DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and Ddx59

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_080776.1	Gene:	Ddx59 / 67997	MGIID:	1915247	Length:	619	Species:	Mus musculus

Alignment Length:	390	Identity:	148/390 - (37%)
Similarity:	230/390 - (58%)	Gaps:	13/390 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 VKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTA 297
            :.|.|.||.:||..|......:.:..|:.||||::|||||...|||...|||::|.|.|||||||
Mouse   191 ISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTA 255

  Fly   298 AFLLPILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARK-FAFESYLKIGIVYGGTSFRHQ 361
            |||||::.:...:..     .|..:|::|||||||||..:|:: .:....:|..::.||.....|
Mouse   256 AFLLPVIIRAFSEDK-----TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQ 315

  Fly   362 NECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEH 426
            ...:.:...|:|||||||||.:.::.::....:.||:||||.||.|||.:.:..::.|..  .:.
Mouse   316 LYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADTMLKMGFQQQVLDVLEHTP--GDC 378

  Fly   427 QTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQ--- 488
            ||::.|||.|:.|:::..:.|.|.|.:..|.....|:.|:|.|..|...||:.||.|||::|
Mouse   379 QTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPCASVRQIILWVEDPAKKKKLFEILNDQKLF 443

  Fly   489 ADGTIVFVETKRGADFLASFLSE-KEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRG 552
            ....:|||:.|.|||.|:..:.: ....:||||.::.|.:|...|:....|..:|:::|.|..||
Mouse   444 KPPVLVFVDCKLGADLLSEAVQKITGLNSTSIHSEKSQVERRDILKGLLEGDYEVVVSTGVLGRG 508

  Fly   553 LDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVP 617
            ||:.|:|.|:|:||||.:|:|||::||.||:|.||.|.:|.:....| :..|:.|.::.:|..:|
Mouse   509 LDLVNVKLVVNFDMPSSMDEYVHQVGRVGRLGQNGTAITFINNNSKR-LFWDVAKRVKPTGSILP 572

Fly 618 617
Mouse 573 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	79/207 (38%)
		DEXDc	260..467	CDD:214692	80/207 (39%)
		Helicase_C	475..584	CDD:278689	47/112 (42%)
Ddx59	NP_080776.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		PLN00206	70..593	CDD:215103	148/390 (38%)
		Q motif	203..231		10/27 (37%)
		DEAD box	353..356		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910