DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp1 and ACSL1

DIOPT Version :9

Sequence 1:	NP_001162940.3	Gene:	Fatp1 / 26067068	FlyBaseID:	FBgn0267828	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001273637.1	Gene:	ACSL1 / 2180	HGNCID:	3569	Length:	698	Species:	Homo sapiens

Alignment Length:	775	Identity:	173/775 - (22%)
Similarity:	268/775 - (34%)	Gaps:	212/775 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SHDRQRRRRQRFLVIFRFFCATVAFGLAIACVIYTLHTMGW-IFAVLVALVALLLTKP------- 139
            :|:..|..|...||.||.:..|:.          |...||: .||.|.........||
Human     3 AHELFRYFRMPELVDFRQYVRTLP----------TNTLMGFGAFAALTTFWYATRPKPLKPPCDL 57

  Fly   140 GWRWFYIAGATASRDLTALWAYIKLLRYTKRHERLNYTVADV------FERNVQA---------- 188
            ..:...:||:..:|....|          ...|.|.|...||      |:|.:|.
Human    58 SMQSVEVAGSGGARRSALL----------DSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSR 112

  Fly   189 HPDKVAVVSETQRW-TFRQVNEHANKVANVLQAQGYKKG--DVVALLLENRAEYVATWLGLSKIG 250
            .||      :...| :::||.|.:..:.:.|..:|:|..  ..:.:..:||.|:|....|.....
Human   113 KPD------QPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYS 171

  Fly   251 -VITPLINTNLRGPSLLHSITVAHCSALIYGEDFLEAVTDVAKDLPANLTLFQFNNENNNSETEK 314
             ||.||.:| |...::.:.:..|..|.             |..|.|....|.....||      |
Human   172 MVIVPLYDT-LGNEAITYIVNKAELSL-------------VFVDKPEKAKLLLEGVEN------K 216

  Fly   315 NIPQAK------------------------NLNAL--LTTASYEKPNKTQVNHHDKLVYIYTSGT 353
            .||..|                        ::.|:  |..|:..||....  ..|..|..:||||
Human   217 LIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPA--PEDLAVICFTSGT 279

  Fly   354 TGLPKAAVISHSRYL-----FIAAGIHYTMGFQEEDIFYTPLPLYHTAGGI-----MCMGQSV-L 407
            ||.||.|:::|...:     |:.| ...|:....:|...:.|||.|....:     :|.|..: .
Human   280 TGNPKGAMVTHRNIVSDCSAFVKA-TENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGF 343

  Fly   408 FGSTVSIRK---KFSASNYFADCAK-----YNATIGQYIGEMARYIL--ATKPSEYDQK------ 456
            |...:.:..   |......|....:     ::...||....:.|::|  |:|..|.:.:
Human   344 FQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRN 408

  Fly   457 ---------HRVRLVFGNGLRPQIW-----PQFVQRFNIAKVG----EFYGATEGNAN---IMNH 500
                     |:|:...|..:|..:.     ...|..|..|.:|    |.||.||..|.   .|..
Human   409 NSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPG 473

  Fly   501 DNTVGAIGFVSRILPKIYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGVFIGKI-VKGNPSREF 564
            |.|.|.:|     .|  .|.::|:        :.|...:..:.|..|     |:: |||  ...|
Human   474 DWTAGHVG-----AP--MPCNLIK--------LVDVEEMNYMAAEGE-----GEVCVKG--PNVF 516

  Fly   565 LGYVDEKA-SAKKIVKDVFKH-GDMA--FISGDLLVADEKGYLYFKDRTGDTFR-WKGENV-STS 623
            .||:.:.| :|:.:.||.:.| ||:.  ..:|.|.:.|.|.:: ||...|:... .|.||: ..|
Human   517 QGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHI-FKLAQGEYIAPEKIENIYMRS 580

  Fly   624 EVEAQVSNVAGYKDTVVYGVTIPHTEGRAGMA--------------------AIYDPERELDLDV 668
            |..|||..........:..:.:|..|.....|                    ||.:....|..|.
Human   581 EPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDS 645

  Fly   669 FAASLAKVLPAYARPQIIRLLTKVD---LTGTFKLRKVDLQKEGYDPNAIKDALYYQTSK 725
            ......:|......|:    |..:|   ||.|.|.::.:|:  .|..:.|.|  .|.|.|
Human   646 GLKPFEQVKGITLHPE----LFSIDNGLLTPTMKAKRPELR--NYFRSQIDD--LYSTIK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp1	NP_001162940.3	PRK08279	153..746	CDD:236217	155/697 (22%)
Fatp1	NP_001162940.3	hsFATP4_like	199..712	CDD:213305	138/620 (22%)
ACSL1	NP_001273637.1	LC-FACS_euk	116..694	CDD:341250	140/631 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930