DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and DDX19A

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_060802.1	Gene:	DDX19A / 55308	HGNCID:	25628	Length:	478	Species:	Homo sapiens

Alignment Length:	395	Identity:	116/395 - (29%)
Similarity:	199/395 - (50%)	Gaps:	52/395 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 NNIPVKVTGSDVPQP---IQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVI--SSGRDLMAC 288
            |...|:|...|...|   ::.|....|:..::..|...|:..|:.||:.::|::  ...::|:|.
Human    72 NTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQ 136

  Fly   289 AQTGSGKTAAFLLPILSKLLEDPHELELGRPQVVIVSPTRELAIQ---IFNEARKFAFESYLKIG 350
            :|:|:||||||:|.:||::  :|.:   ..||.:.:|||.|||:|   :..:..||..|  ||:.
Human   137 SQSGTGKTAAFVLAMLSRV--EPSD---RYPQCLCLSPTYELALQTGKVIEQMGKFYPE--LKLA 194

  Fly   351 IVYGGTSFRHQNECITRGCHVVIATPGRLLDFVDR-TFITFEDTRFVVLDEADRML-DMGFSEDM 413
            ....|.......:...:   :||.|||.:||:..: .||..:..:..||||||.|: ..|..:..
Human   195 YAVRGNKLERGQKISEQ---IVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQS 256

  Fly   414 RRIMTHVTMRPEH-QTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKY-- 475
            .||.   .|.|.: |.|:|||||.:.:.:.|.:.:.:...:.:       ...::|:..:.:|
Human   257 IRIQ---RMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKL-------KREEETLDTIKQYYV 311

  Fly   476 --AKRSKLIEILSE--------QADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQ 530
              :.|.:..:.|..        ||   ::|..|::.|.:||:.||::......:.|:.:..||..
Human   312 LCSSRDEKFQALCNLYGAITIAQA---MIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAA 373

  Fly   531 ALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKID------DYVHRIGRTGRVGNNGRA 589
            .:..|:.|..|||:.|:|.:||:|::.:..|||:|:|...|      .|:||||||||.|..|.|
Human   374 VIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLA 438

  Fly   590 TSFFD 594
            .:..|
Human   439 VNMVD 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	66/214 (31%)
		DEXDc	260..467	CDD:214692	64/214 (30%)
		Helicase_C	475..584	CDD:278689	40/126 (32%)
DDX19A	NP_060802.1	N-terminal lobe. /evidence=ECO:0000250	2..299		71/246 (29%)
		N-terminal helix. /evidence=ECO:0000250	54..67
		DEAD-like_helicase_N	74..302	CDD:391939	70/247 (28%)
		Q motif	91..119		6/27 (22%)
		DEAD box	241..244		2/2 (100%)
		C-terminal lobe. /evidence=ECO:0000250	300..478		45/147 (31%)
		SF2_C_DEAD	306..442	CDD:350174	43/138 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910