Protein Alignment SdicC and DYNC1I2

DIOPT Version :10

• Sequence 1: NP_001303578.1
• Gene: SdicC / 26067076
• FlyBaseID: FBgn0283434
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001369.1
• Gene: DYNC1I2 / 1781
• HGNCID: 2964
• Length: 638
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 278/542 - (51%)
• Similarity: 371/542 - (68%)
• Gaps: 71/542 - (13%)

  Fly    23 PLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPP 87
            |:.|.:..:...:.||:|.:.|||:|||        .|:|...:.::|:..:
Human   135 PIKLGMAKITQVDFPPREIVTYTKETQT--------PVMAQPKEDEEEDDDV------------- 178

  Fly    88 GYLTHGLPTVKDVAPAITPLEIKKETEVKKE--------VNELSEEQKQMIILSENFQRFVVRAG 144
                        |||. .|:|.::|..:||:        .:||:||:||.|:.||.|..|...:.
Human   179 ------------VAPK-PPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHST 230

  Fly   145 RVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPKLV 209
            |::||||||.::|:.||.|....::..:.::.|:|||||.|:||||||:|.::.:|||:.:|:|:
Human   231 RIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELL 295

  Fly   210 VGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLW 274
            |.||:|||::|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||||||||||
Human   296 VASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW 360

  Fly   275 DNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ 339
            |||..||||:||||||||||||||||:.:||||||||:||||:|||:|||||||||.|||::||.
Human   361 DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELV 425

  Fly   340 QRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLS 404
            .:||||:|:|||:||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:
Human   426 HKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 490

  Fly   405 PDFGHLFLTSS----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALF 465
            .||.|||:|||    :|:|:.|               :||||||||||:||:.||.|||.|||||
Human   491 VDFSHLFVTSSFDWTVKLWTTK---------------NNKPLYSFEDNADYVYDVMWSPTHPALF 540

  Fly   466 AAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQ 530
            |.|||.|||||||||.|||||||||.|.|.||||||.||.||..:.:||..|::.:|||.|.:|.
Human   541 ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAV 605

  Fly   531 PSRD----------EIKMNQSD 542
            |..|          ||..|::|
Human   606 PRNDEWARFGRTLAEINANRAD 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdicC	NP_001303578.1	Dynein_IC2	21..51	CDD:463291	10/27 (37%)
		WD40	196..523	CDD:475233	209/330 (63%)
		WD40 repeat	196..245	CDD:293791	28/48 (58%)
		WD40 repeat	251..289	CDD:293791	29/37 (78%)
		WD40 repeat	298..337	CDD:293791	30/38 (79%)
		WD40 repeat	349..386	CDD:293791	19/36 (53%)
		WD40 repeat	393..446	CDD:293791	22/56 (39%)
		WD40 repeat	452..491	CDD:293791	31/38 (82%)
		WD40 repeat	498..522	CDD:293791	11/23 (48%)
DYNC1I2	NP_001369.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		278/542 (51%)
		Dynein_IC2	133..163	CDD:463291	11/35 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..214		21/92 (23%)
		WD 1	277..326		27/48 (56%)
		WD40 repeat	282..331	CDD:293791	28/48 (58%)
		WD40	<310..413	CDD:441893	82/102 (80%)
		WD 2	330..370		32/39 (82%)
		WD40 repeat	339..377	CDD:293791	30/37 (81%)
		WD 3	379..420		33/40 (83%)
		WD40	380..>605	CDD:475233	143/239 (60%)
		WD40 repeat	385..426	CDD:293791	31/40 (78%)
		WD 4	429..469		22/39 (56%)
		WD40 repeat	434..481	CDD:293791	24/46 (52%)
		WD 5	474..519		23/59 (39%)
		WD40 repeat	489..521	CDD:293791	17/46 (37%)
		WD 6	522..562		31/39 (79%)
		WD40 repeat	527..565	CDD:293791	30/37 (81%)
		WD 7	568..607		19/38 (50%)
		WD40 repeat	573..599	CDD:293791	12/25 (48%)