DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vas and tdrd12

DIOPT Version :9

Sequence 1:	NP_001260458.1	Gene:	vas / 26067080	FlyBaseID:	FBgn0283442	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_021326385.1	Gene:	tdrd12 / 100334979	ZFINID:	ZDB-GENE-121214-348	Length:	1150	Species:	Danio rerio

Alignment Length:	565	Identity:	97/565 - (17%)
Similarity:	181/565 - (32%)	Gaps:	152/565 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 EDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFARRRRNEDDINNNNNIVEDVERKRE 200
            |:.....|:.|....|......:|.||                 ..|.|:....::.:.:...|.
Zfish   344 EEKQSSPGQTDDNSEGSRVYNAIDSEE-----------------LKEADLPQEPSLDDHLACARL 391

  Fly   201 F-YIPPEPSNDAIEIFSSGIA------SG--IHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDII 256
            . ::.|:|.|...|...:.:|      ||  :|.:      :::      :|..:.|.|.:.:..
Zfish   392 MQFLNPDPLNPDQETVDAKVARCDPGHSGVLVHSA------IRI------EPCSNLTRAPITEQF 444

  Fly   257 IDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTG--------------------------SGK 295
            ...:....|..|...:....|.::.|.|.:..:.:|                          :|.
Zfish   445 RKFLLWRKYSGPNVAESYCWPAVARGFDTVLVSHSGDNPLSYIPPLLMILQTVSVVSSLAARTGP 509

  Fly   296 TAAFLLP------ILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYG 354
            .|..|.|      .:.:||||........|..|::...::       |.:||.
Zfish   510 VAVILCPGWEKVQTVLELLEDSKATHGLHPTSVLLGVDQD-------EPKKFK------------ 555

  Fly   355 GTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTH 419
                      |.:.|.:::.||..||..::.....|.....:||||||.:.... .:.:..|:.|
Zfish   556 ----------IQKNCQLLVTTPFSLLRLLEAQCFLFLRLCHLVLDEADLLYSQA-PDQISIILKH 609

  Fly   420 VTMRPEHQTLMFS---ATFPEEIQRMAGEFLKNYVFVAIGIVG---------------------- 459
                  .|.|:.:   ...|.:|..:.|.:       :.||.|
Zfish   610 ------FQQLVCAEERVACPRQIIAVGGRW-------SAGIDGLVREHMIHPTVIITVMEEAALY 661

  Fly   460 GACSDVKQTIYEVNKYAKRSKLIEILSEQADGTIVFVETKRGADFLASFLSEKEFPTTSIH---G 521
            |......|...:.:|.:.....::....:...|::...:....:.:...:......|...|   .
Zfish   662 GRVHQRVQLCLDCDKVSVLLSSLDFQPPKPQKTLIITNSAEETEHVYKAVVNTAVFTLKAHEDAT 726

  Fly   522 DRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNN 586
            |:.....:|..:|...|:..:|:.|:...:.|.|::...|::|..||....:..|:   ..:..|
Zfish   727 DQFDFIIDQWRKDISQGTQVILVTTNDCLKALGIRDATCVVHYGFPSTPKLFGSRL---FCMSEN 788

  Fly   587 GRATSFFDPEKDRAIAADLVKILEGSGQTVPD------FLRTCGA 625
            .|..|..|..:|....|..|.:|  |.|.|..      :||..||
Zfish   789 FRKLSDMDHSEDWTPGAQSVLLL--SEQNVRHVCGVLRYLRRTGA 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vas	NP_001260458.1	DEADc	247..454	CDD:238167	41/241 (17%)
		DEXDc	260..467	CDD:214692	43/263 (16%)
		Helicase_C	475..584	CDD:278689	16/111 (14%)
tdrd12	XP_021326385.1	TUDOR	9..130	CDD:306940
		SrmB	463..>781	CDD:223587	58/360 (16%)
		TUDOR	912..1010	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910