DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicC and Dync1i1

DIOPT Version :9

Sequence 1:	NP_001303578.1	Gene:	SdicC / 26067076	FlyBaseID:	FBgn0283434	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_062107.2	Gene:	Dync1i1 / 29564	RGDID:	2512	Length:	643	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	272/531 - (51%)
Similarity:	354/531 - (66%)	Gaps:	58/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90
            |.|..|...:..|:|.:.|:|:|||        .:....::.|:|:..:.....|..|:|..
  Rat   146 LGVSKVTQVDFLPREVVSYSKETQT--------PLATHQSEEDEEDEEMVEPKVGHDSELEN--- 199

  Fly    91 THGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENV 155
                             :.||:...:....||:||:||.|:.||.|..|..|..|||||||:|:.
  Rat   200 -----------------QDKKQETKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDS 247

  Fly   156 DIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPKLVVGSYHNNEESP 220
            ||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|:|:|.||.|||::|
  Rat   248 DIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAP 312

  Fly   221 NEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQ 285
            :|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:|
  Rat   313 HEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQ 377

  Fly   286 RTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITS 350
            |||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|.
  Rat   378 RTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTG 442

  Fly   351 MAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSS 415
            ||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:|||
  Rat   443 MAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSS 507

  Fly   416 ----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALFAAVDGSGRLDL 476
                :|:|:.|               .||||||||||:||:.||.||||||||||.|||.|||||
  Rat   508 FDWTVKLWTTK---------------HNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDL 557

  Fly   477 WNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRD------- 534
            ||||.||||||||:.:.||.|||||.|...|..|.:||..|::::|||.| ||.|..|
  Rat   558 WNLNSDTEVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGE-LAVPHNDEWTRFAR 621

  Fly   535 ---EIKMNQSD 542
               ||:.|::|
  Rat   622 TLVEIRANRAD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicC	NP_001303578.1	Dynein_IC2	23..51	CDD:288403	9/24 (38%)
		NtpH	108..>178	CDD:225368	29/69 (42%)
		WD40	196..523	CDD:295369	203/330 (62%)
		WD40 repeat	196..245	CDD:293791	31/48 (65%)
		WD40	<224..534	CDD:225201	194/313 (62%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..386	CDD:293791	19/36 (53%)
		WD40 repeat	393..446	CDD:293791	21/56 (38%)
		WD40 repeat	452..491	CDD:293791	32/38 (84%)
		WD40 repeat	498..522	CDD:293791	10/23 (43%)
Dync1i1	NP_062107.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
		Interaction with DCTN1	2..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..123
		Dynein_IC2	145..171	CDD:402922	10/32 (31%)
		Interaction with DYNLT1. /evidence=ECO:0000250\|UniProtKB:O14576	145..161		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..219		14/79 (18%)
		WD40	281..604	CDD:421866	207/337 (61%)
		WD 1	283..332		30/48 (63%)
		WD40 repeat	289..335	CDD:293791	29/45 (64%)
		WD 2	336..376		30/39 (77%)
		WD40 repeat	344..383	CDD:293791	29/38 (76%)
		WD 3	385..426		31/40 (78%)
		WD40 repeat	391..432	CDD:293791	28/40 (70%)
		WD 4	435..475		21/39 (54%)
		WD40 repeat	440..479	CDD:293791	20/38 (53%)
		WD 5	480..525		22/59 (37%)
		WD40 repeat	486..527	CDD:293791	21/55 (38%)
		WD 6	528..568		32/39 (82%)
		WD40 repeat	533..571	CDD:293791	31/37 (84%)
		WD 7	574..613		20/39 (51%)
		WD40 repeat	579..605	CDD:293791	11/25 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334323
Domainoid	1	1.000	378	1.000	Domainoid score	I818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I852
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm9006
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910