DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and DDX3Y

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001116137.1	Gene:	DDX3Y / 8653	HGNCID:	2699	Length:	660	Species:	Homo sapiens

Alignment Length:	620	Identity:	264/620 - (42%)
Similarity:	357/620 - (57%)	Gaps:	86/620 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RGGGAGGYRGG--------NRDGG-GFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGG 120
            :.|||.....|        ||:.. |||      ::|..|.... :.....|..|...|||..|.
Human    26 QSGGASTASKGRYIPPHLRNREASKGFH------DKDSSGWSCS-KDKDAYSSFGSRDSRGKPGY 83

  Fly   121 FRGGEGGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFAR--RRRNED 183
            |.....|.|||.       :.|||.|.:..|...|....|.||.|.         :|  .:..||
Human    84 FSERGSGSRGRF-------DDRGRSDYDGIGNRERPGFGRFERSGH---------SRWCDKSVED 132

  Fly   184 DINNNNNIVEDVERKREFYIPPEPSNDAI--EIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQH 246
            |                 :..|.|.::.:  |:||.| .:||:|.||::|||:.|||:.|..|::
Human   133 D-----------------WSKPLPPSERLEQELFSGG-NTGINFEKYDDIPVEATGSNCPPHIEN 179

  Fly   247 FTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLED- 310
            |:..|:.:||:.|:..:.|..|||:||.:||:|...|||||||||||||||||||||||::..|
Human   180 FSDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDG 244

  Fly   311 PHEL-----ELGR-------PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNE 363
            |.|.     |.||       |..::::||||||:||:.|||||::.|.::..:||||.....|..
Human   245 PGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIR 309

  Fly   364 CITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPE--H 426
            .:.||||:::||||||:|.::|..|..:..:::|||||||||||||...:|||:...||.|:  .
Human   310 DLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVR 374

  Fly   427 QTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQADG 491
            .|:|||||||:|||.:|.:||..|:|:|:|.||....::.|.:..|....|||.|::||.  |.|
Human   375 HTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDKRSFLLDILG--ATG 437

  Fly   492 ----TIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRG 552
                |:||||||:|||.|..||..:.:..|||||||.|..||:||..|::|...:|:||:||:||
Human   438 SDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARG 502

  Fly   553 LDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVP 617
            |||.|::||||:|:||.|::|||||||||||||.|.|||||: ||:..|..||:.:|..:.|.||
Human   503 LDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFN-EKNMNITKDLLDLLVEAKQEVP 566

  Fly   618 DFLRTCG-----AGGDGGYSNQN-----FGGVDVR 642
            .:|....     .||..|.|..|     ||..|.|
Human   567 SWLENMAYEHHYKGGSRGRSKSNRFSGGFGARDYR 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	111/221 (50%)
		DEXDc	260..467	CDD:214692	110/221 (50%)
		Helicase_C	475..584	CDD:278689	64/112 (57%)
DDX3Y	NP_001116137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..121		31/108 (29%)
		PTZ00424	171..554	CDD:185609	196/385 (51%)
		Q motif	178..206		9/27 (33%)
		DEADc	180..402	CDD:238167	111/221 (50%)
		DEAD box	345..348		2/2 (100%)
		Helicase_C	424..534	CDD:278689	64/111 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..625		9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820