DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tmc and Tmc4

DIOPT Version :9

Sequence 1:	NP_001303362.1	Gene:	Tmc / 26067066	FlyBaseID:	FBgn0267796	Length:	2036	Species:	Drosophila melanogaster
Sequence 2:	NP_001029276.1	Gene:	Tmc4 / 308310	RGDID:	1304811	Length:	698	Species:	Rattus norvegicus

Alignment Length:	236	Identity:	73/236 - (30%)
Similarity:	120/236 - (50%)	Gaps:	17/236 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1237 CWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAENILT 1301
            ||||.||||:.|:::||.||.::..|.|.|.|.:..     ..|...........:|::.:.:|.
  Rat   461 CWETRLGQEMYKLVLFDLLMGLLVTLLIQFPRKILC-----GLCPGALGRLSGTLEFQVPDEVLG 520

  Fly  1302 LINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLLTML 1366
            ||..|..||:|.||.|.|.|||..|.:|:.:.:...:.:...|....|:||.:|.|:..:||..|
  Rat   521 LIYAQTVVWVGSFFCPLLPLINTAKFLILFWLKKITLFSIYSPASRTFRASTANFFFPLVLLVGL 585

  Fly  1367 FLCVLPVGYAIVWLRPSWHCGPF----SEYNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPL 1427
            .:..:||.|:|..:.||..||||    |.:.:|.|.|     .:||:.....|.:|.:.:..:||
  Rat   586 AISAVPVLYSIFLIPPSKLCGPFQGKLSIWAQIPESI-----ESLPQTAQNFLYFLGTQAFTVPL 645

  Fly  1428 LLLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKKIF 1468
            |::..:::.|.|:|.........:|:.|::   .|.:.|:|
  Rat   646 LIVSSILMMYTVALANCYGRLISELKRQIE---TEVQNKVF 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1242..1348	CDD:285101	32/105 (30%)
Tmc	NP_001303362.1	DUF612	<1447..1844	CDD:282585	5/22 (23%)
Tmc4	NP_001029276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..104
		RSN1_7TM	<371..>439	CDD:280815
		TMC	466..566	CDD:285101	32/104 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910