DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmc and Tmc5

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	NP_001098722.1	Gene:	Tmc5 / 74424	MGIID:	1921674	Length:	967	Species:	Mus musculus

Alignment Length:	753	Identity:	161/753 - (21%)
Similarity:	275/753 - (36%)	Gaps:	195/753 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEPAAAAGTSGLSNG--ESLRSPPAPAPRRPKP---GILRLDIGKPRRSS-----------GGSV 53
            |||..   ...|||.  :..||.|..|..|.:|   ..:..|....|..|           .||.
Mouse    70 EEPDY---PGSLSNTVYQDTRSHPFSAHSRTRPDYESSIEPDYNDFRSESYHAGLPMEPDYPGSQ 131

  Fly    54 D---FRCVGSSSSN--GNTSNVA----------TGA--NSENNSGVTSPHQLSVTWAPPCDLDRG 101
            .   |..||.||.|  |..:|:.          .||  ||..:|| :.||    :..|....|.|
Mouse   132 SHPGFAGVGRSSMNYTGPRTNLGYLGSLEEPDYPGAQDNSYYHSG-SRPH----SNLPGSRRDAG 191

  Fly   102 GWQMQSSADAKREFYKGQRGRRAASQEDHRSYELNDFPLQNQSSDAESCHQEPH----FAHQRSP 162
                          |.|.|              :|.:|......|......:|:    :.....|
Mouse   192 --------------YAGSR--------------INSYPDDLGEPDYPGAENQPNSPRFYGKPDYP 228

  Fly   163 GIGFDEDGGGGDIDDEESYTISVS-AIMQRRASVRGYRGKR--------GSRSSRRASSPMDHVL 218
            |.   |:|.|        |:.|.| |:::|.....|..|:|        |..|...|..|.:..:
Mouse   229 GA---EEGDG--------YSSSKSLAVIRRGNGPFGMLGRRNEDYPEGIGMVSMEMAGDPRNGYV 282

  Fly   219 DSVERRRSS-------VYTTSSEEGTNQESTQEQIFENIRL-HKEVIQSVKLQPWPIRKKLKLVR 275
            :....||.|       :...:.:..|:.:. |:.|...|.: .::.|::::.||..:::|.:|.:
Mouse   283 NPAYTRRISPVCPDRNLLLCAHDWHTSVQG-QKLIASLIPMTTRDRIKTIRNQPRTMQEKRELRK 346

  Fly   276 QAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRIKEIESH 340
            .......:....:.|....::....|...::     |.|:...|..:::|:   |:.|.|.|...
Mouse   347 IVDKEKNKQSHGILEANCCAQCLGSLSLTYR-----RTRNGLSELLNYITL---WQKRFKVIGGK 403

  Fly   341 FGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDPEARVAGNLFTFWE 405
            ||:.|.|||:|||||:..||...:...:|:|.|::.........                ||..|
Mouse   404 FGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTVGAKNTLQ----------------FTGLE 452

  Fly   406 F---EGYLKYSPMFYGYYSSTS---GISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAENSRNSK 464
            |   .||...:.|:||:|::::   .:..:.|.:.|||..|.....:..|.:.|..||:..||:.
Mouse   453 FFTGAGYFGDTVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVVCFFSLLFSMAKYFRNNF 517

  Fly   465 LSSKDDECVFS---WKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRVILQR 526
            ::..    ::|   .||...|||.:.|.:....:..::....:|.|.|..::     |:|:...:
Mouse   518 INPH----IYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQE-----NYRLTFNQ 573

  Fly   527 ILVNIL--VMGLLGLSGATVVLLV-------NHSEDLAKHDNWLSRNAVNVTMTLLSFFLPMIFE 582
            .|....  |...|..:|.|....|       .:||.|..|.|..:...:...::.::..:|..:.
Mouse   574 QLTRFSAHVAAWLVSTGVTAACCVAVYYLAEYNSEFLKTHRNPGAVLLLPFVVSCINLAVPRFYS 638

  Fly   583 ALGLFENWH-PRQQLRLQLARIMILNM----------LNLYS------------------LMFSF 618
            ...|.|.:. |||::.:.|.|.:.|.:          ||:.:                  |:..|
Mouse   639 MFRLVERYEIPRQEVYVLLVRNIFLKISIVGILCYYWLNIVALSGEECWETLIGQDIYRLLLMDF 703

  Fly   619 IYK-------------INSKEKPLQMLKLENETNTMEL 643
            ::.             |..|...|.:.:.:...|.:||
Mouse   704 VFSLADSLLGEFLRRLIGMKFTSLSLQEFDIARNVLEL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585
Tmc5	NP_001098722.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..240		49/216 (23%)
Tmc5	NP_001098722.1	TMC	686..791	CDD:369533	8/56 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840