Protein Alignment solo and Ddx3x

DIOPT Version :10

• Sequence 1: NP_001027274.2
• Gene: solo / 26067079
• FlyBaseID: FBgn0283440
• Length: 1031
• Species: Drosophila melanogaster
• Sequence 2: NP_034158.1
• Gene: Ddx3x / 13205
• MGIID: 103064
• Length: 662
• Species: Mus musculus
• Alignment Length: 403
• Identity: 88/403 - (21%)
• Similarity: 142/403 - (35%)
• Gaps: 136/403 - (33%)

  Fly    71 GYRGGNRDGGGFHGGRREGER---DFRGGEGGFRGGQGGSRGGQGGSRGGQGGF-RGGEGGFRGR 131
            |.||.:|....|.|.|..|.|   |.||     ||...|. ||: |.|.|.|.| |||...:..:
Mouse    73 GSRGDSRGKSSFFGDRGSGSRGRFDDRG-----RGDYDGI-GGR-GDRSGFGKFERGGNSRWCDK 130

  Fly   132 LYENEDAKELPP-----------------------IP-----SSCDKD-------EVGAFI-DQL 160
            ..|::.:|.|||                       ||     ::|...       |:|..| ..:
Mouse   131 SDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNI 195

  Fly   161 DLSKYTT-------SLALIRKLRDYLLTAFKALVNQAWASLEKLAQEKRAQKAHQIRETTDMMNR 218
            :|::||.       ::.:|::.||.:..|.......|...|..|:|.........:        |
Mouse   196 ELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADGPGEAL--------R 252

  Fly   219 LMEDMGRLIREGE-----------------HEEANGIGMGFQSIDADC----RADLSQWRNLQQV 262
            .|::.||..|..:                 :|||.  ...::|....|    .|::.|
Mouse   253 AMKENGRYGRRKQYPISLVLAPTRELAVQIYEEAR--KFSYRSRVRPCVVYGGAEIGQ------- 308

  Fly   263 VMPQSSEIRDGQTN-----RTSG-----TEGGRSGGLTDGDDLTEIQSAAYAVYHQ---VLDRGY 314
                  :|||.:..     .|.|     .|.|:.|          :....|.|..:   :||.|:
Mouse   309 ------QIRDLERGCHLLVATPGRLVDMMERGKIG----------LDFCKYLVLDEADRMLDMGF 357

  Fly   315 QTG-RRLYDDNQGALREDSIPTEDREHPENNQVDGSTYGVTRFLHWLSENFVTRHEIRAV-RFGS 377
            :.. ||:       :.:|::|.:...|   ..:..:|:  .:.:..|:.:|:..:...|| |.||
Mouse   358 EPQIRRI-------VEQDTMPPKGVRH---TMMFSATF--PKEIQMLARDFLDEYIFLAVGRVGS 410

  Fly   378 -PHMVFQSYDWPE 389
             ...:.|...|.|
Mouse   411 TSENITQKVVWVE 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
solo	NP_001027274.2	None
Ddx3x	NP_034158.1	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571	2..139		26/72 (36%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571	12..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		30/77 (39%)
		Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571	38..44
		Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571	100..662		77/376 (20%)
		Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571	100..110		5/15 (33%)
		Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571	139..172		5/32 (16%)
		DEADc_DDX3	160..410	CDD:350809	53/294 (18%)
		Q motif	180..208		6/27 (22%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571	250..259		2/16 (13%)
		DEAD box	347..350		0/2 (0%)
		SF2_C_DEAD	415..545	CDD:350174	3/9 (33%)
		Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571	536..661
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..633