DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmc and TMC5

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	NP_001098718.1	Gene:	TMC5 / 79838	HGNCID:	22999	Length:	1006	Species:	Homo sapiens

Alignment Length:	705	Identity:	144/705 - (20%)
Similarity:	253/705 - (35%)	Gaps:	175/705 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGTSGLSNGESLRSPPAPAPRRPKPGILRLDIGKPRRSSGGSVDF-------RCVGSSSSNGNTS 68
            :||...:...:.|:.|......|:|...........|:|....|:       ...|||||    .
Human    84 SGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSS----G 144

  Fly    69 NVATGANSENNSGVTSPHQLSVTWAPPCDLDRGGWQMQSSADAKREFYKGQRGRRAASQEDHRSY 133
            |.|......::.|...|             |..|.|..|.....|........|:   ..:|.|:
Human   145 NYAGSRTHPDHFGSLEP-------------DYPGAQSNSDHPGPRANLNHPGSRK---NLEHTSF 193

  Fly   134 ELN---------------------------DFPLQNQSSDAESCHQEPHFAHQRSPGIGFDEDGG 171
            .:|                           |:|....:.:..|..:||.::...:
Human   194 RINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWREPDYSDAEN---------- 248

  Fly   172 GGDIDDEESYTISVSAIMQRRASVR-GYRGKRGSRSSRRASSPMDHV-----------LDSVERR 224
            |.|....|:..:: ..::.|.:|:: .:|        .|:..|:..:           :.|:|..
Human   249 GHDYGSSETPKMT-RGVLSRTSSIQPSFR--------HRSDDPVGSLWGENDYPEGIEMASMEMA 304

  Fly   225 RSSVYTTSSEEGTNQ-------ESTQEQIFENIRL-----HK-----EVIQSVKLQPWPIRKKLK 272
            .|..::.....|:..       ||.....:.|..|     ||     ::|.|  |.|...|.::|
Human   305 NSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIAS--LIPMTSRDRIK 367

  Fly   273 LVR-QAKTYVARHEGALQERFAMSRSTRDLWARFKILMAAR-----------------WRHWKRE 319
            .:| |.:|        ::|:    |:.|.:..:.|.....|                 :|..|..
Human   368 AIRNQPRT--------MEEK----RNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNS 420

  Fly   320 TASFLTVLIPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETD 384
            .:..|..:..|:..:|.|...||:.|.|||.|||||:..||...|...:|:|.|::...|.....
Human   421 LSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQ 485

  Fly   385 PRKRMSDPEARVAGNLFTFWEF---EGYLKYSPMFYGYYSSTS---GISTSGYKLPLAYFLTAVL 443
                            ||..||   .||.:.:.|:||:|::::   |.|.:.|.:.|||..|...
Human   486 ----------------FTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGA 534

  Fly   444 VYIYSFVATLRKMAENSRNSKLSSKDDECVFS---WKLFTGWDFMIGHAETAHNRIASVVVGFKE 505
            .....|.:.|..||:..||:.::..    ::|   .||...|||.:.|.:....:..::....:|
Human   535 CLTTCFFSLLFSMAKYFRNNFINPH----IYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRE 595

  Fly   506 ALLEEAEKKKDNRNWRVILQR----ILVNILVMGLLGLSGATVVLLVNHS-EDLAKHDNWLSRNA 565
            . |.|..::.....:..:|.|    ::..::..|:.....|.|..|..:: |.|..|.|..:...
Human   596 N-LSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLL 659

  Fly   566 VNVTMTLLSFFLPMIFEALGLFENWH-PRQQLRLQLAR-----IMILNMLNLYSL 614
            :...::.::..:|.|:....|.|.:. ||.::.:.|.|     |.|:.:|..|.|
Human   660 LPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWL 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585
TMC5	NP_001098718.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..289		40/243 (16%)
TMC5	NP_001098718.1	TMC	729..825	CDD:285101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840