DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and glh-4

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_491207.3	Gene:	glh-4 / 171941	WormBaseID:	WBGene00001601	Length:	1156	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	236/767 - (30%)
Similarity:	335/767 - (43%)	Gaps:	159/767 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GARGGDWSDDEDTAKSFSGEAEGDGVGGSGGEGG-GYQGGNRDVFGRIGGGRGGGA-GGYRG--- 74
            |.:.|.......||::.....|..|.||.....| |....|...||:...|.||.. .|:.|
Worm   428 GLKAGFGGHRASTAENSGLPTETTGFGGKLPPAGFGASSSNESAFGQQSKGFGGATKNGFGGDSS 492

  Fly    75 ---GNRDGGGFHGGRREGERD----FRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGFRGRL 132
               |.|| .||.|.:.:|..|    .:.|.|.|..|     ||...|..|..|| |....|....
Worm   493 NSFGKRD-SGFGGPQDQGFGDTDAPSKSGLGSFNTG-----GGAVKSAFGAAGF-GSSSNFGNGN 550

  Fly   133 YENEDGDERRGRLDREERGGER---------RGRLDRE--------------ERGGE-------- 166
            ...|..|.:||..|    ||||         .|.:.:|              |:.|.
Worm   551 TFGEPSDNQRGNWD----GGERPRGCHNCGEEGHISKECDKPKVPRFPCRNCEQLGHFASDCDQP 611

  Fly   167 RGERG-------DGGFA----------RRRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAIEI 214
            |..||       :|.||          ...||   .....:..:|.:.:|....|.||.....|.
Worm   612 RVPRGPCRNCGIEGHFAVDCDQPKVPRGPCRN---CGQEGHFAKDCQNERVRMEPTEPCRRCAEE 673

  Fly   215 FSSGI--------ASGIHFSKY---------------NN-----IPVKVTGSDVPQPIQHFTSAD 251
            ...|.        ..|.....|               ||     ...||..|.....|....|.|
Worm   674 GHWGYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKIDFDQKVVASTGKVEIPDMASFD 738

  Fly   252 ----LRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPH 312
                |...:.||:.:.....|||||:.|...|..|.|::|||.||||||.|||:|.:.||:|
Worm   739 GFKILPQDLHDNLKRMKMNRPTPIQRASFFPIMHGNDVVACAHTGSGKTLAFLIPFVIKLME--- 800

  Fly   313 ELELGR--------PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRG- 368
            |.|..|        |:::||:|||||..|.|..||:..:|:.||.|:.:||.| |:.|....|.
Worm   801 EFEKDRDVTDEKPSPRLLIVAPTRELVNQTFTTARQLTYETGLKCGLAFGGYS-RNANVQHLRSF 864

  Fly   369 --CHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMG-FSEDMRRIMTHVTMRPEHQTLM 430
              .::::||.|||.|||:...::....:::||||||||:|.. |.|::.:|:.....|.: ||::
Worm   865 SQLNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRMVDSNDFGEEVSKIIGSPGERTQ-QTVL 928

  Fly   431 FSATFPEEIQR-MAGEFLK-NYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILS------- 486
            |||:|.|::|. ...:|:| .|..:.:...|.|...:.|.|..|.:..||..:.::|.
Worm   929 FSASFSEDLQSDDLPKFVKEGYTMLQVDKFGTANEKIDQKILPVPRTEKRDAIYKLLGIDENTVT 993

  Fly   487 ------EQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIA 545
                  .:...|::||.:.:..|.||:.:|.....|.|:|..:.|.||::.|.||:.|..:.::|
Worm   994 LLPDAPIEKQKTLIFVNSVKFCDTLAALISSAGVSTISMHSYQNQEQRDRTLDDFRRGKYQCMVA 1058

  Fly   546 TSVASRGLDIKNIKHVINYDMPSK--IDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKI 608
            ::|.:|||:|..:.||:|||||.|  .|:||:|||||||.|..|.:|:|.|.|.|..|...||.|
Worm  1059 SNVCARGLNIAGLDHVVNYDMPDKNGFDEYVNRIGRTGRAGFTGTSTAFVDVENDTDIIPCLVSI 1123

  Fly   609 LEGSGQTVPDFLRTCGAGGDGGYSNQNFGGVDVRGRGNYVGDATNVEEEEQW 660
            |..:.:.||::| |.|||      :|..||.|..            |:|::|
Worm  1124 LNEAKKEVPEWL-TEGAG------HQEEGGDDWN------------EQEQEW 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	87/224 (39%)
		DEXDc	260..467	CDD:214692	84/220 (38%)
		Helicase_C	475..584	CDD:278689	44/123 (36%)
glh-4	NP_491207.3	zf-CCHC	570..587	CDD:278525	2/16 (13%)
		PTZ00368	572..685	CDD:173561	19/115 (17%)
		zf-CCHC	616..633	CDD:278525	4/16 (25%)
		zf-CCHC	639..656	CDD:278525	3/19 (16%)
		P-loop_NTPase	743..938	CDD:304359	81/199 (41%)
		DEXDc	751..968	CDD:214692	84/221 (38%)
		HELICc	964..1104	CDD:238034	49/139 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910