DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and dbp2

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_596523.1	Gene:	dbp2 / 2541383	PomBaseID:	SPBP8B7.16c	Length:	550	Species:	Schizosaccharomyces pombe

Alignment Length:	572	Identity:	206/572 - (36%)
Similarity:	307/572 - (53%)	Gaps:	56/572 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 FRGGE--GGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDG---GFARR-- 178
            :|..|  |.:.|:    |||...|||.     ||   |..:...|||.||...||   |:.:|
pombe     3 YRDNEYSGNYNGK----EDGYNSRGRY-----GG---GYRNNYSRGGGRGGFNDGASYGYDQRGQ 55

  Fly   179 RRN--EDDINNNNNIVED------VERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKV 235
            .||  |.|....|.:.:|      :..:::||...|      .:.:...|....:.|...|.|.
pombe    56 GRNFYESDGPGANLVKKDWKNETLIPFQKDFYKEHE------NVRNRSDAEVTEYRKEKEIVVH- 113

  Fly   236 TGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFL 300
             |.:||:|:..|..|...:.::..|.:.|::.|||||:.:.|:..||||::..:.||||||.::.
pombe   114 -GLNVPKPVTTFEEAGFPNYVLKEVKQLGFEAPTPIQQQAWPMAMSGRDMVGISATGSGKTLSYC 177

  Fly   301 LPILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECI 365
            ||.:..:...|.......|.|::::||||||:||..|..||...|.::...||||.....|...:
pombe   178 LPAIVHINAQPLLSPGDGPIVLVLAPTRELAVQIQQECTKFGKSSRIRNTCVYGGVPRGPQIRDL 242

  Fly   366 TRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQTLM 430
            .||..:.|||||||||.:|..........::|||||||||||||...:|:|:..:  ||:.||:|
pombe   243 IRGVEICIATPGRLLDMLDSNKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQI--RPDRQTVM 305

  Fly   431 FSATFPEEIQRMAGEFLKNYVFVAIGIVGGACS-DVKQTIYEVNKYAKRSKL----IEILSEQAD 490
            ||||:|:|:||:|.::|.:|:.|.:|.:..|.| ::||.:..|:...||::|    .|:|.::.:
pombe   306 FSATWPKEVQRLARDYLNDYIQVTVGSLDLAASHNIKQIVEVVDNADKRARLGKDIEEVLKDRDN 370

  Fly   491 GTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDI 555
            ..::|..|||.||.:..||.:..:|..:||||:.|.:|:..|.:|:.|...:::||.|||||:|:
pombe   371 KVLIFTGTKRVADDITRFLRQDGWPALAIHGDKAQDERDWVLNEFRTGKSPIMVATDVASRGIDV 435

  Fly   556 KNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFL 620
            |.|.||.|||.|...:|||||||||||.|..|.|.::|..:..:. |.:||.||..:.|.:...|
pombe   436 KGITHVFNYDFPGNTEDYVHRIGRTGRAGAKGTAYTYFTSDNAKQ-ARELVSILSEAKQDIDPKL 499

  Fly   621 R------TCGAGGD---GGYSNQNF---GGVDVRGRGNYVGDATNVEEEEQW 660
            .      :.|.||:   |||....|   ||...|.|| :.|..:......:|
pombe   500 EEMARYSSGGRGGNYRRGGYGRGGFRRGGGYGNRNRG-FTGSNSAPLARSRW 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	85/206 (41%)
		DEXDc	260..467	CDD:214692	87/207 (42%)
		Helicase_C	475..584	CDD:278689	50/112 (45%)
dbp2	NP_596523.1	PTZ00110	2..507	CDD:240273	192/526 (37%)
		DEADc	124..329	CDD:238167	85/206 (41%)
		HELICc	340..472	CDD:238034	56/131 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920