DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and Tdrd12

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_038956788.1	Gene:	Tdrd12 / 689639	RGDID:	1562792	Length:	1314	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	95/428 - (22%)
Similarity:	164/428 - (38%)	Gaps:	73/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 SADLRDIIIDNVNKSGYKIPTPIQKCSI--PVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDP 311
            ||||:..:..|      |.|.|....|.  |.|:.|.|::..:..|: ....:|.|:|:
  Rat   430 SADLKKALQRN------KFPGPSHTASYSWPPIARGCDVVVISHCGN-DPLLYLPPLLT------ 481

  Fly   312 HELELG----------RPQVVIVSPTRELAIQIFNEARKFAFES------YLKIGIVYGGTSFRH 360
             .|::|          .|..|||.|..:.|..||.....::..|      .|.||:        |
  Rat   482 -ILQMGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPVLLTIGL--------H 537

  Fly   361 QNEC----ITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVT 421
            ::|.    :.|||.|::.||..||..:....:.|.....:||||. .:|....:|.|..|:.:..
  Rat   538 KDEAKNMKLPRGCDVIVTTPHSLLRLLTYRSLLFLRLCHLVLDEV-HVLFFEANEQMFAILDNFK 601

  Fly   422 MRPE--------HQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGAC-SDVKQTIYEVNKYAK 477
            ...|        ||.:.....:...|:.:..||:|:...|...:...|. ..|:|.::...:..|
  Rat   602 KNVEVEERESAPHQIVAVGVHWNRHIEHLVREFMKDPHVVITALEEAALYGSVQQVVHLCLECEK 666

  Fly   478 RSKLIEILS---EQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGD---RLQSQREQALRDFK 536
            .|.|:::|.   .||..|::|..:....:.:...:.........:|.:   .|:|..||..:...
  Rat   667 TSTLLQVLDFVPSQAQKTLIFTCSVAETEIVCKVVESNSIFCLKMHKEMAFNLKSILEQWKKKLS 731

  Fly   537 NGSMKVLIATSVASRGLDIKNIKHVINYDMPSK----------IDDYVHRI---GRTGRVGNNGR 588
            :||..||..|......|.|.:...|:::..||.          :.|:...:   |.....|....
  Rat   732 SGSHIVLTLTDDCIPLLAITDATCVVHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSPAEQGGKKT 796

  Fly   589 ATSFFDPEKDRAIAADLVKILEGSGQTVPDFLRTCGAG 626
            .:.....|::.:.|..:::.||.:...:|..|....||
  Rat   797 KSVLLLTERNASHAVGVLRYLERADAKIPSELYEFTAG 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	57/234 (24%)
		DEXDc	260..467	CDD:214692	55/237 (23%)
		Helicase_C	475..584	CDD:278689	25/127 (20%)
Tdrd12	XP_038956788.1	Tudor_TDRD12_rpt1	13..171	CDD:410505
		SrmB	428..862	CDD:223587	95/428 (22%)
		Tudor_TDRD12_rpt2	900..1022	CDD:410506
		p23_like	1179..1254	CDD:107220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910