DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicA and dync1i2a

DIOPT Version :9

Sequence 1:	NP_001303576.1	Gene:	SdicA / 26067074	FlyBaseID:	FBgn0283432	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_017213212.2	Gene:	dync1i2a / 767729	ZFINID:	ZDB-GENE-060929-1086	Length:	626	Species:	Danio rerio

Alignment Length:	532	Identity:	287/532 - (53%)
Similarity:	375/532 - (70%)	Gaps:	52/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YSTLSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNL 77
            :|.|..|   ||.|::..:...:.||||.:.|||:|||.:          ...|.|:|:.
Zfish   119 HSELGRG---PLKLAMTKMTHVDFPPKEVVSYTKETQTPT----------MTEQKDEEDE----- 165

  Fly    78 GNGFTSKLPPGYLTHGLPTVKDVAPAITP-LEIKKETEVKKEV-----NELSEEQKQMIILSENF 136
                                ::..||..| .|.:||...:|:|     :||:||:|..|:.||.|
Zfish   166 --------------------EEETPAAQPEAETEKEKPEEKQVEEALPHELTEEEKLQILHSEEF 210

  Fly   137 QRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDW 201
            ..|...:.|::||||||:||::.||.|....|:..:.::..:|||||.|.|:||||.|.:|.:||
Zfish   211 MDFFDHSTRIVERALSEHVDVFFDYSGRDMEEKEGEMQAGTKLSLNRKFVDDRWSKQRVVTCLDW 275

  Fly   202 STHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGT 266
            |..:|||:|.||:||||:|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||
Zfish   276 SPQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKATPEYVFHCQSAVMSAAFAKFHPNLVVGGT 340

  Fly   267 YSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQ 331
            |||||||||||..:|||:||||||||||||||||:.:||||||||:||||:|||:||||||||||
Zfish   341 YSGQIVLWDNRSNRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKMCSWSLDMLSQ 405

  Fly   332 PQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGI 396
            |||::||..:|||::|:|||:||..::|:.|:|||||.||:|||||.|:|::|::|.|.||||||
Zfish   406 PQDSMELVFKQSKSVAVTSMSFPLGDVNNFVVGSEDGSVYTASRHGSRAGISEMFEGHHGPITGI 470

  Fly   397 STHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSG 461
            ..|......||.|||||:|.|||:||||.|:.|||||||||||||.||.||||||||||.|||.|
Zfish   471 HCHTAAGPVDFSHLFLTASFDWTVKLWSNKNNKPLYSFEDNSDYVYDVMWSPVHPALFACVDGLG 535

  Fly   462 RLDLWNLNQDTEVPIASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE-- 524
            |:||||||.|||||.||:.|.|:|||||:.|:.||..:.:||..|::::|||.|.:|.|..||
Zfish   536 RVDLWNLNNDTEVPTASVAVDGSPALNRLRWSQSGREIAVGDSEGQIHIYDVGEQIAVPRNDEWT 600

  Fly   525 ------IKMNQS 530
                  :::|::
Zfish   601 RFVRTLVEINEN 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicA	NP_001303576.1	Dynein_IC2	23..51	CDD:288403	12/27 (44%)
		NtpH	108..>178	CDD:225368	28/74 (38%)
		WD40	196..512	CDD:295369	216/315 (69%)
		WD40 repeat	196..245	CDD:293791	31/48 (65%)
		WD40	<224..523	CDD:225201	205/298 (69%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	31/38 (82%)
		WD40 repeat	349..435	CDD:293791	52/85 (61%)
		WD40 repeat	441..479	CDD:293791	30/37 (81%)
		WD40 repeat	487..513	CDD:293791	10/25 (40%)
dync1i2a	XP_017213212.2	Dynein_IC2	126..154	CDD:402922	12/27 (44%)
		WD40	269..586	CDD:421866	216/316 (68%)
		WD40 repeat	270..317	CDD:293791	29/46 (63%)
		WD40 repeat	324..363	CDD:293791	29/38 (76%)
		WD40 repeat	372..415	CDD:293791	33/42 (79%)
		WD40 repeat	423..461	CDD:293791	22/37 (59%)
		WD40 repeat	470..509	CDD:293791	23/38 (61%)
		WD40 repeat	515..542	CDD:293791	21/26 (81%)
		WD40 repeat	561..587	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573334
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I842
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm6471
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900