DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGEF26 and Exn

DIOPT Version :9

Sequence 1:NP_001238891.1 Gene:ARHGEF26 / 26084 HGNCID:24490 Length:871 Species:Homo sapiens
Sequence 2:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster


Alignment Length:947 Identity:257/947 - (27%)
Similarity:415/947 - (43%) Gaps:182/947 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     2 DGESEV---DFSSNSITPLWRRRSIPQP-------HQVLGRSKPRPQSYQSPNGLLITDFPVEDG 56
            |||.::   :::.:.:.  .|...:|:|       ::.:.:.|....|.:||.|.....:.....
  Fly  1169 DGEPDLRQRNYNDSGVD--MRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPA 1231

Human    57 GTLLAAQI--------------PAQVPTASDSRTVH--RSPLLLGAQRRAVANGGTASPEYRAAS 105
            .||...:.              |.::|.......||  ::|:|...|:    ||       ::..
  Fly  1232 STLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQK----NG-------KSLR 1285

Human   106 PRLRRP------KSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTPNA--------PAPC 156
            .|||:.      .:.:|....|..|.....:...:|||.|..|.:......::        |.|.
  Fly  1286 SRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPE 1350

Human   157 TPEEDLTGLTASPVPSP----TANGLAANNDSPGSGSQSGRKAK-DPERGLFPGPQKSSSEQKLP 216
            ||:.......|......    |..||..|:..|.....:|.|:. ||||.|       .:||   
  Fly  1351 TPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPEREL-------DAEQ--- 1405

Human   217 LQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSM 281
                               :|:..|...|.||       |:...:|...::.|.|          
  Fly  1406 -------------------TTSWYAECGVFKQ-------ATNGAVSPRGDEPVTP---------- 1434

Human   282 VEGLGGPLGHAGEES-EVDNDVDSPGSLRRGLRSTSYRRAVVSGFDF---DSPTSSKKKNRMSQP 342
                 .|.||.|..| ..::.:.....:  .:.|:|....|.:|.:.   |..:|.......::|
  Fly  1435 -----TPSGHGGVSSWYAESGLYQTSGI--SVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEP 1492

Human   343 VLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKI 407
            :.:  |....|..|:.|    .|:..|:.||         |:|..|...:..|...|.:.:..::
  Fly  1493 LYQ--MYSAAKLESITR----DLEAHGSSDG---------YEEIGLQAKAKPEPLVKPRPTALQL 1542

Human   408 V-IHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKEL 471
            | ..:.|.|:.||::..|....:..|::..||..|||.||:|:||.|||.||.:|.|.|.|....
  Fly  1543 VEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAF 1607

Human   472 SDT--MTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDIS----DIVEKHTASTFDPYV 530
            .|:  ::..:|..|||.|..|.|.|::...||||..|:||.:..:|    :|.|:|    |..||
  Fly  1608 LDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERH----FHVYV 1668

Human   531 KYCTNEVYQQRTLQKLLATNPS--FKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTIC 593
            .:|.::....|||::|..:..|  |::.|.|:|:...|..|.:.|||:|||||:||||||:|.:.
  Fly  1669 AFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVF 1733

Human   594 QK-TPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEF-------KIKPFPLV 650
            .| :|.:..:||..|..|..|.|:|..|||.|.:.|:...:..|..||||       .|.|..:.
  Fly  1734 SKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVP 1798

Human   651 ---SSSRWLVKRGELTAYV---EDTVL-FSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSL 708
               :..|:||||||||..:   ||..| |.:|.:|..:|.|||:|:|::.|::.|..::|.||..
  Fly  1799 RAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCP 1863

Human   709 RDQLLVESCDN------EELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQ 767
            |..|.:.:.|:      ::|....|||              |..:|:|.|...:.||::|...:.
  Fly  1864 RSMLTLAAGDSLPQLPTKDLKDQAGKN--------------LILMTLLENCDRKTVELVLSCPSV 1914

Human   768 SERARWITALGHSSGKPPADRT----SLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYE 828
            |::.||:.|:.....:.|.::.    ...||....|:.:.:||.|.|::.|||.:.:::.||||:
  Fly  1915 SDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQ 1979

Human   829 GERLRDGERGWFPMECAKEITCQATIDKNVERMGRLL 865
            |||:|||..||||....:|:.......:|:::..|||
  Fly  1980 GERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRLL 2016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGEF26NP_001238891.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49 11/56 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..233 33/165 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..310 5/22 (23%)
RhoGEF 443..622 CDD:279015 75/187 (40%)
PH_ephexin 643..781 CDD:269929 46/150 (31%)
SH3_ARHGEF16_26 793..847 CDD:212871 24/53 (45%)
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 74/185 (40%)
PH_ephexin 1805..1931 CDD:269929 44/139 (32%)
SH3_ephexin1_like 1944..1998 CDD:212727 24/53 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I5908
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41472
orthoMCL 1 0.900 - - OOG6_105893
Panther 1 1.100 - - O PTHR12845
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.810

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