DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and glh-1

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_491963.1	Gene:	glh-1 / 172414	WormBaseID:	WBGene00001598	Length:	763	Species:	Caenorhabditis elegans

Alignment Length:	779	Identity:	287/779 - (36%)
Similarity:	388/779 - (49%)	Gaps:	159/779 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQGGNRDVFGRIGGGRGGGAGGYRGGNRDGGGFHGG 85
            |||.|..||:.:|...|.|.||....|.|:.||.....| .|||..||: |:.|||..|.||.||
Worm     5 WSDSESAAKAKTGFGSGGGFGGGNNGGSGFGGGKNGGTG-FGGGNTGGS-GFGGGNTGGSGFGGG 67

  Fly    86 RREGERDFRGGE---GGFRGGQ------GGSRGGQGGSR--------------GGQGGFRG---- 123
            :..|. .|.||.   .||.||.      ||:..|.|||.              ||.|||.|
Worm    68 KTGGS-GFGGGNTCGSGFGGGSTGGSPYGGASSGFGGSTATSGFGSGEKSSAFGGSGGFGGSATG 131

  Fly   124 ---------------GEGGFRGRLYEN----------------EDGDERRGRL------------ 145
                           ||||..|....|                |...||..|:
Worm   132 FGSGGGSFGGGNSGFGEGGHGGGERNNNCFNCQQPGHRSSDCPEPRKEREPRVCYNCQQPGHTSR 196

  Fly   146 -------DREERGGERRGRLDREERGGERGERGDGGFA--------------------------- 176
                   .||.|.|...|.......||..|..|||||.
Worm   197 ECTEERKPREGRTGGFGGGAGFGNNGGNDGFGGDGGFGGGEERGPMKCFNCKGEGHRSAECPEPP 261

  Fly   177 RRRRNEDDINNNNNIVEDVERKRE---------FYIPPEPSNDAIEIFS-SGIASGIHFSKYNNI 231
            |...|..:..:.:|...:..:.||         .|:|.|.:.:  ::|: ..|:.|:.|:|:.:.
Worm   262 RGCFNCGEQGHRSNECPNPAKPREGVEGEGPKATYVPVEDNME--DVFNMQKISEGLMFNKFFDA 324

  Fly   232 PVKVTGSDVP---QPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGS 293
            .||:|.|:..   :|.:.|..|:|.:.:..||..:||...||||:.::|::..|.|:||||||||
Worm   325 EVKLTSSEKTVGIKPCKTFAEANLTETMQKNVAHAGYSKTTPIQQYALPLVHQGYDIMACAQTGS 389

  Fly   294 GKTAAFLLPILSKLLEDPHELELGR----PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYG 354
            ||||||||||:::|::|.:....|.    |:.:|::||||||.||:||.||||:::.::|..|||
Worm   390 GKTAAFLLPIMTRLIDDNNLNTAGEGGCYPRCIILTPTRELADQIYNEGRKFAYQTMMEIKPVYG 454

  Fly   355 GTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLD-MGFSEDMRRIMT 418
            |.:..:....|.:|..:::.|.||:..|.:...|..:..||.||||||||:| |||..|:..|:.
Worm   455 GLAVGYNKGQIEKGATIIVGTVGRIKHFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIETIVN 519

  Fly   419 HVTM--RPEHQTLMFSATFPEEIQRMAGEFLK-NYVFVAIGIVGGACSDVKQTIYEVNKYAKRSK 480
            :.:|  :...||||||||||:.:|..|..||: |||.:||..:|.|...|.|......:..|:.|
Worm   520 YDSMPRKENRQTLMFSATFPDSVQEAARAFLRENYVMIAIDKIGAANKCVLQEFERCERSEKKDK 584

  Fly   481 LIEILSEQADG-------------TIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQAL 532
            |:|:|....|.             |:|||..:..||.|||.||..:.|..:|||.|.|.:|.:||
Worm   585 LLELLGIDIDSYTTEKSAEVYTKKTMVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEAL 649

  Fly   533 RDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEK 597
            |.|:|||..|||||:||.||||||.:.||||||||..||||:|||||||||||:||||||.  .:
Worm   650 RQFRNGSKPVLIATAVAERGLDIKGVDHVINYDMPDNIDDYIHRIGRTGRVGNSGRATSFI--SE 712

  Fly   598 DRAIAADLVKILEGSGQTVPDFLRTCGAGGDGGYSNQNFGGVDVRGRGNYVGDATNV-EEEEQW 660
            |.::.::||.:|..:.|.|||:::  ||.| |.|....||.          ...|.| ::||.|
Worm   713 DCSLLSELVGVLADAQQIVPDWMQ--GAAG-GNYGASGFGS----------SVPTQVPQDEEGW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	97/214 (45%)
		DEXDc	260..467	CDD:214692	98/214 (46%)
		Helicase_C	475..584	CDD:278689	64/121 (53%)
glh-1	NP_491963.1	zf-CCHC	158..175	CDD:278525	1/16 (6%)
		zf-CCHC	183..200	CDD:278525	1/16 (6%)
		ZnF_C2HC	243..259	CDD:197667	0/15 (0%)
		zf-CCHC	262..279	CDD:278525	3/16 (19%)
		DEADc	343..558	CDD:238167	97/214 (45%)
		DEXDc	359..561	CDD:214692	94/201 (47%)
		Helicase_C	579..701	CDD:278689	64/121 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850