DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp1 and acsl3b

DIOPT Version :9

Sequence 1:	NP_001162940.3	Gene:	Fatp1 / 26067068	FlyBaseID:	FBgn0267828	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001139404.1	Gene:	acsl3b / 559656	ZFINID:	ZDB-GENE-030131-492	Length:	711	Species:	Danio rerio

Alignment Length:	780	Identity:	166/780 - (21%)
Similarity:	281/780 - (36%)	Gaps:	236/780 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 VIYTLHTMGWIFAVLVALVALLLTKPGWRWFYIAGATASR-----------------DLTALWAY 161
            ::....::.|:::|:..|          .|:.::||:.::                 ...|:.:.
Zfish    11 LLQVFRSVVWVYSVITFL----------PWYLLSGASGNQARAKRVKARAINGNPAGPYRAVNSQ 65

  Fly   162 IKLLRYTKRHERLNYTVADVFE--------------RNVQAHPDKV--------AVVSETQRWTF 204
            :||.  :..||.:: |:..|||              |.:.:..|::        .|:.....|..
Zfish    66 LKLA--SLLHEGVD-TLDKVFEYAVVHFPERDCLGTRELLSEEDEIQPNGKVFKKVILGDYNWLS 127

  Fly   205 RQVNEH-ANKVANVLQAQGYKKGDVVALLLENRAEYV--ATWLGLSKIGVITPLINTNLRGPSLL 266
            .|...| |.:..:.|.|.|.|....:|:..|.|||:|  |....:....::|  :.:.|.|.::.
Zfish   128 YQDTFHLAQRFGSGLAALGQKPLCNIAIFCETRAEWVIAAQACFMYNFPLVT--LYSTLGGSAIA 190

  Fly   267 HSITVAHCSALIYGEDFLEA----------------VTDVA----KDLPANLTLFQFNNENNNSE 311
            |.:.....:.::..:|.|::                |.|..    .|||..:
Zfish   191 HGLNETEVTHIVTSKDLLQSRLKAILLEVPRLKHIIVVDTKPTSWPDLPRGI------------- 242

  Fly   312 TEKNIPQAKNLNALLTTASYEKPNKTQVNHH-----DKLVYIYTSGTTGLPKAAVISHSRYLFIA 371
                  ...|:.|:....|  ||....|:..     |..|.:||||:||:||..:||||.   |.
Zfish   243 ------MVHNMAAVQELGS--KPENIMVSRRQPVPSDIAVIMYTSGSTGIPKGVMISHSN---II 296

  Fly   372 AGI----HYTMGFQEEDIFYTPLPLYHT---AGGIMCMGQSVLFG----STVSIRKKFSASNYFA 425
            |||    .......|.|.:...|||.|.   :..::|:......|    .|::.:..........
Zfish   297 AGITGMAERIPNLDENDTYIGYLPLAHVLELSAELVCVSHGCRIGYSSPQTLADQSSKIKKGSKG 361

  Fly   426 DCAKYNATIGQYIGEMARYI---LATKPSE------------YDQK------------------H 457
            |.:....|:...:.|:...|   :.||..|            |:.|                  .
Zfish   362 DTSVLKPTLMAAVPEIMDRIYKNVMTKVEEMSSVQKTLFVLAYNYKMEQISKGYTTPLCDRLVFR 426

  Fly   458 RVRLVFGNGLRPQI-----WPQFVQRF-NI---AKVGEFYGATEGNANIMNHDNTVGAIGFVSRI 513
            :||.:.|...|..:     .....||| ||   ..||:.||.||          |.|| |.:|.:
Zfish   427 KVRSLLGGNTRVLLSGGAPLSAATQRFMNICFCCPVGQGYGLTE----------TCGA-GTISEM 480

  Fly   514 LPKIYPISIIRADPDTGEPIRDRNGLCQLCAP------NEPGVFI-------GKIVKGNPSREFL 565
                       :|..||     |.|...:|:.      .|.|.|.       |:|:.|.|:....
Zfish   481 -----------SDYSTG-----RVGAPLVCSEIMLKDWEEGGYFSTDKPNPRGEILIGGPNVTMG 529

  Fly   566 GYVDEKASAKKIVKDVFKHGDMAFISGDLLVADEKGYLYFKDRTGDTFRWK-GENVSTSEVEA-- 627
            .|.:|:.:.:...:|  |:|...|.:||:......|.|...||..|..:.: ||.||..:|||
Zfish   530 YYKNEQKNREDFFED--KNGQRWFCTGDIGEFHPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAVL 592

  Fly   628 ----QVSNVAGY---KDTVVYGVTIPHTE---GRAGMAAIYDPERELDLDVFAASLAKVLPAYAR 682
                .:.|:..|   .::.|.|..:|:.:   ..||...|.....|:   ...|.:.|
Zfish   593 KNCPLIDNICAYANSDESYVIGFVVPNQKQLTALAGQKGIRGSWEEI---CNHAEMEK------- 647

  Fly   683 PQIIRLLTKVDLTG---TFKL-RKVDLQKEGYDPNA--IKDALYYQTSKGRYELLTPQVYDQVQR 741
             :::|::|...::|   .|:: :|:.|..|.:.|..  :.||...:    |.||.| ...|.::|
Zfish   648 -EVLRIITDAAISGKLERFEIPKKICLSAEPWTPETGLVTDAFKLK----RKELKT-HYQDDIER 706

Fly 742 741
Zfish 707 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp1	NP_001162940.3	PRK08279	153..746	CDD:236217	160/741 (22%)
Fatp1	NP_001162940.3	hsFATP4_like	199..712	CDD:213305	139/623 (22%)
acsl3b	NP_001139404.1	PLN02387	43..708	CDD:215217	160/738 (22%)
acsl3b	NP_001139404.1	LC-FACS_euk	121..708	CDD:213293	148/657 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930