DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and DDX3X

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001347.3	Gene:	DDX3X / 1654	HGNCID:	2745	Length:	662	Species:	Homo sapiens

Alignment Length:	683	Identity:	266/683 - (38%)
Similarity:	374/683 - (54%)	Gaps:	136/683 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RGGGAGGYRG-------GNRDG-GGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGF 121
            :.||:...:|       .||:. .||:      ::|..|...........|.|.:..|||....|
Human    27 QSGGSTASKGRYIPPHLRNREATKGFY------DKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFF 85

  Fly   122 RGGEGGFRGRLYENEDGDERRGRLDREERG--GERRGRLDREERGGERG--ERGDGGFARRRRNE 182
            .....|.|||.       :.|||.|.:..|  |:|.| ..:.||||...  ::.|         |
Human    86 SDRGSGSRGRF-------DDRGRSDYDGIGSRGDRSG-FGKFERGGNSRWCDKSD---------E 133

  Fly   183 DDINNNNNIVEDVERKREFYIPPEPSNDAI--EIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQ 245
            ||                 :..|.|.::.:  |:||.| .:||:|.||::|||:.||::.|..|:
Human   134 DD-----------------WSKPLPPSERLEQELFSGG-NTGINFEKYDDIPVEATGNNCPPHIE 180

  Fly   246 HFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLED 310
            .|:..::.:||:.|:..:.|..|||:||.:||:|...|||||||||||||||||||||||::..|
Human   181 SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSD 245

  Fly   311 -PHEL-----ELGR-------PQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQN 362
             |.|.     |.||       |..::::||||||:||:.|||||::.|.::..:||||.....|.
Human   246 GPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQI 310

  Fly   363 ECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPE-- 425
            ..:.||||:::||||||:|.::|..|..:..:::|||||||||||||...:|||:...||.|:
Human   311 RDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGV 375

  Fly   426 HQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQAD 490
            ..|:|||||||:|||.:|.:||..|:|:|:|.||....::.|.:..|.:..|||.|:::|:  |.
Human   376 RHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLN--AT 438

  Fly   491 G----TIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASR 551
            |    |:||||||:|||.|..||..:.:..|||||||.|..||:||..|::|...:|:||:||:|
Human   439 GKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAAR 503

  Fly   552 GLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTV 616
            ||||.|:|||||:|:||.|::|||||||||||||.|.|||||: |::..|..||:.:|..:.|.|
Human   504 GLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFN-ERNINITKDLLDLLVEAKQEV 567

  Fly   617 P--------------------------------DFLRTCGA---------------GGDGGYSNQ 634
            |                                |:.::.||               ||.|..|::
Human   568 PSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSR 632

  Fly   635 NFGGVDVRG-------RGNYVGDATNVEEEEQW 660
            .|||....|       .|||     |.:..:.|
Human   633 GFGGGGYGGFYNSDGYGGNY-----NSQGVDWW 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	110/221 (50%)
		DEXDc	260..467	CDD:214692	110/221 (50%)
		Helicase_C	475..584	CDD:278689	64/112 (57%)
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269\|PubMed:18636090	2..139		35/151 (23%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:30131165, ECO:0000269\|PubMed:31575075	12..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..144		37/156 (24%)
		Interaction with EIF4E. /evidence=ECO:0000269\|PubMed:17667941	38..44		0/5 (0%)
		PTZ00110	57..580	CDD:240273	242/560 (43%)
		Interaction with VACV protein K7. /evidence=ECO:0000269\|PubMed:19913487	81..90		1/8 (13%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269\|PubMed:30256975	88..123		14/42 (33%)
		Interaction with GSK3B. /evidence=ECO:0000269\|PubMed:18846110	100..662		246/597 (41%)
		Interaction with IKBKE	100..110		4/9 (44%)
		Interaction with CHUK. /evidence=ECO:0000269\|PubMed:17667941	139..172		14/33 (42%)
		DEADc_DDX3	160..410	CDD:350809	123/249 (49%)
		Q motif	180..208		8/27 (30%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		1/8 (13%)
		DEAD box	347..350		2/2 (100%)
		Interaction with HCV core protein. /evidence=ECO:0000269\|PubMed:10329544	409..662		100/260 (38%)
		Interaction with NXF1. /evidence=ECO:0000269\|PubMed:18596238	536..661		32/131 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..634		7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820