Protein Alignment GGA1 and Gga

DIOPT Version :10

• Sequence 1: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_572571.1
• Gene: Gga / 31902
• FlyBaseID: FBgn0030141
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 189/687 - (27%)
• Similarity: 315/687 - (45%)
• Gaps: 113/687 - (16%)

Human    10 LEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVRRGEA 74
            :|..:.|||||..| :|...:..||..:..:.:....|..::..|::|....||.:|::
  Fly     8 MEEMLERATNPAQK-IDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAIS------ 65

Human    75 TIRPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSW 139
                       :||.||..||..|.||..|||||||||::||.||.|:.|..:||.:|:|.|..|
  Fly    66 -----------LLEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHEVKQRIMECLLLW 119

Human   140 TVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHP 204
            |...|:..||.:||.||:|:|.:       :..|......:.::|:...:|  .|.|:|:||::|
  Fly   120 TTEFPQRQKIRDAYDMLRKEGDI-------EHGTTEAAVAKRESVLGTIDE--AMFAKLIKSNNP 175

Human   205 EDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKEL 269
            |:.:.||.|::..:.::.:|.:.:::....:.||...::||.:|:.::.   .|.....:.:.||
  Fly   176 ENFKRANLLLQYRMAQEARRNDLLAQHRLVLCEVQETMQLLNQMLDTYD---PANQDVSETLHEL 237

Human   270 YQRCERMRPTLFRLASDTEDND-EALAEILQANDNLTQVINLYKQLVRGEEVNGDA--------- 324
            |:.|::.:|....|....:|:| :.:|:.|.||..|...:..||.||.....:..|
  Fly   238 YKSCKKHKPIFQHLPQLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTV 302

Human   325 ------TAGSIPGSTSA-----LLDLSGLDL-----PPAGTTYPAMPTRPGEQASPEQPSASVSL 373
                  ||.|...:||:     |.:|.| ||     ..|.||  |..:.|...||...|.|.:|
  Fly   303 ASSVKSTASSTTATTSSNNAQLLNELLG-DLLIDGSNKAATT--ATTSLPNAAASGSNPLADLS- 363

Human   374 LDDELMSLGLSDPTPPSGPSLDGTGWNSFQ-SSDATEPPAPALAQAPSMESRPPAQTSLPASSGL 437
             |....:|..|:....|.|..:.|.....| .|..|...|.|.....|....|.....:|
  Fly   364 -DIFSSALAESEAKQQSQPFQNATTLLEPQVISQGTTTEALANGNGGSASKVPETIRKMP----- 422

Human   438 DDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDL---------------QNKSSSCSSPS- 486
             .:|:|.:.|.||.||.:.:...: |:.| .::||.||               .|..:|.|:|:
  Fly   423 -QIDMLSEELFQQILPTQDRMPSF-KRDP-EKITLNDLARERMHIKAPEEPTTANDPASDSAPAI 484

Human   487 SSATSLLHT------------------VSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVT 533
            ::||:.:.:                  |:|....||.:|      |:.|.|.|::|:.:....:
  Fly   485 ATATATVDSIDDVPLLSDDVEKKDEAVVAPVTVVPPAKP------LSEINVELDNIQATGEQRI- 542

Human   534 VYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELP 598
            |.|....::..:|..| .||.. |.|:|:|..:.:.||:|:..|:::|.|..||:|..|:.:::|
  Fly   543 VLDDDDMQLSLNFTSD-RPGHR-VSVIVISAQNKSRQPVRDFQFEASVKKPCKVRLLTPTDSQMP 605

Human   599 AFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGD 635
            ...|....:.|.||:||.||..:.|.:...:.:.:||
  Fly   606 PHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGA1	NP_001350700.1	VHS_GGA1	9..164	CDD:340806	56/153 (37%)
		GGA_N-GAT	186..224	CDD:465702	11/37 (30%)
		GAT_GGA1_GGA2	227..315	CDD:410586	21/88 (24%)
		Alpha_adaptinC2	534..648	CDD:197886	32/102 (31%)
Gga	NP_572571.1	VHS_GGA_metazoan	8..144	CDD:340769	56/160 (35%)
		GAT_GGA_meta	201..283	CDD:410582	21/84 (25%)
		Alpha_adaptinC2	543..644	CDD:197886	32/102 (31%)