Protein Alignment Tmc and TMC5

DIOPT Version :10

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: NP_001098718.1
• Gene: TMC5 / 79838
• HGNCID: 22999
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 144/705 - (20%)
• Similarity: 253/705 - (35%)
• Gaps: 175/705 - (24%)

  Fly    11 AGTSGLSNGESLRSPPAPAPRRPKPGILRLDIGKPRRSSGGSVDF-------RCVGSSSSNGNTS 68
            :||...:...:.|:.|......|:|...........|:|....|:       ...|||||    .
Human    84 SGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSS----G 144

  Fly    69 NVATGANSENNSGVTSPHQLSVTWAPPCDLDRGGWQMQSSADAKREFYKGQRGRRAASQEDHRSY 133
            |.|......::.|...|             |..|.|..|.....|........|:   ..:|.|:
Human   145 NYAGSRTHPDHFGSLEP-------------DYPGAQSNSDHPGPRANLNHPGSRK---NLEHTSF 193

  Fly   134 ELN---------------------------DFPLQNQSSDAESCHQEPHFAHQRSPGIGFDEDGG 171
            .:|                           |:|....:.:..|..:||.::...:
Human   194 RINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWREPDYSDAEN---------- 248

  Fly   172 GGDIDDEESYTISVSAIMQRRASVR-GYRGKRGSRSSRRASSPMDHV-----------LDSVERR 224
            |.|....|:..:: ..::.|.:|:: .:|        .|:..|:..:           :.|:|..
Human   249 GHDYGSSETPKMT-RGVLSRTSSIQPSFR--------HRSDDPVGSLWGENDYPEGIEMASMEMA 304

  Fly   225 RSSVYTTSSEEGTNQ-------ESTQEQIFENIRL-----HK-----EVIQSVKLQPWPIRKKLK 272
            .|..::.....|:..       ||.....:.|..|     ||     ::|.|  |.|...|.::|
Human   305 NSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIAS--LIPMTSRDRIK 367

  Fly   273 LVR-QAKTYVARHEGALQERFAMSRSTRDLWARFKILMAAR-----------------WRHWKRE 319
            .:| |.:|        ::|:    |:.|.:..:.|.....|                 :|..|..
Human   368 AIRNQPRT--------MEEK----RNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNS 420

  Fly   320 TASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETD 384
            .:..|..:..|:..:|.|...||:.|.|||.|||||:..||...|...:|:|.|::...|.....
Human   421 LSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQ 485

  Fly   385 PRKRMSDPEARVAGNLFTFWEF---EGYLKYSPMFYGYYSSTS---GISTSGYKLPLAYFLTAVL 443
                            ||..||   .||.:.:.|:||:|::::   |.|.:.|.:.|||..|...
Human   486 ----------------FTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGA 534

  Fly   444 VYIYSFVATLRKMAENSRNSKLSSKDDECVFS---WKLFTGWDFMIGHAETAHNRIASVVVGFKE 505
            .....|.:.|..||:..||:.::..    ::|   .||...|||.:.|.:....:..::....:|
Human   535 CLTTCFFSLLFSMAKYFRNNFINPH----IYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRE 595

  Fly   506 ALLEEAEKKKDNRNWRVILQR----ILVNILVMGLLGLSGATVVLLVNHS-EDLAKHDNWLSRNA 565
            . |.|..::.....:..:|.|    ::..::..|:.....|.|..|..:: |.|..|.|..:...
Human   596 N-LSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLL 659

  Fly   566 VNVTMTLLSFFLPMIFEALGLFENWH-PRQQLRLQLAR-----IMILNMLNLYSL 614
            :...::.::..:|.|:....|.|.:. ||.::.:.|.|     |.|:.:|..|.|
Human   660 LPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWL 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1237..1352	CDD:462275
TMC5	NP_001098718.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..289		40/243 (16%)
		PHA03307	36..>293	CDD:223039	40/247 (16%)
		TMC	724..830	CDD:462275