DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vas and Ddx4

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_011242920.1	Gene:	Ddx4 / 13206	MGIID:	102670	Length:	738	Species:	Mus musculus

Alignment Length:	747	Identity:	308/747 - (41%)
Similarity:	426/747 - (57%)	Gaps:	100/747 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDWDDE----------PIVD----TRGARGGDWSDDEDTAKSFSGEAEGDGVGG-----SGGEGG 48
            :||:.|          |:.:    :.||.|..::....::..|:.|.| ||..|     ..|...
Mouse     4 EDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSVLFALEME-DGPSGRDDFMRSGFPS 67

  Fly    49 GYQGGNRDV-----------FGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERDFRGGEGGFRG 102
            |...|:||:           .|..|.|:|.|..|:.....:.|...|..:|...|....:...||
Mouse    68 GRSLGSRDIGESSKKENTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESNNDCEDNQTRSRG 132

  Fly   103 --GQGGSRGGQGGS------RGGQGGFRGGEGGF-RGRLYENEDGDERRGRLDREERGGERRGRL 158
              .:||.:.|....      |||:|.|||..||| .||  .|.:.|:.:|    .:|||...|
Mouse   133 FSKRGGCQDGNDSEASGPFRRGGRGSFRGCRGGFGLGR--PNSESDQDQG----TQRGGGLFG-- 189

  Fly   159 DREERGGE--------------RGERGDGGFARRRRNEDDI-----NNNNNIVE-----DVERKR 199
            .|:....:              |...|.||:  :..||:.:     |:..:..|     |.:..:
Mouse   190 SRKPAASDSVQCLTGNGDTYQSRSGSGRGGY--KGLNEEVVTGSGKNSWKSETEGGESSDSQGPK 252

  Fly   200 EFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNKSG 264
            ..||||.|..|...||:. ..:||:|.||:.|.|:|:|.|.|..|..|..|:|...:.:|:.|:|
Mouse   253 VTYIPPPPPEDEDSIFAH-YQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAG 316

  Fly   265 YKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLED----PHELELGRPQVVIVS 325
            |...||:||.|||::.:|||||||||||||||||||||||:.::.|    ....||..|:.:||:
Mouse   317 YTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVA 381

  Fly   326 PTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITF 390
            |||||..||:.|||||:|.:.::..::||||.|.|....|.:||:::.||||||:|.:.:..|..
Mouse   382 PTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGL 446

  Fly   391 EDTRFVVLDEADRMLDMGFSEDMRRIMTHVTM--RPEHQTLMFSATFPEEIQRMAGEFLK-NYVF 452
            :..:::|||||||||||||..:|:::::...|  :.:.|||:|||||||||||:||:||| :|:|
Mouse   447 KQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLF 511

  Fly   453 VAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQAD-GTIVFVETKRGADFLASFLSEKEFPT 516
            ||:|.|||||.||:|||.:|.:|:||.||:|||....| .|:||||||:.|||:|:||.:::..|
Mouse   512 VAVGQVGGACRDVQQTILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKIST 576

  Fly   517 TSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTG 581
            |||||||.|.:|||||.||:.|...||:|||||:|||||:|::||||:|:||.||:|||||||||
Mouse   577 TSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTG 641

  Fly   582 RVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFLRTCGAGG--DGGYSNQNFGG---VDV 641
            |.||.|||.||||.:.|..:|..|||:|..:.|.||.:|.......  ...:|:...||   ..|
Mouse   642 RCGNTGRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIAFSTYVPPSFSSSTRGGAVFASV 706

  Fly   642 RGRGNYVG------------DATNVEEEEQWD 661
            ..|.||.|            .|.|..::|.||
Mouse   707 DTRKNYQGKHTLNTAGISSSQAPNPVDDESWD 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	109/213 (51%)
		DEXDc	260..467	CDD:214692	115/213 (54%)
		Helicase_C	475..584	CDD:278689	71/109 (65%)
Ddx4	XP_011242920.1	DEADc_DDX4	266..518	CDD:350810	126/252 (50%)
Ddx4	XP_011242920.1	SF2_C_DEAD	524..653	CDD:350174	82/128 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837732
Domainoid	1	1.000	143	1.000	Domainoid score	I4655
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	481	1.000	Inparanoid score	I1444
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	1	1.000	-	-		oto92988
orthoMCL	1	0.900	-	-		OOG6_100461
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4819
SonicParanoid	1	1.000	-	-		X5926
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920