Protein Alignment SdicA and Dync1i1

DIOPT Version :10

• Sequence 1: NP_001303576.1
• Gene: SdicA / 26067074
• FlyBaseID: FBgn0283432
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001396540.1
• Gene: Dync1i1 / 13426
• MGIID: 107743
• Length: 645
• Species: Mus musculus
• Alignment Length: 521
• Identity: 281/521 - (53%)
• Similarity: 357/521 - (68%)
• Gaps: 49/521 - (9%)

  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90
            |.|..|...:..|:|.:.|:|:|||.         ||.....:|||..
Mouse   148 LGVSKVTQVDFLPREVVSYSKETQTP---------LATHQSEEDEEDE----------------- 186

  Fly    91 THGLPTVKDVAPAI---TPLEIKKETEVKKEV--NELSEEQKQMIILSENFQRFVVRAGRVIERA 150
                   :.|.|.|   :.||.:::.:..||.  .||:||:||.|:.||.|..|..|..||||||
Mouse   187 -------EMVEPKIGHDSELENQEKKQETKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERA 244

  Fly   151 LSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHN 215
            |:|:.||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||.|
Mouse   245 LAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSN 309

  Fly   216 NEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQK 280
            ||::|:|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:
Mouse   310 NEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHR 374

  Fly   281 RTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKA 345
            |||:||||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.
Mouse   375 RTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKP 439

  Fly   346 IAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHL 410
            :|:|.||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.||
Mouse   440 VAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHL 504

  Fly   411 FLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVP 475
            |:|||.|||:|||:.|..|||||||||:|||.||.||||||||||.|||.|||||||||.|||||
Mouse   505 FVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEVP 569

  Fly   476 IASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRD----------EIKMNQS 530
            .||:.:.||.|||||.|...|..|.:||..|::::|||.| ||.|..|          ||:.|::
Mouse   570 TASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGE-LAVPHNDEWTRFARTLVEIRANRA 633

  Fly   531 D 531
            |
Mouse   634 D 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SdicA	NP_001303576.1	Dynein_IC2	21..51	CDD:463291	9/24 (38%)
		WD40	196..512	CDD:475233	207/315 (66%)
		WD40 repeat	196..245	CDD:293791	32/48 (67%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..435	CDD:293791	48/85 (56%)
		WD40 repeat	441..479	CDD:293791	31/37 (84%)
		WD40 repeat	487..513	CDD:293791	11/25 (44%)
Dync1i1	NP_001396540.1	Dynein_IC2	143..173	CDD:463291	9/24 (38%)
		WD40 repeat	291..337	CDD:293791	30/45 (67%)
		WD40	<318..607	CDD:441893	191/288 (66%)
		WD40 repeat	346..385	CDD:293791	29/38 (76%)
		WD40 repeat	393..434	CDD:293791	28/40 (70%)
		WD40 repeat	442..481	CDD:293791	20/38 (53%)
		WD40 repeat	488..529	CDD:293791	24/40 (60%)
		WD40 repeat	535..573	CDD:293791	31/37 (84%)
		WD40 repeat	581..607	CDD:293791	11/25 (44%)