DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fatp1 and Slc27a4

DIOPT Version :9

Sequence 1:	NP_001162940.3	Gene:	Fatp1 / 26067068	FlyBaseID:	FBgn0267828	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001094176.1	Gene:	Slc27a4 / 311839	RGDID:	1307383	Length:	643	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	295/634 - (46%)
Similarity:	403/634 - (63%)	Gaps:	19/634 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IFAVLV----------ALVALLLTKPGWRWFYIAGATASRDLTALWAYIKLLRYTKRHERLNYTV 178
            :|:.||          :|:.|.|...|||:..:...|..||:......:|:....:|:.:...||
  Rat    12 LFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDVFGGMVLLKVKTKVRRYLQERKTV 76

  Fly   179 ADVFERNVQAHPDKVAVVSE--TQRWTFRQVNEHANKVANVLQAQGYKKGDVVALLLENRAEYVA 241
            ..:|...|:.||||.|::.|  ...|||||::::::.|||.|||:|...|:||||.:|||.|:|.
  Rat    77 PLLFASVVRRHPDKTALIFEGTNTHWTFRQLDDYSSSVANFLQARGLVSGNVVALFMENRNEFVG 141

  Fly   242 TWLGLSKIGVITPLINTNLRGPSLLHSITVAHCSALIYGEDFLEAVTDVAKDLPANLTLFQFNNE 306
            .|||::|:||...|||||||..:|.|.:..:...|||:|.:...||.::...|...||||
  Rat   142 LWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAVYEIQAILDPTLTLF----- 201

  Fly   307 NNNSETEKNIP-QAKNLNALLTTASYEKPNKTQVNHHDKLVYIYTSGTTGLPKAAVISHSRYLFI 370
            .:.|.....:| ..::|:.||..|....|:.......|||.||||||||||||||::.||||..:
  Rat   202 CSGSWEPSTVPANTEHLDPLLEDAPKHLPSIPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRM 266

  Fly   371 AAGIHYTMGFQEEDIFYTPLPLYHTAGGIMCMGQSVLFGSTVSIRKKFSASNYFADCAKYNATIG 435
            ||.::|....:.:||.|..|||||:||.|:.:||.||.|.||.||||||||.::.||.|||.||.
  Rat   267 AALVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCVLHGMTVVIRKKFSASRFWDDCIKYNCTIV 331

  Fly   436 QYIGEMARYILATKPSEYDQKHRVRLVFGNGLRPQIWPQFVQRFNIAKVGEFYGATEGNANIMNH 500
            |||||:.||:|...|.|.:.:|:||:..|||||..||..|..||:|.:|.|||||||.|.::.|.
  Rat   332 QYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFYGATECNCSLGNF 396

  Fly   501 DNTVGAIGFVSRILPKIYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGVFIGKIVKGNPSREFL 565
            |:.|||.||.||||..:|||.::|.:.||.|.||..:|:|..|.|.:||..:|:|::.:|.|.|.
  Rat   397 DSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLVGRIIQQDPLRRFD 461

  Fly   566 GYVDEKASAKKIVKDVFKHGDMAFISGDLLVADEKGYLYFKDRTGDTFRWKGENVSTSEVEAQVS 630
            ||:::.|:.|||..||||.||.|:::||:||.||.|||||:||||||||||||||||:|||..:|
  Rat   462 GYLNQGANNKKIASDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLS 526

  Fly   631 NVAGYKDTVVYGVTIPHTEGRAGMAAIYDPERELDLDVFAASLAKVLPAYARPQIIRLLTKVDLT 695
            .:....|..||||.:|..||||||||:..|....||:.||.:|.|.||.||||..:|.|.::..|
  Rat   527 RLLQMADVAVYGVEVPGAEGRAGMAAVASPTSNCDLESFAQTLKKELPLYARPIFLRFLPELHKT 591

  Fly   696 GTFKLRKVDLQKEGYDPNAIKDALYYQTSK-GRYELLTPQVYDQVQRNE 743
            ||||.:|.:|:|||:||:.:||.|:|..:: |.|..|..:.|.::|..|
  Rat   592 GTFKFQKTELRKEGFDPSVVKDPLFYLDARTGCYVALDQEAYTRIQAGE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp1	NP_001162940.3	PRK08279	153..746	CDD:236217	285/595 (48%)
Fatp1	NP_001162940.3	hsFATP4_like	199..712	CDD:213305	259/513 (50%)
Slc27a4	NP_001094176.1	PRK08279	75..643	CDD:236217	281/571 (49%)
Slc27a4	NP_001094176.1	hsFATP4_like	99..608	CDD:213305	259/513 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342902
Domainoid	1	1.000	423	1.000	Domainoid score	I602
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1028
OMA	1	1.010	-	-		QHG63225
OrthoDB	1	1.010	-	-		D298283at2759
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	1	1.000	-	-		mtm9119
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910