Protein Alignment Tmc and TMC7

DIOPT Version :10

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: NP_001287661.1
• Gene: TMC7 / 79905
• HGNCID: 23000
• Length: 758
• Species: Homo sapiens
• Alignment Length: 1339
• Identity: 211/1339 - (15%)
• Similarity: 358/1339 - (26%)
• Gaps: 689/1339 - (51%)

  Fly   206 SSRRASSPMDHVLD-----SVERRRSSVYTTSSEEGTNQEST-------QEQIFENIRLHKEVIQ 258
            ||..:|.|::.:.:     |:.|||::|::...:.||..:.|       :::|.||:..|
Human    29 SSCFSSPPVNFLQELPSYRSIARRRTTVHSRDKQSGTLLKPTDSYSSQLEDRIAENLSSH----- 88

  Fly   259 SVKLQPWPIRKKLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARWRHWKRETASF 323
            |::.....|.:|.:|            ..:||......|..|.|.|:.   :..|:.:..:....
Human    89 SLRNYALNISEKRRL------------RDIQETQMKYLSEWDQWKRYS---SKSWKRFLEKAREM 138

  Fly   324 LTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETD---- 384
            .|.|..|...|:.||..||:|:.|||:|||:|:.:|::|.:.:...|:.| ...||:..|:
Human   139 TTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLP-VLLTKYKITNSSFV 202

  Fly   385 --PRKRMSDPEARV----AGNLFTFWEF-------EGYLKYSPMFYGYYSSTSGISTSG--YKLP 434
              |.|.| |.:..|    :..|..|:.:       .|:|:.:.:|||:| :..|:....  |.||
Human   203 LIPFKDM-DKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHY-TIDGVKFQNFTYDLP 265

  Fly   435 LAYFLTAVLVYIYSFVATLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASV 499
            |||.|:.:.....|.:..:::..|..:.:.:.|::....:..|:|.||||.|.:...|..:.:|:
Human   266 LAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSL 330

  Fly   500 VVGFKEALLEEAEKKK-----DNRNWRVILQRILVNILVMGLLGLS-GATVVLLVNHSEDLAKH- 557
            ....:..|.||..::|     .....|:...|:.:|.:|:.:||.. .|..|..|...|.:.|.
Human   331 RYELRADLEEERMRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEI 395

  Fly   558 ------DNWLSRNAVNVTMTLLSFFLPMIFEALGLFENWHPRQQLRLQLARIMILNMLNLYSLMF 616
                  :|.......::.:||.:|..||||..:..:|::.|..::||.:.|.:.:.:..:..|:|
Human   396 DKMVFGENLFILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVF 460

  Fly   617 SFIYKINSKEKPLQMLKLENETNTMELKNLLSSIEALRAMTPTTSLYGESTSDGLFDDSTSTATW 681
            :...||.|                                               .||.|
Human   461 TLGSKITS-----------------------------------------------CDDDT----- 473

  Fly   682 GEDGGGLFSTTAAAALISTTVQRLKCYNMTVKCSKLRRNIISGKHLATTLMVLNLTTPAMVPPTL 746
                                            |
Human   474 --------------------------------C-------------------------------- 474

  Fly   747 PTTLPTTFPTTLPTTLPTTLPTALPTTLPTTLPTTLPSTLATTTATTSSIWSTTEETSPTTTTTS 811
                                                                             
Human   475 ----------------------------------------------------------------- 474

  Fly   812 PWTTLPPSTTTTEATTTTERATTTTEATSTTTLKITTAEINSTLSDTTKPLGKSIDTEIPNSTTN 876
                                                                             
Human   475 ----------------------------------------------------------------- 474

  Fly   877 SATLSTIPATLNTTNLPLNSTTKLTTTTSTEKPQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNS 941
                                                                             
Human   475 ----------------------------------------------------------------- 474

  Fly   942 YSDITDYSSEPSEIEDFDEQESTDQADDPLAKVLEQLDENETKGRRKRALAESPFFTSKYSRRHR 1006
              |:..|:.
Human   475 --DLCGYNQ-------------------------------------------------------- 481

  Fly  1007 NESAVSAGQPRETTESVNATPSRWPFNWASFRQTTPRTTTTRRVPSGILTKEEWERLRRLRGRIT 1071
                                                                             
Human   482 ----------------------------------------------------------------- 481

  Fly  1072 TTTSTSTTSTTTRRPRWRYRTTTTELTSTTEEESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEY 1136
                                                                             
Human   482 ----------------------------------------------------------------- 481

  Fly  1137 TTTEGSENRPYYVGYVDISEMGSTIYYDGDSEFLEECVITICPKGDDFFGSTTESPDSTTQSSDS 1201
                                                                             
Human   482 ----------------------------------------------------------------- 481

  Fly  1202 KQLTTVKLTPLERKQKRLKEVQLAIKQIQTNLTTMCWETSLGQELSKVIVFDGLMSIVAPLCIDF 1266
                  ||.|                         ||||.:|||:.|:::||.::.:...|.:||
Human   482 ------KLYP-------------------------CWETQVGQEMYKLMIFDFIIILAVTLFVDF 515

  Fly  1267 LRALFVRYVNQ---NWCWDMEKTFPQYGDFKIAENILTLINNQGQVWMGIFFSPGLVLINLVKLM 1328
            .|.|.|.|.:.   ..||..:       :|.|.:|:|.::..|...|:|.||||.|..|..:|.:
Human   516 PRKLLVTYCSSCKLIQCWGQQ-------EFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFI 573

  Fly  1329 IMMYFRSWIVL-TCNVPHEVVFKASKSNNFYLSLLLTMLFLCVLPVGYAIVWLRPSWHCGPFSEY 1392
            |:.|.:.|.:| ||. |....|:||.||.|:|.:||..|.|.::|:..:|..:..|..||||:.:
Human   574 IIFYVKEWSLLYTCR-PSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNF 637

  Fly  1393 NRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLLLLLILIIYYLVSLTGALREANQDLRTQLQ 1457
            |...|.|..|. :..|..|...:..:||.:..:|..:::.||::|.::|.||.:.....||.||.
Human   638 NTTWEVIPKTV-STFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLS 701

  Fly  1458 KEREEE--------------RKKIFKVPEVKQAEPTATT 1482
            ..|:..              ||.:|....||..:|:.||
Human   702 LVRKHSSRGSWLGTFTQDTARKVLFSWEGVKLLQPSLTT 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1237..1352	CDD:462275	41/118 (35%)
TMC7	NP_001287661.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..71		6/19 (32%)
		TMC	486..597	CDD:462275	41/118 (35%)