DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and CG6418

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_648413.1	Gene:	CG6418 / 39218	FlyBaseID:	FBgn0036104	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	217/701 - (30%)
Similarity:	319/701 - (45%)	Gaps:	135/701 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IGGGRGGGAGG--YRGGNRDGGGFHGGRREGERDFRGGEGGFRGGQGG-SRGGQGGSRGGQG--- 119
            :.|.||.|.||  ||.....|...:........:.||..|. |||.|| ||||..||.....
  Fly     1 MSGYRGIGGGGFPYRKPASSGNNMNAVPPPPMLNARGYSGS-RGGFGGASRGGVTGSTTSTSKHG 64

  Fly   120 -----------------GFR----------------------------GGEGG--FRGRLYENED 137
                             |.|                            |..|.  ...:..|:.|
  Fly    65 YSTLDSISQYTNATNLVGKRKHHTDDDYFDDDDEPREKEIEQAYIPAPGSPGAPPTSAKKQEDSD 129

  Fly   138 GDER---------RGRLDREERGGER-------RGRLDREE-------------RGGERGERGDG 173
            .||.         ..::::|:|....       ||.:|.|:             ..|.|.|..|
  Fly   130 SDEDPLEQFMAGINQQVEKEKRQQAPKPPTQAVRGDIDDEDDEESYYRYMKENPNAGLRDEGSD- 193

  Fly   174 GFARRRRNEDDINNNNNIVEDVERKREFYIPP-EPSNDAIEIFSSGIASGIHFSKYNNIP----- 232
                   .|.:.:.:.|.:...::|....:|| ..|....|.|....     ::::::|.
  Fly   194 -------QEIEYDEDGNPIAPPKKKDIDPLPPIYHSEIEYEPFEKNF-----YTQHDDIAALDDE 246

  Fly   233 ----------VKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMA 287
                      |||||...|:|:..|......:.:|..|.|:.|..|||||..::|...||||::.
  Fly   247 QVRELRRTLGVKVTGPSPPKPVTSFGHFGFDEQLIKAVRKAEYTQPTPIQAQAVPTALSGRDIIG 311

  Fly   288 CAQTGSGKTAAFLLPILSKLLEDPHELELG-RPQVVIVSPTRELAIQIFNEARKFAFESYLKIGI 351
            .|:|||||||||:.|:|..:: |..:|:.| .|..:|::|||||::||:|||:||.....|.:..
  Fly   312 IAKTGSGKTAAFIWPMLMHVM-DQKQLKPGDGPIGLILAPTRELSLQIYNEAKKFGKVYNLNVVC 375

  Fly   352 VYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRI 416
            .|||.|...|::.:.:|..:::|||||::|.|...........|:||||||||..|||...:|.|
  Fly   376 CYGGGSKWEQSKALEQGAEIIVATPGRMIDMVKMKATNLRRVTFLVLDEADRMFHMGFEPQVRSI 440

  Fly   417 MTHVTMRPEHQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEV-NKYAKRS- 479
            ..||  ||:.|.|||||||.:.|:|:|.:.|.:.|.:..|.:..|..|:.|::|.. |...|.:
  Fly   441 CNHV--RPDRQCLMFSATFKKRIERLARDVLSDPVRIVQGDLNEANQDITQSVYVFPNPLQKWNW 503

  Fly   480 ---KLIEILSEQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMK 541
               .|::.|||  ...::||..|..|:.:::.|..||:....:|||..|:.|.:.:..||.....
  Fly   504 LLCHLVKFLSE--GSVLIFVTKKVDAETVSNNLLIKEYNCLLLHGDMDQADRNKVITQFKRKECD 566

  Fly   542 VLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLV 606
            :|:||.||:|||||.:|::|:|||....|:.:.||||||||.|..|.|.:.. .:||:..|..||
  Fly   567 ILVATDVAARGLDIPHIRNVVNYDTARDIETHTHRIGRTGRAGEKGNAYTLV-TDKDKEFAGHLV 630

  Fly   607 KILEGSGQTVPD-----------FLRTCGAGGDGGYSNQNFGGVDVRGRGN 646
            :.|||:.|.|||           |..:....|.|........|:..|.:||
  Fly   631 RNLEGADQLVPDDLMELAMKSSWFRSSRFKQGKGKRPTNTHTGLGYREKGN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	89/207 (43%)
		DEXDc	260..467	CDD:214692	90/207 (43%)
		Helicase_C	475..584	CDD:278689	43/112 (38%)
CG6418	NP_648413.1	DEADc	271..475	CDD:238167	89/206 (43%)
		DEXDc	284..489	CDD:214692	90/207 (43%)
		Helicase_C	504..609	CDD:278689	42/106 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9764
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840