DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and Ddx50

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001013216.2	Gene:	Ddx50 / 361848	RGDID:	1310934	Length:	734	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	147/513 - (28%)
Similarity:	243/513 - (47%)	Gaps:	83/513 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LYENEDGDERRGRLDREERGGERRGRLDREERGGERGERG-----DGGFARRRRNEDDINNNNNI 191
            |.|:|...:.|.:.||.    :.|...:.||| .|..|.|     |....::.:..:.:|.:..
  Rat    17 LEESESQRKERQKNDRR----KSRHHSESEER-TETRENGVTDDLDAPKPKKAKTREKLNGDTK- 75

  Fly   192 VEDVERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIP-----------VKVTGSDVPQPIQ 245
             |.:....||    .||               |.|:..::|           .:|:.|:     .
  Rat    76 -EGLRFSDEF----SPS---------------HKSRRKDLPNGDVDEYEKRSKRVSSSE-----N 115

  Fly   246 HFTSADLRDIIIDNVNKSG----YKIPT---------------PIQKCSIPVISSGRDLMACAQT 291
            ...|:|..|..:....|.|    :.|..               |||..:...:..|:||:|.|:|
  Rat   116 SHKSSDKADETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQART 180

  Fly   292 GSGKTAAFLLPILSKLLEDPHELELGR-PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGG 355
            |:|||.:|.:|::.:|..:...::..| |:|::::||||||.|:..:.:....:  |.:...|||
  Rat   181 GTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRK--LNVACFYGG 243

  Fly   356 TSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHV 420
            ||::.|...|..|..:::.||||:.|.:....:.....|.|||||.|:|||:||:|.:..|: |.
  Rat   244 TSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDII-HE 307

  Fly   421 TMRPEH----QTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEV-------NK 474
            :.:.:.    |||:||||.|:.:.::|.:::|:. :..:.:||........|:..:       .:
  Rat   308 SYKSDSEDNPQTLLFSATCPQWVYKVAKKYMKSR-YEQVDLVGKMTQKAATTVEHLAIQCHWSQR 371

  Fly   475 YAKRSKLIEILSEQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGS 539
            .|....::::.|......|:|.|||:....:|.....|: ....:|||..|||||..|:.|:.||
  Rat   372 PAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQ-NAQCLHGDIAQSQREITLKGFREGS 435

  Fly   540 MKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEK 597
            .|||:||:||:|||||..:..||....|..::.|:||.|||||.|..|....|:.|.:
  Rat   436 FKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRE 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	71/230 (31%)
		DEXDc	260..467	CDD:214692	70/230 (30%)
		Helicase_C	475..584	CDD:278689	44/108 (41%)
Ddx50	NP_001013216.2	SrmB	130..608	CDD:223587	119/369 (32%)
		DEADc	136..339	CDD:238167	65/205 (32%)
		HELICc	369..486	CDD:238034	46/117 (39%)
		GUCT_RHII_Gualpha_beta	565..656	CDD:240593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920