DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and ddx4

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_012818309.1	Gene:	ddx4 / 549577	XenbaseID:	XB-GENE-1016809	Length:	678	Species:	Xenopus tropicalis

Alignment Length:	707	Identity:	306/707 - (43%)
Similarity:	415/707 - (58%)	Gaps:	75/707 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDDWDDE---------PIVDTRGARGGD----WSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQG 52
            |.::||.|         |...:......|    :|:::.|.:::..|......||...|.||...
Frog     1 MEENWDTEISTEKPTYIPNFSSLETDNTDNYTAYSNNDITNQNYQSERSFGNRGGYRSERGGPTN 65

  Fly    53 GNRDVFGRIGGGRGGGAG---GYR-GGNRDGGGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGG 113
            .||.  .|||.|||..:.   .|. ...|||   :....:.::.|| |.||||...|..||
Frog    66 FNRG--SRIGRGRGFDSNRNDQYSDSSERDG---YNANEDTQKPFR-GRGGFRNENGQRRG---- 120

  Fly   114 SRGGQGGFRGGEGGFRGRLYENEDGDER---RGRLDREERGGER-----RG---RLDREERG-GE 166
             .|.:||||            ||:|.:|   ||..:....|.||     ||   ..|.:..| |.
Frog   121 -FGDRGGFR------------NENGQQRNFDRGDWNNSGEGEERPRGFGRGGFNNFDSDTGGRGH 172

  Fly   167 RGERGDGGFARRRRNEDDINNNNNIVEDVER--KREFYIPPEPSNDAIEIFSSGIASGIHFSKYN 229
            ||.||..|..:.|..|..:.:..|..|..|:  |:..|:|..||:...:||.. ..|||:|.||:
Frog   173 RGGRGGRGGYKGRNEEVGVESGKNQEEGTEKEVKKVIYVPLPPSDSEDDIFRH-YQSGINFDKYD 236

  Fly   230 NIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSG 294
            .|.|.|||.|||..|..|..|:..:.:..||.|:||...||:||.|||:|.:|||||||||||||
Frog   237 EILVDVTGKDVPPAILTFEEANFCETLSRNVTKAGYVKLTPVQKHSIPIILAGRDLMACAQTGSG 301

  Fly   295 KTAAFLLPILSKLLED----PHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGG 355
            |||||||||||.::.:    ...|.|..||.:|::|||||..||:.:||||::.:.::..:||||
Frog   302 KTAAFLLPILSHMMNEGITASQFLPLQEPQAIIIAPTRELINQIYLDARKFSYGTCVRPVVVYGG 366

  Fly   356 TSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHV 420
            ....|....:.|||:::.||||||:|.:.|..|.....:::|||||||||||||:..|..::...
Frog   367 IHPVHAMRDVERGCNILCATPGRLMDIIGREKIGLSKLKYLVLDEADRMLDMGFAPVMENLIGSP 431

  Fly   421 TM--RPEHQTLMFSATFPEEIQRMAGEFLK-NYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLI 482
            .|  :.|.||||||||:|.||||:|.:||| :::||.:|:||||||||:|||.|:.:|.||.||:
Frog   432 GMPAKEERQTLMFSATYPAEIQRLASKFLKSDHLFVVVGLVGGACSDVEQTILEIQEYRKRDKLV 496

  Fly   483 EILSEQADG---TIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLI 544
            |||  |:.|   |::||.||:.||.:|.:|.::.||||||||||.|.|||:|:|||::|...|::
Frog   497 EIL--QSSGNERTMIFVNTKKKADVIAGYLCQEHFPTTSIHGDREQCQREEAIRDFRSGKCPVIV 559

  Fly   545 ATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKIL 609
            .|:||:|||||:|::||||||:|.:||:||||||||||.||.|:|||||:..:|..:|..|||||
Frog   560 CTAVAARGLDIENVQHVINYDVPKEIDEYVHRIGRTGRCGNVGKATSFFNVNEDHVVARPLVKIL 624

  Fly   610 EGSGQTVPDFLRTCGAGGDGG----YSNQNFGGVDVRGRGNYVGDATNVEEEE-QWD 661
            ..:.|.||.:|.....||.|.    |:..:.||   .....||...::.:||| .||
Frog   625 TDAHQEVPAWLEEIAFGGHGALNSLYAADSMGG---EAGEKYVSAPSSAQEEEASWD 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	106/213 (50%)
		DEXDc	260..467	CDD:214692	113/213 (53%)
		Helicase_C	475..584	CDD:278689	67/111 (60%)
ddx4	XP_012818309.1	Cyano_gly_rpt	<113..162	CDD:275087	19/65 (29%)
		DEADc_DDX4	210..473	CDD:350810	129/263 (49%)
		SF2_C_DEAD	479..608	CDD:350174	78/130 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4660
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		oto103248
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060