DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and Ddx4

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_038958110.1	Gene:	Ddx4 / 310090	RGDID:	1308793	Length:	733	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	315/748 - (42%)
Similarity:	426/748 - (56%)	Gaps:	107/748 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDWDDE----------PIVD----TRGARGGDWSDDEDTAKSFSGEAEGDGVGG-----SGGEGG 48
            :||:.|          |:.:    :.||.|    |..:...:.|.|.| ||..|     ..|...
  Rat     4 EDWEAEILKPHVSSYVPVFEKDKYSSGANG----DTFNRTSASSSEME-DGPSGRDHFMRSGFSS 63

  Fly    49 GYQGGNRDV-----------FGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERD-------FRG 95
            |...||||:           .|..|.|:|.|..|:.....:.|...|..:|...|       .||
  Rat    64 GRNLGNRDIGESSKRETTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESTNDCEDTQTRSRG 128

  Fly    96 --GEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGF-RGR---LYENEDGDERRGRLDREERGGER 154
              ..||:..|......|. ..|||:|.|||..||| .||   .|:.:.|.:|.|.|     .|.|
  Rat   129 FSKRGGYPDGNDSEASGP-FRRGGRGSFRGCRGGFGLGRPNSEYDQDQGSQRGGGL-----FGSR 187

  Fly   155 R-----------GRLDR-EERGGERGERGDGGFARRRRNEDDI-----NNNNNIVE-----DVER 197
            :           |..|. :.|.|    .|.||:  :..||:.:     |:..:..|     |::.
  Rat   188 KPAASDSVQCFTGSGDTFQSRSG----NGRGGY--KGLNEEVVTGSGKNSWKSEAEGGESSDIQG 246

  Fly   198 KREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNK 262
            .:..||||.|..|...||:. ..:||:|.||:.|.|:|:|.|.|..|..|..|:|...:.:|:.|
  Rat   247 PKVTYIPPPPPEDEDSIFAH-YQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAK 310

  Fly   263 SGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLED----PHELELGRPQVVI 323
            :||...||:||.|||::.:|||||||||||||||||||||||:.::.|    ....||..|:.:|
  Rat   311 AGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECII 375

  Fly   324 VSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFI 388
            |:|||||..||:.|||||:|.:.::..::||||.|.|....|.:||:::.||||||:|.:.:..|
  Rat   376 VAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSIRQIVQGCNILCATPGRLMDIIGKEKI 440

  Fly   389 TFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTM--RPEHQTLMFSATFPEEIQRMAGEFLK-NY 450
            ..:..:::|||||||||||||..:|:::::...|  :.:.|||:|||||||||||:|||||| ||
  Rat   441 GLKQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGEFLKSNY 505

  Fly   451 VFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQAD-GTIVFVETKRGADFLASFLSEKEF 514
            :|||:|.|||||.||:|:|.:|.:|:||.||:|||....| .|:||||||:.|||:|:||.:::.
  Rat   506 LFVAVGQVGGACRDVQQSILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKI 570

  Fly   515 PTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGR 579
            .||||||||.|.:|||||.||:.|...||:|||||:|||||:|::||||:|:||.||:|||||||
  Rat   571 STTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGR 635

  Fly   580 TGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFLR--TCGAGGDGGYSNQNFGGV--D 640
            |||.||.|||.||||.|.|..:|..|||:|..:.|.||.:|.  ...:.....:||...|.|  .
  Rat   636 TGRCGNTGRAISFFDTESDNHLAQPLVKVLSDAQQDVPAWLEEIAFSSYAPPSFSNSTRGAVFAS 700

  Fly   641 VRGRGNYVG------------DATNVEEEEQWD 661
            |..|.|:.|            .|.|..::|.||
  Rat   701 VDTRKNFQGKNTLNTAGISSAQAPNPVDDESWD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	111/213 (52%)
		DEXDc	260..467	CDD:214692	117/213 (55%)
		Helicase_C	475..584	CDD:278689	71/109 (65%)
Ddx4	XP_038958110.1	DEADc_DDX4	262..514	CDD:350810	128/252 (51%)
Ddx4	XP_038958110.1	SF2_C_DEAD	520..649	CDD:350174	81/128 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341473
Domainoid	1	1.000	135	1.000	Domainoid score	I4852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1481
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		oto96543
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5926
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890