DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and CG14443

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_572330.2	Gene:	CG14443 / 31595	FlyBaseID:	FBgn0029880	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	164/727 - (22%)
Similarity:	278/727 - (38%)	Gaps:	157/727 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GDWSDDEDTAKSFSGEAEGDGVGGS--GGEGGGYQGGNRDV---------------FGRIGGGRG 66
            |:|.|:|..|:....:....|...|  |.......|.:|.:               ...|..|..
  Fly    11 GNWKDNETDAEKVQKKPFLKGTKSSIWGSSASDISGQSRSLKSSSSVLSSKFVTKRLFTIQHGIE 75

  Fly    67 GGAGGYR------GGNRDGGGFHGGRREGERDFRG-GEGGFRG-----------GQGGSRGGQGG 113
            |....::      .|....|||....||.....|. |.|.|||           ...||......
  Fly    76 GQKPNFKIRSESFSGPHSAGGFSKSTRESRSKSRSMGNGKFRGKSHLRSSSESAHSSGSESSSSD 140

  Fly   114 SRGGQ---------GGFRGGEGGFRGRL-----------------------YENEDGDERRGRLD 146
            |..|.         ....|.:.|.|.|:                       .||::...|...|.
  Fly   141 SNSGSSSDSDSTTGSSSHGSDTGERPRMRSAVFRIHETWQSPNSFKAVKTSRENKESRSRSSSLP 205

  Fly   147 R-----------------EERGGERRGRLDREERGGER------GERG-----------DGGFAR 177
            :                 |.:....|||  ...|.|.|      ..|.           ...|.|
  Fly   206 QKRFCPSKTQNDLTYGSPEPKSPSNRGR--NSWRVGMRTPWKKSQSRSMSCSSIQKILVSRSFTR 268

  Fly   178 RRRNEDDINNNNNIVEDVERKREFYIPPEPSN------DAIEIFSSGIASGIHFSKYNNIPVKVT 236
            .|    ..:.|....:|..:.     |..|||      ...|:::    :..::.|.:||.:...
  Fly   269 SR----SPHRNTLCYQDQSKN-----PSRPSNYNTWKQPMDEVYN----NAANYRKRHNITLTSW 320

  Fly   237 G-SDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFL 300
            . .::|:|:..|..:.....|:..:...||..|||||..:..:...|::::..:..|:|||..:|
  Fly   321 NMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGKGTGKTLGYL 385

  Fly   301 LPILSKLLEDPHELELGR-PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNEC 364
            ||.:.|:......::..: |.|:|:...||.|:.:..|...:.....|:...:.|.:.::...|
  Fly   386 LPGIMKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYYTNPLELRTHCLLGNSQWQGHAE- 449

  Fly   365 ITRGCHVVIATPGRLLDFVD--RTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQ 427
                |.:::|:.||||..:|  :..:..|...::|||..|||:|:|...::.|::..  :||..|
  Fly   450 ----CDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRMIDVGLEGNICRLLCR--LRPHAQ 508

  Fly   428 TLMFSATFPEEIQRMAGEFLKNYVFVAIG---IVGGACSDVKQTIYEVNKYAKRSKLIEILSEQA 489
            .::.|.::...::|||.:||..|..:.:|   .:|....:::|.:..||..:|..:|::.|:...
  Fly   509 LIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGVRLQNIRQRVEVVNGLSKVERLMKELTAIY 573

  Fly   490 DGT------IVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSV 548
            |.:      :::|:.::..:.|.. |.....|...|||.|...:.:..:.||..|:..:::||.:
  Fly   574 DTSDIPGKVVIYVKRQKVVEELVD-LIRNCVPCEGIHGGRTAQENQGIIHDFGTGAYNIIVATQM 637

  Fly   549 ASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTG--RVGNNGRATSFFDPEKDRAIAADLVKILEG 611
            .|..||:..|::|||||.|..||.||.|:.|||  ....|....|||.....:.:.
  Fly   638 TSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCLSYNRNCEVISFFTMANYKLVT--------- 693

  Fly   612 SGQTVPDFLRTC 623
               .|.|||:.|
  Fly   694 ---EVVDFLKIC 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	55/209 (26%)
		DEXDc	260..467	CDD:214692	55/212 (26%)
		Helicase_C	475..584	CDD:278689	35/116 (30%)
CG14443	NP_572330.2	P-loop_NTPase	332..535	CDD:304359	55/209 (26%)
		DEXDc	345..544	CDD:214692	54/205 (26%)
		Helicase_C	560..670	CDD:278689	33/110 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451605
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940