DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicB and dync1i1

DIOPT Version :9

Sequence 1:	NP_001303577.1	Gene:	SdicB / 26067075	FlyBaseID:	FBgn0283433	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001106382.1	Gene:	dync1i1 / 100127187	XenbaseID:	XB-GENE-490874	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	271/504 - (53%)
Similarity:	355/504 - (70%)	Gaps:	35/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPG 88
            :.|.|..|...:..|:|.:.|:|:|||        .|.....:.::|:..:.:|.....|:
Frog   129 IKLGVSKVTQVDFLPREVVSYSKETQT--------PVTTHQTEEEEEDEEMVDLKTEHDSE---- 181

  Fly    89 YLTHGLPTVKDVAPAITPLEIKKETEVKKEV--NELSEEQKQMIILSENFQRFVVRAGRVIERAL 151
                              .|.::|.:..:||  .||:||:||.:..||.|..|..|..|||||||
Frog   182 ------------------FENQEEKQDSREVPPRELTEEEKQQVTHSEEFLIFFDRTIRVIERAL 228

  Fly   152 SENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNN 216
            :|:.:|:.||.|....::..|.::.|.||.||.||||.|||:|.:|.:|||..:|||:|.||:||
Frog   229 AEDSNIFFDYSGRDLEDKEGDIQAGANLSFNRQFYDEHWSKHRVVTCLDWSLQYPELMVASYNNN 293

  Fly   217 EESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKR 281
            |::|:|||||.:|||.||:|:|||.:|||||:|||.|||:|:|||::||||||||||||||..:|
Frog   294 EDAPHEPDGVALVWNMKFRKTTPEYIFHCQSSVMSVCFARFHPNLVIGGTYSGQIVLWDNRSHRR 358

  Fly   282 TPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAI 346
            ||:|||||||||||||:||:.:||||||||:|::|:|||||||||||||.||:::||...:||.:
Frog   359 TPVQRTPLSAAAHTHPIYCVNVVGTQNAHNLITVSTDGKLCSWSLDMLSAPQESMELVYNKSKPV 423

  Fly   347 AITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSP-DFGHL 410
            |:|.||||..::|:.|:|||:|.||:|.|||.::|::||:|.|.||:|||:.| |.:.| ||.||
Frog   424 AVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGISEVFEGHQGPVTGINCH-NAVGPIDFSHL 487

  Fly   411 FLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVP 475
            |||||.|||:|||:.|..|||||||||:|||.||.||||||||||.|||.|||||||||.|||||
Frog   488 FLTSSFDWTVKLWTTKHNKPLYSFEDNADYVCDVTWSPVHPALFACVDGMGRLDLWNLNNDTEVP 552

  Fly   476 IASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 524
            .||..|.||.|||||.|..||..|.:||..|::::|||.| .:.|..||
Frog   553 TASTAVEGASALNRVRWAQSGKEVAVGDSEGRVWIYDVGE-FSIPHNDE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicB	NP_001303577.1	Dynein_IC2	23..51	CDD:288403	9/26 (35%)
		NtpH	108..>178	CDD:225368	28/71 (39%)
		WD40	196..512	CDD:295369	209/316 (66%)
		WD40 repeat	196..245	CDD:293791	29/48 (60%)
		WD40	<224..523	CDD:225201	198/299 (66%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..435	CDD:293791	51/86 (59%)
		WD40 repeat	441..479	CDD:293791	31/37 (84%)
		WD40 repeat	487..513	CDD:293791	12/25 (48%)
dync1i1	NP_001106382.1	Dynein_IC2	129..156	CDD:288403	10/34 (29%)
		WD40	180..598	CDD:225201	256/441 (58%)
		BALF1	<221..>276	CDD:115513	27/54 (50%)
		WD40	266..589	CDD:295369	213/323 (66%)
		WD40 repeat	274..319	CDD:293791	28/44 (64%)
		WD40 repeat	329..368	CDD:293791	29/38 (76%)
		WD40 repeat	376..419	CDD:293791	29/42 (69%)
		WD40 repeat	425..464	CDD:293791	20/38 (53%)
		WD40 repeat	480..512	CDD:293791	22/31 (71%)
		WD40 repeat	518..556	CDD:293791	31/37 (84%)
		WD40 repeat	564..590	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	376	1.000	Domainoid score	I857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	613	1.000	Inparanoid score	I890
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm9426
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.050