DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and Ddx3y

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001102328.1	Gene:	Ddx3y / 364073	RGDID:	1309586	Length:	659	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	242/556 - (43%)
Similarity:	335/556 - (60%)	Gaps:	63/556 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SRGGQGGFRGGEGGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFAR- 177
            |.|.:...|.....|..|      |...|||.|       .|||.|.|..|...|..|.|.|.|
  Rat    69 SFGSRSDTRAKSSFFSDR------GSGSRGRFD-------DRGRSDYEGVGSRGGRSGFGKFERG 120

  Fly   178 ------RRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAI--EIFSSGIASGIHFSKYNNIPVK 234
                  .:.:|||                 :..|.|.::.:  |:||.| .:||:|.||::|||:
  Rat   121 GNSRWCDKADEDD-----------------WSKPLPPSERLEQELFSGG-NTGINFEKYDDIPVE 167

  Fly   235 VTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAF 299
            .||::.|..|:.|:..::.:||:.|:..:.|..|||:||.:||:|...|||||||||||||||||
  Rat   168 ATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAF 232

  Fly   300 LLPILSKLLED-PHEL--------ELGR----PQVVIVSPTRELAIQIFNEARKFAFESYLKIGI 351
            ||||||::..| |.|.        :.||    |..::::||||||:||:.|||||::.|.::..:
  Rat   233 LLPILSQIYTDGPGEALRAMKENGKYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCV 297

  Fly   352 VYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRI 416
            ||||.....|...:.||||:::||||||:|.::|..|..:..:::|||||||||||||...:|||
  Rat   298 VYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRI 362

  Fly   417 MTHVTMRPE--HQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRS 479
            :...||.|:  ..|:|||||||:|||.:|.:||..|:|:|:|.||....::.|.:..|.:..|||
  Rat   363 VEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEEADKRS 427

  Fly   480 KLIEILSEQADGT--IVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKV 542
            .|:::|:.....:  :||||||:|||.|..||..:.:..|||||||.|..||:||..|::|...:
  Rat   428 FLLDLLNATGKDSLILVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPI 492

  Fly   543 LIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVK 607
            |:||:||:|||||.|:|||||:|:||.|::|||||||||||||.|.|||||: |::..|..||:.
  Rat   493 LVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFN-ERNINITKDLLD 556

  Fly   608 ILEGSGQTVPDFLRTCG-----AGGDGGYSNQNFGG 638
            :|..:.|.||.:|....     .||..|.|...|.|
  Rat   557 LLVEAKQEVPSWLENMAFEHHYKGGSRGRSKSRFSG 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	109/221 (49%)
		DEXDc	260..467	CDD:214692	109/221 (49%)
		Helicase_C	475..584	CDD:278689	61/110 (55%)
Ddx3y	NP_001102328.1	eIF-4B	82..>170	CDD:283846	35/118 (30%)
		DEADc	180..402	CDD:238167	109/221 (49%)
		DEXDc	193..416	CDD:214692	109/222 (49%)
		Helicase_C	424..534	CDD:278689	61/109 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820