DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicC and DYNC1I2

DIOPT Version :9

Sequence 1:	NP_001303578.1	Gene:	SdicC / 26067076	FlyBaseID:	FBgn0283434	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001258714.1	Gene:	DYNC1I2 / 1781	HGNCID:	2964	Length:	638	Species:	Homo sapiens

Alignment Length:	542	Identity:	278/542 - (51%)
Similarity:	371/542 - (68%)	Gaps:	71/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPP 87
            |:.|.:..:...:.||:|.:.|||:|||        .|:|...:.::|:..:
Human   135 PIKLGMAKITQVDFPPREIVTYTKETQT--------PVMAQPKEDEEEDDDV------------- 178

  Fly    88 GYLTHGLPTVKDVAPAITPLEIKKETEVKKE--------VNELSEEQKQMIILSENFQRFVVRAG 144
                        |||. .|:|.::|..:||:        .:||:||:||.|:.||.|..|...:.
Human   179 ------------VAPK-PPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHST 230

  Fly   145 RVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPKLV 209
            |::||||||.::|:.||.|....::..:.::.|:|||||.|:||||||:|.::.:|||:.:|:|:
Human   231 RIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELL 295

  Fly   210 VGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLW 274
            |.||:|||::|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||||||||||
Human   296 VASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW 360

  Fly   275 DNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ 339
            |||..||||:||||||||||||||||:.:||||||||:||||:|||:|||||||||.|||::||.
Human   361 DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELV 425

  Fly   340 QRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLS 404
            .:||||:|:|||:||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:
Human   426 HKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 490

  Fly   405 PDFGHLFLTSS----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALF 465
            .||.|||:|||    :|:|:.|               :||||||||||:||:.||.|||.|||||
Human   491 VDFSHLFVTSSFDWTVKLWTTK---------------NNKPLYSFEDNADYVYDVMWSPTHPALF 540

  Fly   466 AAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQ 530
            |.|||.|||||||||.|||||||||.|.|.||||||.||.||..:.:||..|::.:|||.|.:|.
Human   541 ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAV 605

  Fly   531 PSRD----------EIKMNQSD 542
            |..|          ||..|::|
Human   606 PRNDEWARFGRTLAEINANRAD 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicC	NP_001303578.1	Dynein_IC2	23..51	CDD:288403	10/27 (37%)
		NtpH	108..>178	CDD:225368	26/77 (34%)
		WD40	196..523	CDD:295369	209/330 (63%)
		WD40 repeat	196..245	CDD:293791	28/48 (58%)
		WD40	<224..534	CDD:225201	201/313 (64%)
		WD40 repeat	251..289	CDD:293791	29/37 (78%)
		WD40 repeat	298..337	CDD:293791	30/38 (79%)
		WD40 repeat	349..386	CDD:293791	19/36 (53%)
		WD40 repeat	393..446	CDD:293791	22/56 (39%)
		WD40 repeat	452..491	CDD:293791	31/38 (82%)
		WD40 repeat	498..522	CDD:293791	11/23 (48%)
DYNC1I2	NP_001258714.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135		278/542 (51%)
		Dynein_IC2	135..163	CDD:402922	11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..214		21/92 (23%)
		WD 1	277..326		27/48 (56%)
		WD40 repeat	282..331	CDD:293791	28/48 (58%)
		WD40	329..>599	CDD:225201	183/284 (64%)
		WD 2	330..370		32/39 (82%)
		WD40 repeat	339..377	CDD:293791	30/37 (81%)
		WD 3	379..420		33/40 (83%)
		WD40 repeat	385..426	CDD:293791	31/40 (78%)
		WD 4	429..469		22/39 (56%)
		WD40 repeat	434..481	CDD:293791	24/46 (52%)
		WD 5	474..519		23/59 (39%)
		WD40 repeat	489..521	CDD:293791	17/46 (37%)
		WD 6	522..562		31/39 (79%)
		WD40 repeat	527..565	CDD:293791	30/37 (81%)
		WD 7	568..607		19/38 (50%)
		WD40 repeat	573..599	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140645
Domainoid	1	1.000	377	1.000	Domainoid score	I864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	600	1.000	Inparanoid score	I957
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm8531
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910