DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicC and dync1i1

DIOPT Version :9

Sequence 1:	NP_001303578.1	Gene:	SdicC / 26067076	FlyBaseID:	FBgn0283434	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	545	Identity:	273/545 - (50%)
Similarity:	364/545 - (66%)	Gaps:	66/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TLSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGN 79
            ::.|.:.|.|..|  .:...:..|||.:.|:|:|||......       ..:.||||.|
Zfish   141 SVHGCRMQRLGAS--KIVQIDFMPKELVTYSKETQTPVASNQ-------PEEEDDEELS------ 190

  Fly    80 GFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVN--ELSEEQKQMIILSENFQRFVVR 142
                             |....||...||.:|..|| :||:  ||:.|:|:.|:.||:|..|..|
Zfish   191 -----------------VPKSEPASQQLEEEKTQEV-EEVHPRELTNEEKEQIVHSEDFLFFFDR 237

  Fly   143 AGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPK 207
            :.||:||.|:|:.||:.||.|....::..|.::.:.||.||.||||.|||:|.:||:|||..:|:
Zfish   238 SIRVVERVLAEDKDIFFDYSGRDMEDKEGDLQAGSNLSFNRHFYDEHWSKHRVVTSLDWSPQYPE 302

  Fly   208 LVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIV 272
            |:|.||:.||::|:||||||:|||.||||:|||.:|||||:|||..||:|:|||::||||||||.
Zfish   303 LLVASYNTNEDAPHEPDGVVLVWNMKFKKATPEYIFHCQSSVMSVGFAQFHPNLVIGGTYSGQIA 367

  Fly   273 LWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLE 337
            :||||..:|||:|||||||.||||||||:.:||||||:|:|::|:|||:||||||||||||:::|
Zfish   368 MWDNRSHRRTPVQRTPLSATAHTHPVYCVNVVGTQNANNLITVSTDGKMCSWSLDMLSQPQESME 432

  Fly   338 LQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQ 402
            |...:||.:|:|.|||||:::|:.|:|||:|.||:|||||.::|:.|:::.|.||:||||.| |.
Zfish   433 LIYNKSKPVAVTCMAFPASDVNNYVVGSEEGTVYTASRHGSKAGIGEIFDGHQGPVTGISCH-NA 496

  Fly   403 LSP-DFGHLFLTSS----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHP 462
            :.| ||.|||.|||    :|:||.|               .||||||||||:||:.||.||||||
Zfish   497 VGPVDFSHLFTTSSFDWTVKLWSTK---------------HNKPLYSFEDNADYVYDVMWSPVHP 546

  Fly   463 ALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAEN 527
            ||||.|||:|||||||||..||||:||:.|.|..|||||.|...|..|.:||..|::::|||.|.
Zfish   547 ALFATVDGNGRLDLWNLNNYTEVPSASVSVEGGCALNRVRWASGGREVAVGDSEGRVWIYDVGEQ 611

  Fly   528 LAQPSRD----------EIKMNQSD 542
            ||.|..|          ||:.|:.|
Zfish   612 LAVPHTDDWSKFGRTLMEIQANRGD 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicC	NP_001303578.1	Dynein_IC2	23..51	CDD:288403	9/27 (33%)
		NtpH	108..>178	CDD:225368	28/71 (39%)
		WD40	196..523	CDD:295369	200/331 (60%)
		WD40 repeat	196..245	CDD:293791	30/48 (63%)
		WD40	<224..534	CDD:225201	192/314 (61%)
		WD40 repeat	251..289	CDD:293791	25/37 (68%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..386	CDD:293791	21/36 (58%)
		WD40 repeat	393..446	CDD:293791	25/57 (44%)
		WD40 repeat	452..491	CDD:293791	30/38 (79%)
		WD40 repeat	498..522	CDD:293791	10/23 (43%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403	10/29 (34%)
		WD40	215..608	CDD:225201	235/408 (58%)
		WD40	284..607	CDD:295369	204/338 (60%)
		WD40 repeat	292..337	CDD:293791	29/44 (66%)
		WD40 repeat	347..388	CDD:293791	28/40 (70%)
		WD40 repeat	394..437	CDD:293791	28/42 (67%)
		WD40 repeat	443..490	CDD:293791	24/46 (52%)
		WD40 repeat	498..530	CDD:293791	19/46 (41%)
		WD40 repeat	536..574	CDD:293791	29/37 (78%)
		WD40 repeat	582..608	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I842
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm6471
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910