DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and AgaP_AGAP008601

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_314700.4	Gene:	AgaP_AGAP008601 / 1275453	VectorBaseID:	AGAP008601	Length:	611	Species:	Anopheles gambiae

Alignment Length:	501	Identity:	141/501 - (28%)
Similarity:	248/501 - (49%)	Gaps:	89/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LYENEDGDERRGRLDREERGGERRGRLDREE---------RGGERGERGDGGFARRRRNEDDINN 187
            |.||.:.:|   ...:.::..:::.::.::|         ||.:|.:.........::|.|:.::
Mosquito    27 LEENYEAEE---ATPKSKQKLKKKNKIPQQEEDEQDVAVGRGVKRPKDDSDDEDEEQQNGDEADS 88

  Fly   188 NNNIVEDVERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADL 252
            |.   |..|.::|..: |..:|.|.||....       .::.::..||:
Mosquito    89 NG---EGKEAEQEETV-PSMTNSAYEIILGN-------REFKSLEGKVS---------------- 126

  Fly   253 RDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPHELELG 317
             |..:..:.:.|:...|.||..|||.:..||||:..|:||||||.|||:|.:..:    |:|..
Mosquito   127 -DHTMKAIGEMGFTKMTEIQAKSIPPLLEGRDLIGSAKTGSGKTLAFLIPAVELI----HKLRF- 185

  Fly   318 RPQ----VVIVSPTRELAIQIF---NEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIAT 375
            :|:    |:::|||||||:|||   .|...:..::|   |::.||.|...:||.:.:|.::::||
Mosquito   186 KPRNGAGVIVISPTRELAMQIFGVLKELMTYHCQTY---GLLMGGASRHTENEKLEKGINIIVAT 247

  Fly   376 PGRLLDFVDRT--FITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQTLMFSATFPEE 438
            ||||||.:..|  |: |::.:.:::||.||:|::||.||:::|::  .:..:.||::||||....
Mosquito   248 PGRLLDHLKSTPNFL-FKNLQCLIIDECDRILEIGFEEDLKQIIS--ILPKKRQTMLFSATQSSR 309

  Fly   439 IQRMAGEFLKN---YVFV--------AIGIVGG--ACSDVKQ--TIYEVNKYAKRSKLIEILSEQ 488
            ::.:....||:   ||.|        ..|:..|  .|...::  .::...|..::.|:
Mosquito   310 LEELGKLALKSEPIYVGVDDNKKEATVTGLEQGYIVCPSERRLLVLFTFLKKNRKKKV------- 367

  Fly   489 ADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGL 553
                :||..:.....|.....:..:.|..||||.:.||:|......|.|....:|:.|.||:|||
Mosquito   368 ----MVFFSSCLSVKFHHELFNYIDLPVMSIHGKQKQSKRTSVFFQFCNAETGILLCTDVAARGL 428

  Fly   554 DIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNN--GRATSFFDPEK 597
            ||..:..::.||.|:...:|:||:|||.| |.:  |.|.....||:
Mosquito   429 DIPAVDWIVQYDPPNDTKEYIHRVGRTAR-GEDLCGHALLMLRPEE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	78/226 (35%)
		DEXDc	260..467	CDD:214692	80/228 (35%)
		Helicase_C	475..584	CDD:278689	33/108 (31%)
AgaP_AGAP008601	XP_314700.4	SrmB	117..596	CDD:223587	122/397 (31%)
		DEADc	118..325	CDD:238167	77/234 (33%)
		Helicase_C	349..457	CDD:278689	33/118 (28%)
		DUF4217	500..558	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910