DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SdicA and CG14838

DIOPT Version :9

Sequence 1:	NP_001303576.1	Gene:	SdicA / 26067074	FlyBaseID:	FBgn0283432	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	129/669 - (19%)
Similarity:	211/669 - (31%)	Gaps:	265/669 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NVQATNIPPKETLVYTKQTQTTSTGGGNG----------DVLAFDAQGDDEESSLQNLGNGFTSK 84
            ||...:.|||    ..::.||..|...|.          :.|..|....|||...:.      ::
  Fly   269 NVSVQSAPPK----IEREQQTNPTFPSNAWSQYLYEIDDEDLELDETDVDEEEEKKK------AQ 323

  Fly    85 LPPGYLTHGLPTVKDVAPAITPLEIKKETEV---KKEVNELSEEQKQMIILSENFQRFVVRAGRV 146
            ..||  |:       |.|...|.|:..:.|:   ..|.|::...:....::|
  Fly   324 AKPG--TY-------VEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDYSLIS------------- 366

  Fly   147 IERALSENVDIYTD-YIGGGDSEE----ANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFP 206
                 |..|..||: |:     :|    ||..:|:.|.                :...||.....
  Fly   367 -----SRQVVQYTNPYL-----QEFLCFANISKSNKRF----------------VAGYDWYPKLS 405

  Fly   207 ELVVGSYHNN-----EESPNEPDGV---------VMVW----NTKFKKSTPEDVFHCQSAVMSTC 253
            .|:..||..:     .|:.|..|.|         |::|    |..:|..     |.......:..
  Fly   406 GLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLE-----FEAPIETTALT 465

  Fly   254 FAKFNPNLILGGTYSGQIVLWD--NRVQKRTPIQRTPLSAAAHTHPVYCLQMVG----------- 305
            |..||.:::|||:.:||:||||  .|.:|..  :...|:||...:.:    |:|
  Fly   466 FCPFNGDILLGGSKNGQVVLWDLQGRCEKLD--EEEYLTAAQAKYRI----MIGEFLNWTIDIED 524

  Fly   306 ------------------------------------------TQNAHN-VISISSDGKLCSWSLD 327
                                                      .:|.|. .::.:.||.:..|.||
  Fly   525 NVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKFFVTCAFDGTISFWDLD 589

  Fly   328 --------------MLSQPQDTLELQQRQS--KAIAIT---SMAFP------------------- 354
                          ||.:     ||.|.:|  |::.|.   ::.||
  Fly   590 GKGGKSAKDKMRNRMLPK-----ELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPV 649

  Fly   355 -----ANEIN---------------SLVMGSEDGYVYSASRHG--LRSGVNEVYER-------HL 390
                 ||..|               |:::.:..|:|......|  ......||...       |.
  Fly   650 AKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHD 714

  Fly   391 GPITGISTHYNQLSPDFGHLFLTSSIDWTI-KLWSLK-DTKPLYSFEDNSDYVMDVAWSPVHPAL 453
            ||:..:     :.:|.:..||  :||..|| .:|... :..|::..:...| :..||||...||:
  Fly   715 GPVVMV-----KKNPFYPELF--ASIGRTILAIWKEDYNYSPIFWRKRACD-LTAVAWSETRPAV 771

  Fly   454 FAAVDGSGRLDLWN-LNQDTEVPIASIVVAG--------APALN-------------RVSWTPSG 496
            .......|.|:.|: |.:|.:..:..|:..|        .|:|.             |:...|..
  Fly   772 LYLTRIDGILEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRMVKLPHS 836

  Fly   497 LHVCIGDEAGKLYVYDVAE 515
            ..|.:.:|..:|..|.:.|
  Fly   837 FDVPLPNELDQLIKYVLKE 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SdicA	NP_001303576.1	Dynein_IC2	23..51	CDD:288403	6/20 (30%)
		NtpH	108..>178	CDD:225368	14/77 (18%)
		WD40	196..512	CDD:295369	92/480 (19%)
		WD40 repeat	196..245	CDD:293791	14/66 (21%)
		WD40	<224..523	CDD:225201	87/452 (19%)
		WD40 repeat	251..289	CDD:293791	14/39 (36%)
		WD40 repeat	298..337	CDD:293791	11/106 (10%)
		WD40 repeat	349..435	CDD:293791	23/138 (17%)
		WD40 repeat	441..479	CDD:293791	11/38 (29%)
		WD40 repeat	487..513	CDD:293791	7/38 (18%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	59/327 (18%)
		WD40 repeat	462..505	CDD:293791	16/44 (36%)
		WD40 repeat	510..547	CDD:293791	2/40 (5%)
		RE_R_Pab1	807..>863	CDD:286594	9/49 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940