DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tmc and Tmc5

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	XP_038941138.1	Gene:	Tmc5 / 365360	RGDID:	1307037	Length:	965	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	126/562 - (22%)
Similarity:	221/562 - (39%)	Gaps:	101/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DAKREFYKGQRG----------------RRAASQEDHRSYELNDFPLQNQSSDAESCHQEPHFAH 158
            |.:...|.|.:|                ||.|.....|   :|.:|......|......:|:
  Rat   156 DLEEPDYPGAQGNSYHSGPRSHSNLPGSRRNAGYAGSR---INSYPDSLGEPDYPGAENQPN--- 214

  Fly   159 QRSPGIGFDEDGGGGDIDDEESYTISVSAIMQRRASVRGYRGKRGS--------RSSRRASSPMD 215
              ||......|..|.:..|..|.:.::..|.:.|.|. |..|:...        .|...|..|.:
  Rat   215 --SPDFYGKPDYPGAEEGDVYSPSKTLGVIGRSRGSF-GILGREDGDYPEGIEMASLGMAGDPRN 276

  Fly   216 HVLDSVERRRSS-------VYTTSSEEGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRKKLKL 273
            ..::....|.||       :...:.:..|:.:.            :::|.|  |.|...|.::|.
  Rat   277 GYVNPAYMRGSSPVCPDRNLLLCARDWNTSPQG------------QKLIAS--LVPMTSRDRIKT 327

  Fly   274 VR-QAKTYVARHEGAL---QERFAMSRST--RDLWARFKILMAARWRHWKRETASFLTVLIPWEL 332
            :| |.:|...:.|...   :|:...|..|  .:..|:....::..:|..|...:..|..:..|:.
  Rat   328 IRNQPRTMQEKRELRKIVDKEKNKQSHGTFEANCCAQCLSSLSLAYRRTKSSLSELLNYISLWQK 392

  Fly   333 RIKEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEYFATKHGETDPRKRMSDPEARVA 397
            |.|.|...||:.|.|||:|||||:..||...:...:|:|.|::..   ||.:..:
  Rat   393 RFKVIGGKFGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTV---GEKNTLQ---------- 444

  Fly   398 GNLFTFWEF---EGYLKYSPMFYGYYSSTS---GISTSGYKLPLAYFLTAVLVYIYSFVATLRKM 456
               ||..||   .||.:.:.|:||:|::::   .:..:.|.:.|||..|.....:..|.:.|..|
  Rat   445 ---FTGLEFFTGAGYFRETVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVICFFSLLFSM 506

  Fly   457 AENSRNSKLSSKDDECVFS---WKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNR 518
            |:..||:.::..    ::|   .||...|||.:.|.:....:..::....:|. |.|..::.|..
  Rat   507 AKYFRNNFINPH----IYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIREN-LSEIRQENDRL 566

  Fly   519 NWRVILQRILVNILV-MGLLGLSGATVV----LLVNHSEDLAKHDNWLSRNAVNVTMTLLSFFLP 578
            .....|.|..|::.. :...|::.|..|    |...:||.|..|.|..:...:...::.::..:|
  Rat   567 TLNQKLTRFSVHVAAWLVSTGITAACCVAVYYLAEYNSEFLKTHKNPGAVLLLPFVVSCINLAVP 631

  Fly   579 MIFEALGLFENWH-PRQQLRLQLAR-----IMILNMLNLYSL 614
            ..:....|.|.:. |||::.:.|.|     |.|:.:|..|.|
  Rat   632 RFYSMFRLVERYEIPRQEVYVLLIRNIFLKISIVGILCYYWL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585
Tmc5	XP_038941138.1	TMC	683..789	CDD:400250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353133
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840