Protein Alignment SdicB and Dync1i2

DIOPT Version :10

• Sequence 1: NP_001303577.1
• Gene: SdicB / 26067075
• FlyBaseID: FBgn0283433
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_446332.2
• Gene: Dync1i2 / 116659
• RGDID: 620174
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 282/510 - (55%)
• Similarity: 364/510 - (71%)
• Gaps: 42/510 - (8%)

  Fly    23 PLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPP 87
            |:.|.:..:...:.||:|.:.|||:|||..|.         ..:.|:||..
  Rat   135 PIKLGMAKITQVDFPPREIVTYTKETQTPVTA---------QPKEDEEEED-------------- 176

  Fly    88 GYLTHGLPTVKDVAPAITPLEIKKETEVKKE--------VNELSEEQKQMIILSENFQRFVVRAG 144
                       |||....|:|.::|..:||:        .:||:||:||.|:.||.|..|...:.
  Rat   177 -----------DVAAPKPPVEPEEEKILKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHST 230

  Fly   145 RVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELV 209
            |::||||||.::|:.||.|....::..:.::.|:|||||.|:||||||:|.::.:|||:.:|||:
  Rat   231 RIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELL 295

  Fly   210 VGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLW 274
            |.||:||||:|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||||||||||
  Rat   296 VASYNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW 360

  Fly   275 DNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ 339
            |||..||||:||||||||||||||||:.:||||||||:||||:|||:|||||||||.|||::||.
  Rat   361 DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELV 425

  Fly   340 QRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLS 404
            .:||||:|:|||:||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:
  Rat   426 HKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 490

  Fly   405 PDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLN 469
            .||.|||:|||.|||:|||:.|:.|||||||||||||.||.|||.||||||.|||.|||||||||
  Rat   491 VDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLN 555

  Fly   470 QDTEVPIASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 524
            .|||||.|||.|.|.||||||.||.||..:.:||..|::.:|||.|.:|.|..||
  Rat   556 NDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDE 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdicB	NP_001303577.1	Dynein_IC2	21..51	CDD:463291	10/27 (37%)
		WD40	196..512	CDD:475233	215/315 (68%)
		WD40 repeat	196..245	CDD:293791	30/48 (63%)
		WD40 repeat	251..289	CDD:293791	29/37 (78%)
		WD40 repeat	298..337	CDD:293791	30/38 (79%)
		WD40 repeat	349..435	CDD:293791	48/85 (56%)
		WD40 repeat	441..479	CDD:293791	30/37 (81%)
		WD40 repeat	487..513	CDD:293791	12/25 (48%)
Dync1i2	NP_446332.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		282/510 (55%)
		Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274	133..165		11/29 (38%)
		Dynein_IC2	133..163	CDD:463291	10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..209		19/88 (22%)
		WD 1	277..326		29/48 (60%)
		WD40 repeat	282..331	CDD:293791	30/48 (63%)
		WD40	<310..413	CDD:441893	82/102 (80%)
		WD 2	330..370		32/39 (82%)
		WD40 repeat	339..377	CDD:293791	30/37 (81%)
		WD 3	379..420		33/40 (83%)
		WD40	380..>605	CDD:475233	147/224 (66%)
		WD40 repeat	385..426	CDD:293791	31/40 (78%)
		WD 4	429..469		22/39 (56%)
		WD40 repeat	434..481	CDD:293791	24/46 (52%)
		WD 5	474..519		26/44 (59%)
		WD40 repeat	489..521	CDD:293791	20/31 (65%)
		WD40 repeat	527..565	CDD:293791	30/37 (81%)
		WD 6	568..607		19/38 (50%)
		WD40 repeat	573..599	CDD:293791	12/25 (48%)