DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SdicB and PFS2

DIOPT Version :9

Sequence 1:	NP_001303577.1	Gene:	SdicB / 26067075	FlyBaseID:	FBgn0283433	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_014082.1	Gene:	PFS2 / 855399	SGDID:	S000005261	Length:	465	Species:	Saccharomyces cerevisiae

Alignment Length:	364	Identity:	78/364 - (21%)
Similarity:	137/364 - (37%)	Gaps:	63/364 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 VIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVV 210
            |:|...|..:||.......|.....|.......||.|:|        ...|.::.|:.....|||
Yeast    54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKV--------KHVIPAIQWTPEGRRLVV 110

  Fly   211 GSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWD 275
            .:|          .|...:||.  ...|.|.:.....:.::|.....:.:.::.|...|.|.:|.
Yeast   111 ATY----------SGEFSLWNA--SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163

  Fly   276 NRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQ 340
            ........|.      ||||..:  ..|..:.|....::.|.|..|..|:..           ..
Yeast   164 PNFSMVKEID------AAHTESI--RDMAFSSNDSKFVTCSDDNILKIWNFS-----------NG 209

  Fly   341 RQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGL------RSG--VNEVYE-RHLGPITGI 396
            :|.:.::....     ::.|.....|.|.:.|||:..|      |||  ::.:.: :|    |.:
Yeast   210 KQERVLSGHHW-----DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH----TVL 265

  Fly   397 STHYNQLSPDFGHLFLTSSIDWTIKLWSLK-DTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGS 460
            .|.:   .|..|:|.:..|.|.:.:::.:: ..|.|....|.:|| |.:.|.|::.::|......
Yeast   266 KTRF---QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY-MTLEWHPINESMFTLACYD 326

  Fly   461 GRLDLWNLNQDTEVPIASIVVAGAPALNRVSWTPSGLHV 499
            |.|..::|.|:...||.:|..|....:..:|:.|.| |:
Yeast   327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG-HI 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicB	NP_001303577.1	Dynein_IC2	23..51	CDD:288403
		NtpH	108..>178	CDD:225368	7/31 (23%)
		WD40	196..512	CDD:295369	67/314 (21%)
		WD40 repeat	196..245	CDD:293791	11/48 (23%)
		WD40	<224..523	CDD:225201	61/286 (21%)
		WD40 repeat	251..289	CDD:293791	6/37 (16%)
		WD40 repeat	298..337	CDD:293791	6/38 (16%)
		WD40 repeat	349..435	CDD:293791	20/95 (21%)
		WD40 repeat	441..479	CDD:293791	10/37 (27%)
		WD40 repeat	487..513	CDD:293791	4/13 (31%)
PFS2	NP_014082.1	WD40	93..377	CDD:238121	67/317 (21%)
		WD40 repeat	98..133	CDD:293791	10/46 (22%)
		WD40 repeat	139..175	CDD:293791	6/41 (15%)
		WD40 repeat	180..216	CDD:293791	7/48 (15%)
		WD40 repeat	223..257	CDD:293791	10/33 (30%)
		WD40 repeat	264..299	CDD:293791	7/37 (19%)
		WD40 repeat	307..346	CDD:293791	11/39 (28%)
		WD40 repeat	353..377	CDD:293791	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910