DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp1 and SLC27A3

DIOPT Version :9

Sequence 1:	NP_001162940.3	Gene:	Fatp1 / 26067068	FlyBaseID:	FBgn0267828	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_077306.3	Gene:	SLC27A3 / 11000	HGNCID:	10997	Length:	683	Species:	Homo sapiens

Alignment Length:	719	Identity:	243/719 - (33%)
Similarity:	348/719 - (48%)	Gaps:	129/719 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LAIACVIYTLH---TMGWIFAVLVALVALLLTKPGWRWFYIAGATASRD-----LTALWAYIKLL 165
            |.:..::..||   .:.|:.|.|...|..|..|...|...:|.|.|..:     .:..|...:|.
Human    11 LLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEGPEGGCSLAWRLAELA 75

  Fly   166 RYTKRHERLNYTVADVFERNVQAHPDKVAVVSETQRWTFRQVNEHANKVANV-LQAQGY------ 223
            :....|..|                     :..::|:::.:....:|:.|.. |:|.|:
Human    76 QQRAAHTFL---------------------IHGSRRFSYSEAERESNRAARAFLRALGWDWGPDG 119

  Fly   224 ---------------------------------------------KKGDVVALLLENRAEYVATW 243
                                                         ..|..|||||....|::..|
Human   120 GDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEFLWLW 184

  Fly   244 LGLSKIGVITPLINTNLRGPSLLHSITVAHCSALIYGEDFLEAVTDVAKDLPA----NLTLFQFN 304
            .||:|.|:.|..:.|.||...|||.:......||:...:|||:   :..||||    .|.|:...
Human   185 FGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLES---LEPDLPALRAMGLHLWAAG 246

  Fly   305 NENNNSETEKNIPQAKNLNALLTTASYE----------KPNKTQVNHHDKLVYIYTSGTTGLPKA 359
            ...:.:          .::.||...|.|          .|....    |..:||:||||||||||
Human   247 PGTHPA----------GISDLLAEVSAEVDGPVPGYLSSPQSIT----DTCLYIFTSGTTGLPKA 297

  Fly   360 AVISHSRYLFIAAGIHYTMGFQEEDIFYTPLPLYHTAGGIM----CMGQSVLFGSTVSIRKKFSA 420
            |.|||.:.| ...|.:...|..:||:.|..|||||.:|.::    |||    .|:||.::.||||
Human   298 ARISHLKIL-QCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMG----IGATVVLKSKFSA 357

  Fly   421 SNYFADCAKYNATIGQYIGEMARYILATKPSEYDQKHRVRLVFGNGLRPQIWPQFVQRFNIAKVG 485
            ..::.||.::..|:.|||||:.||::...||:.::.|:|||..|:||||..|.:||:||...:|.
Human   358 GQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVL 422

  Fly   486 EFYGATEGNANIMNHDNTVGAIGFVSRILPKIYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGV 550
            |.||.||||...:|:....||:|..|.:...|:|.|:||.|..|||||||..|.|...:|.|||:
Human   423 ETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGL 487

  Fly   551 FIGKIVKGNPSREFLGYVDEKASAK-KIVKDVFKHGDMAFISGDLLVADEKGYLYFKDRTGDTFR 614
            .:..:.:.:|   ||||......|: |::||||:.||:.|.:|||||.|::|:|.|.||||||||
Human   488 LVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFR 549

  Fly   615 WKGENVSTSEVEAQVSNVAGYKDTV-VYGVTIPHTEGRAGMAA-IYDPERELDLDVFAASLAKVL 677
            ||||||:|:|| |:|.....:...| |||||:|..|||||||| :..|...|||......:::.|
Human   550 WKGENVATTEV-AEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENL 613

  Fly   678 PAYARPQIIRLLTKVDLTGTFKLRKVDLQKEGYDPNAIKDALY-YQTSKGRYELLTPQVYDQVQR 741
            |.||||:.:||...:..|.|||.:||.:..||:||:.:.|.|| ...:.|.|..||...|..:..
Human   614 PPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLA 678

  Fly   742 NEIR 745
            ..:|
Human   679 GNLR 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp1	NP_001162940.3	PRK08279	153..746	CDD:236217	230/672 (34%)
Fatp1	NP_001162940.3	hsFATP4_like	199..712	CDD:213305	215/585 (37%)
SLC27A3	NP_077306.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..145		0/25 (0%)
SLC27A3	NP_077306.3	hsFATP2a_ACSVL_like	163..673	CDD:213304	218/535 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298283at2759
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950