DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment solo and DDX3X

DIOPT Version :9

Sequence 1:	NP_001027274.2	Gene:	solo / 26067079	FlyBaseID:	FBgn0283440	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	NP_001347.3	Gene:	DDX3X / 1654	HGNCID:	2745	Length:	662	Species:	Homo sapiens

Alignment Length:	442	Identity:	96/442 - (21%)
Similarity:	149/442 - (33%)	Gaps:	132/442 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TRGARGGD---WSD--DEDTAKSFSGEAEGDGVG------GSGGEGGGYQGGNRDVFGRIG--GG 64
            |:|....|   ||.  |:|...||...::..|..      |||..|.....|..|..| ||  |.
Human    49 TKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDG-IGSRGD 112

  Fly    65 RGGGAGGYRGGNRDGGGFHGGR---REGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEG 126
            |.|.....||||        .|   :..|.|:             |:......|..|..|.||..
Human   113 RSGFGKFERGGN--------SRWCDKSDEDDW-------------SKPLPPSERLEQELFSGGNT 156

  Fly   127 GFRGRLYEN----EDAKELPPIPSSCDKDEVGAFI-DQLDLSKYTT-------SLALIRKLRDYL 179
            |.....|::    ......||...|....|:|..| ..::|::||.       ::.:|::.||.:
Human   157 GINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLM 221

  Fly   180 LTAFKALVNQAWASLEKLAQEKRAQKAHQIRETTDMMNRLMEDMGRLIREGE------------- 231
            ..|.......|...|..|:|.........:        |.|::.||..|..:
Human   222 ACAQTGSGKTAAFLLPILSQIYSDGPGEAL--------RAMKENGRYGRRKQYPISLVLAPTREL 278

  Fly   232 ----HEEANGIGMGFQSIDADC----RADLSQWRNLQQVVMPQSSEIRDGQTN-----RTSG--- 280
                :|||.  ...::|....|    .||:.|             :|||.:..     .|.|
Human   279 AVQIYEEAR--KFSYRSRVRPCVVYGGADIGQ-------------QIRDLERGCHLLVATPGRLV 328

  Fly   281 --TEGGRSGGLTDGDDLTEIQSAAYAVYHQ---VLDRGYQTG-RRLYDDNQGALREDSIPTEDRE 339
              .|.|:.|          :....|.|..:   :||.|::.. ||:       :.:|::|.:...
Human   329 DMMERGKIG----------LDFCKYLVLDEADRMLDMGFEPQIRRI-------VEQDTMPPKGVR 376

  Fly   340 HPENNQVDGSTYGVTRFLHWLSENFVTRHEIRAV-RFGS-PHMVFQSYDWPE 389
            |   ..:..:|:  .:.:..|:.:|:..:...|| |.|| ...:.|...|.|
Human   377 H---TMMFSATF--PKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
solo	NP_001027274.2	None
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269\|PubMed:18636090	2..139		30/111 (27%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:30131165, ECO:0000269\|PubMed:31575075	12..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..144		30/116 (26%)
		Interaction with EIF4E. /evidence=ECO:0000269\|PubMed:17667941	38..44
		PTZ00110	57..580	CDD:240273	93/434 (21%)
		Interaction with VACV protein K7. /evidence=ECO:0000269\|PubMed:19913487	81..90		0/8 (0%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269\|PubMed:30256975	88..123		13/35 (37%)
		Interaction with GSK3B. /evidence=ECO:0000269\|PubMed:18846110	100..662		82/391 (21%)
		Interaction with IKBKE	100..110		5/10 (50%)
		Interaction with CHUK. /evidence=ECO:0000269\|PubMed:17667941	139..172		7/32 (22%)
		DEADc_DDX3	160..410	CDD:350809	55/294 (19%)
		Q motif	180..208		7/27 (26%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		2/16 (13%)
		DEAD box	347..350		0/2 (0%)
		Interaction with HCV core protein. /evidence=ECO:0000269\|PubMed:10329544	409..662		5/15 (33%)
		Interaction with NXF1. /evidence=ECO:0000269\|PubMed:18596238	536..661
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595675at2759
OrthoFinder	1	1.000	-	-		FOG0000634
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010