DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and DBP10

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_010253.2	Gene:	DBP10 / 851530	SGDID:	S000002189	Length:	995	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	159/542 - (29%)
Similarity:	248/542 - (45%)	Gaps:	112/542 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 GERRGRLDREERGGERGERGDGGFARRRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAIEIFS 216
            |.::.:.|.|::.....|..|..|  ...||..:|::.:...|.:.:.|....|....|.|| :|
Yeast     3 GVQKRKRDLEDQDDNGSEEDDIAF--DIANEIALNDSESDANDSDSEVEADYGPNDVQDVIE-YS 64

  Fly   217 SGIASGIHFSK----------------------------YNNIPVKV-TGSDVPQPIQHFT---- 248
            |....|::..|                            .||...|. ||.|.....::|:
Yeast    65 SDEEEGVNNKKKAENKDIKKKKNSKKEIAAFPMLEMSDDENNASGKTQTGDDEDDVNEYFSTNNL 129

  Fly   249 -----------SADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLP 302
                       |..|..|:::|:.:.|::.|||||:.:||:|...||::..|:|||||||||:||
Yeast   130 EKTKHKKGSFPSFGLSKIVLNNIKRKGFRQPTPIQRKTIPLILQSRDIVGMARTGSGKTAAFILP 194

  Fly   303 ILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITR 367
            ::.||  ..|..::| .:.||:||:||||:|.||..:.||..:.|:..::.||.|...|...:..
Yeast   195 MVEKL--KSHSGKIG-ARAVILSPSRELAMQTFNVFKDFARGTELRSVLLTGGDSLEEQFGMMMT 256

  Fly   368 GCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQTLMFS 432
            ...|:||||||.|.......:..:...:||.|||||:.:|||.|.:..::  .::....|||:||
Yeast   257 NPDVIIATPGRFLHLKVEMNLDLKSVEYVVFDEADRLFEMGFQEQLNELL--ASLPTTRQTLLFS 319

  Fly   433 ATFPEE-------------IQRMAGE----------FL--KN--------YVFVAIGIVGGACSD 464
            ||.|..             :.|:..|          ||  ||        |:...|..:..|.|:
Yeast   320 ATLPNSLVDFVKAGLVNPVLVRLDAETKVSENLEMLFLSSKNADREANLLYILQEIIKIPLATSE 384

  Fly   465 VKQTIYEVNKYA-----------------KRSKL--------IEILSEQADGTIVFVETKRGADF 504
            ..|.:...|..|                 |:.|.        .|:.||:|  ||:||.|:...::
Yeast   385 QLQKLQNSNNEADSDSDDENDRQKKRRNFKKEKFRKQKMPAANELPSEKA--TILFVPTRHHVEY 447

  Fly   505 LASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSK 569
            ::..|.:..:..:.|:|...|..|::.|.:|:.|...:|:.|.||:||:||..:.:||||.:|..
Yeast   448 ISQLLRDCGYLISYIYGTLDQHARKRQLYNFRAGLTSILVVTDVAARGVDIPMLANVINYTLPGS 512

  Fly   570 IDDYVHRIGRTGRVGNNGRATS 591
            ...:|||:|||.|.||.|.|.|
Yeast   513 SKIFVHRVGRTARAGNKGWAYS 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	84/254 (33%)
		DEXDc	260..467	CDD:214692	82/239 (34%)
		Helicase_C	475..584	CDD:278689	40/133 (30%)
DBP10	NP_010253.2	SrmB	110..649	CDD:223587	138/432 (32%)
		DEADc_DDX54	137..341	CDD:350717	76/208 (37%)
		DBP10CT	820..880	CDD:400455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910