....:...::...:|
  Fly   379 QSLGQISLGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKP 443

Human   411 PAPALAQAPSMESRPPAQTSLPASSGLDDLDL-LGKTL---LQQSLPPESQQVRWEKQQPTPRLT 471
            ..|..||..:.|  ||..:.....:.:|:::. ||.:.   :::....|..:...|:......|.
  Fly   444 NQPQQAQRSAGE--PPVVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDKFLEERAAAAENLP 506

Human   472 LRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLA 515
            .....|.::|.::.|:.|.||..|        |::|...|..||
  Fly   507 TISASNSAASATTGSAGADSLRKT--------PKKPGAEEDLLA 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGA1	NP_001350700.1	VHS_GGA1	9..164	CDD:340806	42/154 (27%)
		GGA_N-GAT	186..224	CDD:465702	5/42 (12%)
		GAT_GGA1_GGA2	227..315	CDD:410586	26/87 (30%)
		Alpha_adaptinC2	534..648	CDD:197886
CG3529	NP_648315.1	VHS_Tom1_like	17..154	CDD:340768	40/150 (27%)
		GAT_TOM1_like	222..307	CDD:410581	27/92 (29%)