DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and ddx10

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001096151.1	Gene:	ddx10 / 613047	XenbaseID:	XB-GENE-985914	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	138/447 - (30%)
Similarity:	216/447 - (48%)	Gaps:	51/447 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 INNNNNIVEDVERKREFYI--------------PPE--PSNDAIEIFSSGIASGIHFSKYNNIPV 233
            ||:.|:.|::.|:.::.|.              .||  ...:.|.....      .:|:.|...:
Frog    14 INSRNDPVKNFEKWKKKYSKKKEKCKSHRKQNKKPEWQVEKETITRLEQ------RYSEINTSEI 72

  Fly   234 KVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAA 298
             |..||.|     .:...||.::     :..|::||.|||.:|.:...|:|::..|:||||||.|
Frog    73 -VKFSDFP-----LSKKTLRGLV-----EGQYRLPTEIQKQTIGLALQGKDVLGAAKTGSGKTLA 126

  Fly   299 FLLPILSKLLEDPHELE--LGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQ 361
            |::|.|..|.......:  ||   |:|:|||||||.|.|...||.........|:|.||...:.:
Frog   127 FIIPALECLYRQQWTSDDGLG---VLIISPTRELAYQTFEVLRKVGRNHEFSAGLVIGGKDLKQE 188

  Fly   362 NECITRGCHVVIATPGRLLDFVDRTFITF--EDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRP 424
            ..||.| .:::|.||||||..:|.| .||  .:.:.:|||||||:|||||::.|..|:.::..:
Frog   189 TACIHR-TNILICTPGRLLQHMDET-STFHASNLQMLVLDEADRILDMGFADTMNAIVENLPKK- 250

  Fly   425 EHQTLMFSATFPEEIQRMAGEFLKN--YVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIE--IL 485
             .|||:||||..:.::.:|...||:  ||:|.........:.::|. |.|.:..::..|:.  |.
Frog   251 -RQTLLFSATQTKSVKDLARLSLKDPEYVWVHENAKFSTPATLEQN-YVVCELQQKINLLYSFIR 313

  Fly   486 SEQADGTIVFVETKRGADFL--ASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSV 548
            :.....:|||..:.:...:|  |........|...:||.:.|.:|.:...||......||.||.:
Frog   314 NHLKKKSIVFFSSCKEVQYLFRAFCRLRPGIPVLVLHGKQQQMKRMEVYNDFIRKKSAVLFATDI 378

  Fly   549 ASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADL 605
            |:||||...:..|:..|.|...:.|:||:|||.|....|.|.....|.:.:.:...|
Frog   379 AARGLDFPAVNWVLQLDCPEDANTYIHRVGRTARYKEGGEALLVLLPSEVKGMFKQL 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	82/212 (39%)
		DEXDc	260..467	CDD:214692	81/212 (38%)
		Helicase_C	475..584	CDD:278689	33/112 (29%)
ddx10	NP_001096151.1	SrmB	52..564	CDD:223587	130/409 (32%)
ddx10	NP_001096151.1	60KD_IMP	<704..798	CDD:321001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910