DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicC and dic1

DIOPT Version :9

Sequence 1:	NP_001303578.1	Gene:	SdicC / 26067076	FlyBaseID:	FBgn0283434	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001342791.1	Gene:	dic1 / 5802757	PomBaseID:	SPBC646.17c	Length:	544	Species:	Schizosaccharomyces pombe

Alignment Length:	579	Identity:	152/579 - (26%)
Similarity:	268/579 - (46%)	Gaps:	103/579 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVLIKFLRS-TYSTLSGGKKQPLNLS---VYN-----VQATNIPPKETLVYTKQTQTTSTGGGNG 58
            |:|:|...: |.:..|..|:.|..:|   :.|     ::.||:.|:...:.:|.:...|
pombe    16 LLLLKNKENCTDAVSSSNKEGPKQISEDQLSNFLCKILKPTNLTPQTYSLESKSSNLVS------ 74

  Fly    59 DVLAFDAQGDDEESSLQNLGNGFTSKLPPGYLTHGLPTV-KDVAPAITPLEIKKETEVKK----- 117
                      |.|..:.::...::|..   .:::.:|:: |.|....|...:|..|:..|
pombe    75 ----------DCELKISSVYQSYSSTF---NVSNHVPSISKTVNIRETSKHLKHSTKAPKCSLPT 126

  Fly   118 ---EVNELSEEQKQMIILSENFQRFVVRAGRVIERAL-SENVDIYTDYIGGGDSEEANDERSHAR 178
               |::.|:              .|:..:.::::||| .::..::|||.....|::...:.....
pombe   127 SALEIDHLN--------------NFLHSSAKILDRALCDQSNQLFTDYTVKKKSKKNKSQLEENG 177

  Fly   179 LSLNRVFYDERWSKNRCITSMDWSTHFPKLVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVF 243
            |:....|.||:.:.|..:.|:.:|:.|.:|::.||...:|: ....|:.:|||.::|.| ||.|.
pombe   178 LNHLFTFQDEKITLNSVVNSISYSSFFEELLITSYAKPKEA-LRTRGLAIVWNQRWKNS-PESVL 240

  Fly   244 HCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQN 308
            ..:|.:.....:.|:|.||.||.|:||:.|||.| |.:.|:..|.:.:..|..||..:..:....
pombe   241 KARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLR-QGQYPVSFTTIISGGHLEPVTDITYINNPP 304

  Fly   309 AHNVISISSDGKLCSWSLDMLSQPQDTLELQQR---QSKAIAITSMAF-PANEINSLVMGSEDGY 369
            ::|:::.|:||.:..|..||.|:|.:|:.|..:   .|:.|..|.::| |.|.:..|| |:|||.
pombe   305 SNNIVTCSTDGLVHIWEPDMFSRPSETICLSSQVDSSSQCIPATCLSFIPENNMEFLV-GAEDGK 368

  Fly   370 VYSASRHGLRSGVNEV---------YERHLGPITGI----STHYN---QLSPDFGHLFLTSS--- 415
            :    :.|.||..:|.         ||.|...|:||    |...|   :.:.||.   ||||
pombe   369 L----QRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFA---LTSSFDW 426

  Fly   416 -IKIWSLK--------LPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALFAAVDGS 471
             :::|...        :|.:.....|:  |||.|..    .:...:.||.|....|..||:||..
pombe   427 TVRLWQCSPSRNQHELVPSNDLDEQVI--INSCKTF----THKAMVFDVKWCVSEPCCFASVDAL 485

  Fly   472 GRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVY-DVAENLA 529
            |.|:||:|.:|.|.|..|.:..|.| ||:::|.|...::..|...|.:::| .::.|||
pombe   486 GNLNLWDLQKDVEAPVTSDIPDGKP-LNKIAWQPEKRNLACGGLNGNVHIYKHLSPNLA 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicC	NP_001303578.1	Dynein_IC2	23..51	CDD:288403	7/35 (20%)
		NtpH	108..>178	CDD:225368	13/78 (17%)
		WD40	196..523	CDD:295369	110/359 (31%)
		WD40 repeat	196..245	CDD:293791	16/48 (33%)
		WD40	<224..534	CDD:225201	106/339 (31%)
		WD40 repeat	251..289	CDD:293791	16/37 (43%)
		WD40 repeat	298..337	CDD:293791	11/38 (29%)
		WD40 repeat	349..386	CDD:293791	14/46 (30%)
		WD40 repeat	393..446	CDD:293791	18/71 (25%)
		WD40 repeat	452..491	CDD:293791	17/38 (45%)
		WD40 repeat	498..522	CDD:293791	6/23 (26%)
dic1	NP_001342791.1	WD40	223..536	CDD:330360	102/329 (31%)
		WD40 repeat	247..289	CDD:293791	16/42 (38%)
		WD40 repeat	294..339	CDD:293791	12/44 (27%)
		WD40 repeat	348..390	CDD:293791	14/46 (30%)
		WD40 repeat	397..453	CDD:293791	13/58 (22%)
		WD40 repeat	466..504	CDD:293791	16/37 (43%)
		WD40 repeat	511..535	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1109
OMA	1	1.010	-	-		QHG54336
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		otm47086
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
TreeFam	0	0.000	Not matched by this tool.
	9	8.970