Protein Alignment GGA1 and Stam

DIOPT Version :10

• Sequence 1: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 149/787 - (18%)
• Similarity: 238/787 - (30%)
• Gaps: 300/787 - (38%)

Human    11 EARINRATNPLNKELDWASINGFCEQLNEDFEGPPLA---TRLLAHKIQSPQEWEAIQALTVRRG 72
            :|.:.:||:..|...:|:.|...|:::..:   |.||   .:.:..::........:||:|
  Fly    11 DADVEKATSETNTNDNWSLILDVCDKVTTN---PRLAKDCLKAVMRRMGHTDPHVVMQAIT---- 68

Human    73 EATIRPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNE---LIKVVSPKY--------------- 119
                         :|:....:|||..|.||....|..|   |:....||.
  Fly    69 -------------LLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLKNWAEND 120

Human   120 --------------------------LGSRTSEKVKNKILELLYSWTVGLP----------EEVK 148
                                      ||.:||:.|..|        ...||          ||..
  Fly   121 YKNDRELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEK--------AAALPKDPNVVSSQQEEDD 177

Human   149 IAEAYQMLKKQGIVKSDPK--------------------------LPDDTTFPLPPPRPKNV--- 184
            ||:|.::..|:.  |..||                          .|.......|.|.|:.|
  Fly   178 IAKAIELSLKEN--KGSPKTGSVASTGTASAYPSLYPSFAGTGSSAPSAEASSAPAPEPRKVRAL 240

Human   185 -IFEDEEKSKM------LARLLKSSHP----------EDLRAANKLIKEMVQEDQKRMEKISKRV 232
             .||..|::::      :..:|..|.|          |.|..:|.:..:: ..|.:|::...:..
  Fly   241 YDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADL-SVDPERLDINQQHK 304

Human   233 NAI----EEVNNNVKLLTEMVMSHSQGGAAAGSSE----------------------------DL 265
            :|.    .|:::...|     ...::..|||.:::                            |.
  Fly   305 SAAAAGQRELDSAAAL-----QQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEANPEDPSQDSDE 364

Human   266 MKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGD----ATA 326
            |.:|.|...:|.|.   :.::.|..|...|::.|.:.:|...||||..|:|.:.....    |..
  Fly   365 MLQLEQEVHQMGPL---IDAELERVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAG 426

Human   327 GSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSG 391
            |.:||       |:|.   |....|.|    ||..|:...|
  Fly   427 GFMPG-------LAGF---PGAALYGA----PGYPAAGGFP------------------------ 453

Human   392 PSLDGTGWNSFQSSDATEPPAPALAQAPSME----SRPPAQTSLPASSGLDDLDLLGKTLLQQSL 452
            |:.:..|.:|........||..|.:|||...    .:|..|..||..:        |......||
  Fly   454 PAQNYPGMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQN--------GHAAQMNSL 510

Human   453 PPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPE-PPRPPQQPVPTELSLAS 516
            |....|.......|.|..|            .|:...|.......|: |.:||||
  Fly   511 PAHLTQPTGTAPMPQPIYT------------QPTPVTTQQQQQPLPQHPQQPPQQ---------- 553

Human   517 ITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAV 581
                 :..:|..      :.|:.:.|      ||....:.| ...|:.:....||.....:.|
  Fly   554 -----QGQQPPQ------HPQNSYHI------DPQSQYAQV-PPAVTQIQQPQQPPAPHAYMS-- 598

Human   582 PKVMKVKLQPPSGTELPA---FNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGD 643
            |:..:.  .||.|.: |.   :.|...|:.:       |||.           .|..|...:
  Fly   599 PQHQQA--PPPQGYQ-PGPNLYGPNGSPAVV-------NPQS-----------YMSPQQQQQ--- 639

Human   644 VDQFPPP 650
              |.|||
  Fly   640 --QHPPP 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGA1	NP_001350700.1	VHS_GGA1	9..164	CDD:340806	39/209 (19%)
		GGA_N-GAT	186..224	CDD:465702	10/53 (19%)
		GAT_GGA1_GGA2	227..315	CDD:410586	21/119 (18%)
		Alpha_adaptinC2	534..648	CDD:197886	22/116 (19%)
Stam	NP_477448.1	VHS_STAM	10..141	CDD:340770	25/149 (17%)
		SH3_STAM	235..288	CDD:212754	10/52 (19%)
		GAT_STAM	337..413	CDD:410593	16/78 (21%)
		PHA03247	<436..526	CDD:223021	26/125 (21%)