DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and glh-2

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_491876.1	Gene:	glh-2 / 172361	WormBaseID:	WBGene00001599	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	813	Identity:	278/813 - (34%)
Similarity:	376/813 - (46%)	Gaps:	202/813 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SGEAEGDGVGGSGGEGGGYQGGNRDVFGR---------------IGGGRGGGAGGYRGGNRDGGG 81
            ||:|.|.|.||:...|.|:..|..:.||.               .|||..||:|...|||.:|.|
Worm   180 SGKAGGTGFGGNSNSGSGFGSGLTNGFGSGNNHESGFGGGKSGGFGGGNSGGSGFGSGGNSNGFG 244

  Fly    82 FHGG------------------------------------------------------RREGERD 92
            ..||                                                      .|||...
Worm   245 SGGGGQDRGERNNNCFNCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNG 309

  Fly    93 FRGGEGGFRGGQGGSRG-----------GQGGSRG-GQGGFRGGEGGF--------RGRLYEN-- 135
            |.||..||.||.||..|           |..|..| |.|||.|...||        ||....|
Worm   310 FTGGSSGFGGGNGGGTGFDSGLTNGFGSGNNGESGFGSGGFGGNSNGFGSGGGGQDRGERNNNCF 374

  Fly   136 -------EDGDERRGRLDREER---GGERRGRLDR---EERGGERGERG---------DGGFARR 178
                   ...|....:.:||.|   ..::.|...|   |||....|..|         ||||.
Worm   375 NCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTSGFGGGNDGGFG-- 437

  Fly   179 RRNEDDINNNN----------------------------NIVEDVERKRE--------------- 200
            ..|.:...||.                            |..|...|..|
Worm   438 GGNAEGFGNNEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGAEGEG 502

  Fly   201 ---FYIPPEPSNDAIEIFS-SGIASGIHFSKYNNIPVKVTGSDVP---QPIQHFTSADLRDIIID 258
               .|:|.|.:.:  |:|: ..|:.|:.|:|:.:..||:|....|   :..:.|:.|:|.:.:..
Worm   503 PKATYVPVEDNME--EVFNMQKISEGLMFNKFFDAEVKITSDKKPVGVKTCKTFSEANLGETMKK 565

  Fly   259 NVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPHELELGR----P 319
            ||..:||...||||:.::|:|..|.|:||||||||||||||||||:::|:::......|.    |
Worm   566 NVAHAGYTKTTPIQQYTLPLIHQGHDIMACAQTGSGKTAAFLLPIMARLIDENDLNTAGEGGCYP 630

  Fly   320 QVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIATPGRLLDFVD 384
            :.:|::|||||..||:||.||||:::.::|..||||.:..:....|.:|..:::.|.||:..|.:
Worm   631 RCIILTPTRELTDQIYNEGRKFAYQTMMEIRPVYGGLAVGYNKGQIEKGATIIVGTVGRIKHFCE 695

  Fly   385 RTFITFEDTRFVVLDEADRMLD-MGFSEDMRRIMTHVTM--RPEHQTLMFSATFPEEIQRMAGEF 446
            ...|..:..||.||||||||:| |||..|:..|:.:.:|  :...||||||||||:.:|..|...
Worm   696 EGTIKLDKCRFFVLDEADRMIDAMGFGTDIDTIVNYESMPKKENRQTLMFSATFPDSVQEAARNH 760

  Fly   447 LK-NYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQADG-------------TIVFVE 497
            || .|:.:||..:|.|...|.|...:.::..|:.||:|||....|.             |||||.
Worm   761 LKEGYIMLAIDKIGAANKCVLQEFEKCDRSEKKDKLLEILGIDIDSYTTEKNSEVYTKKTIVFVS 825

  Fly   498 TKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVI 562
            .:..||.|||.||..:.|..:|||.|.|.:|.:|||.|:|||..|||||:||.||||||.:.|||
Worm   826 QRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIKGVDHVI 890

  Fly   563 NYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFLRTCGAGG 627
            |||||..||||:|||||||||||.||||||.  .:|..:.::||::|..:.|.||::::    |.
Worm   891 NYDMPDNIDDYIHRIGRTGRVGNAGRATSFI--SEDCNLLSELVRVLSDADQLVPEWMQ----GA 949

  Fly   628 DGGYSNQNFGGVDVRGRGNYVGDATNVEEEEQW 660
            .||    |||.    ..|......|..::|:.|
Worm   950 SGG----NFGA----SFGFESSVPTQKQDEDCW 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	94/214 (44%)
		DEXDc	260..467	CDD:214692	95/214 (44%)
		Helicase_C	475..584	CDD:278689	66/121 (55%)
glh-2	NP_491876.1	Keratin_2_tail	69..177	CDD:292827
		zf-CCHC	257..274	CDD:278525	0/16 (0%)
		zf-CCHC	282..299	CDD:278525	0/16 (0%)
		zf-CCHC	371..388	CDD:278525	2/16 (13%)
		PTZ00368	373..508	CDD:173561	22/136 (16%)
		zf-CCHC	396..413	CDD:278525	3/16 (19%)
		PRK01297	459..924	CDD:234938	192/468 (41%)
		zf-CCHC	473..490	CDD:278525	4/16 (25%)
		DEADc	554..763	CDD:238167	92/208 (44%)
		Helicase_C	790..912	CDD:278689	66/121 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840