DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fatp1 and Slc27a2

DIOPT Version :9

Sequence 1:	NP_001162940.3	Gene:	Fatp1 / 26067068	FlyBaseID:	FBgn0267828	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_113924.2	Gene:	Slc27a2 / 65192	RGDID:	71103	Length:	620	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	217/575 - (37%)
Similarity:	329/575 - (57%)	Gaps:	13/575 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 RHERLNYTVADVFERNVQAHPDKVAVVSETQRWTFRQVNEHANKVANVLQAQ-GYKKGDVVALLL 233
            |..|...|:..||....:..|.|..::...:..|:.||:..:|:||..|... |.::||.|||.:
  Rat    47 RQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALFM 111

  Fly   234 ENRAEYVATWLGLSKIGVITPLINTNLRGPSLLHSITVAHCSALIYGEDFLEAVTDVAKDL-PAN 297
            .|...||..||||.|:|.....:|.|:|..||||.........|:...:..|||.:|...| ...
  Rat   112 GNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPELHEAVEEVLPTLKKEG 176

  Fly   298 LTLFQFNNENNNSETEKNIPQAKNLNALLTTASYEKPNKTQVNHHDKLVYIYTSGTTGLPKAAVI 362
            :::|..:..:|.:..:..:.:...::|.....|:    :::|......|||||||||||||||.|
  Rat   177 MSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESW----RSEVTFTTPAVYIYTSGTTGLPKAATI 237

  Fly   363 SHSRYLFIAAGIHYTMGFQEEDIFYTPLPLYHTAGGIMCMGQSVLFGSTVSIRKKFSASNYFADC 427
            :|.| |:....:....|.:..|:.||.:||||:|..::.:...::.|:|.::|.|||||.::.||
  Rat   238 NHHR-LWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGLHGCIVVGATFALRSKFSASQFWDDC 301

  Fly   428 AKYNATIGQYIGEMARYILATKPSEYDQKHRVRLVFGNGLRPQIWPQFVQRFNIAKVGEFYGATE 492
            .|||||:.|||||:.||:..|.....|:.|:|::..|||||..:|.:|::||....:.|||.:||
  Rat   302 RKYNATVIQYIGELLRYLCNTPQKPNDRDHKVKIALGNGLRGDVWREFIKRFGDIHIYEFYASTE 366

  Fly   493 GNANIMNHDNTVGAIGFVSRILPKIYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGVFIGKIVK 557
            ||...||:...:||:|..:.:..|:....:|:.|.:..||:||.||.|......|.|:.|.||.:
  Rat   367 GNIGFMNYPRKIGAVGRENYLQKKVVRHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITE 431

  Fly   558 GNPSREFLGYVDEKA-SAKKIVKDVFKHGDMAFISGDLLVADEKGYLYFKDRTGDTFRWKGENVS 621
            ..|   |.||...|. :.||.::||||.||:.|.|||||:.|.:.::||.||.|||||||||||:
  Rat   432 LTP---FFGYAGGKTQTEKKKLRDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVA 493

  Fly   622 TSEVEAQVSNVAGYKDTVVYGVTIPHTEGRAGMAAIYDPER-ELDLDVFAASLAKVLPAYARPQI 685
            |:||...|..|...::..||||.:|..|||.|||:|...|. |.:.......:::.||:|:||:.
  Rat   494 TTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRF 558

  Fly   686 IRLLTKVDLTGTFKLRKVDLQKEGYDPNAIKDALYY-QTSKGRYELLTPQVYDQV 739
            :|:...:::|||||.|||.|.:||::|:.|||.||: ..::..|..:|..:|:.:
  Rat   559 LRIQDTIEITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDAEKTYVPMTEDIYNAI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp1	NP_001162940.3	PRK08279	153..746	CDD:236217	217/575 (38%)
Fatp1	NP_001162940.3	hsFATP4_like	199..712	CDD:213305	201/516 (39%)
Slc27a2	NP_113924.2	hsFATP2a_ACSVL_like	74..610	CDD:341261	209/543 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298283at2759
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850