DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmc and tmc5

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	XP_005163977.1	Gene:	tmc5 / 561497	ZFINID:	ZDB-GENE-120411-6	Length:	685	Species:	Danio rerio

Alignment Length:	451	Identity:	100/451 - (22%)
Similarity:	183/451 - (40%)	Gaps:	100/451 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 RRSSVY----TTSSEEGTNQESTQEQIFENIRLHKEVI------------QSVKLQPW------P 266
            ||.|||    |.....|......|:::..|.   .|::            |:::..|.      .
Zfish     2 RRMSVYPQHGTALENLGLTAHEIQQEVENNT---SELVSDLSDLSAGARFQAIRSLPMSYNERKA 63

  Fly   267 IRKKLKLVRQAKTYV---ARHEGALQERFAMSRSTRDLWARFKI-LMAARWRHWKRETASFLTVL 327
            ||.::..::.:||.:   .|.:.:|..|            ||:. |.:||.|            |
Zfish    64 IRNRVNNIKLSKTILPTDCRQQVSLSFR------------RFRASLTSARQR------------L 104

  Fly   328 IPWELRIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDP 392
            :.|:..:|||...||:.|.|||.||:||:..|:...:....|:..|:.             :..|
Zfish   105 VVWQDTLKEIGGRFGTSVLSYFLFLKWLLKFNVFSFVINFCFITIPQI-------------VHAP 156

  Fly   393 E-ARVAGNLFTFWEFE-----GYLKYSPMFYGYYSSTSGISTSGYKLPLAYFLTAVLVYIYSFVA 451
            . :.|.|    |...|     ||...:.:|||.|.....:|...|.:.||||.|.....:...::
Zfish   157 NISHVTG----FRGLELLTGVGYFNQTVLFYGGYDGEVIVSKPAYNMQLAYFFTIAAYMVLCGLS 217

  Fly   452 TLRKMAENSRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAE-KKK 515
            .:..|:.:.:.:.:.........:|:|...|||.:.:.:.......::.:..||:|.|..: |.|
Zfish   218 LIYSMSRSFQKNFVLETGPVSGGAWRLLCSWDFSVVNEKAIQYNKNNLGIQLKESLSERLQMKNK 282

  Fly   516 DNRNWRV------ILQRILVNILVMGLLGLSGATVVLLVNHS---------EDLAKHDNWLSRNA 565
            .:.:.|:      ::..:|..:|.:|    |||.:..|....         .||....:.|   .
Zfish   283 ISLSDRIKHLSLNLVAWLLCLLLALG----SGAGIYFLGTEQLTFSFNQDPNDLVSEASTL---L 340

  Fly   566 VNVTMTLLSFFLPMIFEALGLFENW-HPRQQLRLQLARIMILNMLNLYSLMFSFIYKINSK 625
            :.|.::|::..:|:::..:|..|.: :||.::.:.:||.:||.|..|..|.|.::..:..|
Zfish   341 LPVVVSLINLIVPLLYSLIGKMETYSNPRAKIYISIARNIILKMSLLGILCFYWLNFVPDK 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585
tmc5	XP_005163977.1	TMC	409..504	CDD:285101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840