Protein Alignment Tmc and Tmc3

DIOPT Version :10

• Sequence 1: NP_001303362.1
• Gene: Tmc / 26067066
• FlyBaseID: FBgn0267796
• Length: 2036
• Species: Drosophila melanogaster
• Sequence 2: NP_808363.3
• Gene: Tmc3 / 233424
• MGIID: 2669033
• Length: 1130
• Species: Mus musculus
• Alignment Length: 1732
• Identity: 416/1732 - (24%)
• Similarity: 630/1732 - (36%)
• Gaps: 690/1732 - (39%)

  Fly   205 RSSRRASSPMDHVLDSVERRRSSVYTTSSEEGTNQESTQEQIFENIRLHKEVIQSVKLQPWPIRK 269
            ||.||.:|......||:....|.....:.|  |...|..||||:||:..|:::.:::.:||.:.:
Mouse    11 RSIRRNASQCYLYQDSLLLGNSDDSFNADE--TGDSSDPEQIFQNIQFQKDLMANIRCRPWTMGQ 73

  Fly   270 KLKLVRQAKTYVARHEGALQERFAMSRSTRDLWARFKILMAARWRHWKRETASFLTVLIPWELRI 334
            ||:.:|:||..|.:.||.|........:..:||.:|           .|...:|:.:.||||:||
Mouse    74 KLRALRRAKEIVLKFEGRLTRTRGYQAAGAELWRKF-----------ARLACNFVVIFIPWEMRI 127

  Fly   335 KEIESHFGSGVASYFTFLRWLMWVNIMIAIPLVAFVIGPEY-----FATKHGETDPRKRMSDPEA 394
            |:|||||||||||||.|||||..:||::.:...|||:.||.     |.:...:|.||::::.
Mouse   128 KKIESHFGSGVASYFIFLRWLFGINIVLTVMTGAFVVLPELIAGQPFGSTASKTIPREQITS--- 189

  Fly   395 RVAGNLFTFWEFEGYLKYSPMFYGYYSSTSGISTSGYKLPLAYFLTAVLVYIYSFVATLRKMAEN 459
              |.:|.|.|...|||:||.:|||||.....|..:||:|||||||..:.|:.|||:..|:|||:|
Mouse   190 --AQDLDTVWSLGGYLQYSVLFYGYYGRERRIGRAGYRLPLAYFLVGMAVFAYSFIVLLKKMAKN 252

  Fly   460 SRNSKLSSKDDECVFSWKLFTGWDFMIGHAETAHNRIASVVVGFKEALLEEAEKKKDNRNWRV-I 523
            ||.|..|:.::...|.|::|..||::||:.|.|.::.|:::...:||:|||.|||| |:|..| :
Mouse   253 SRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAILNSIREAILEEQEKKK-NKNMAVTV 316

  Fly   524 LQRILVNILVMGLLGLSGA--TVVLLVNHSEDLAKHDNWLS---RNAVNVTMTLLSFFLPMIFEA 583
            ..||:.||||  ||.|:|:  .:..:|:.|:.|.:....|:   :|.|:|.::|::...|..|:.
Mouse   317 CLRIIANILV--LLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMLAPSAFDL 379

  Fly   584 LGLFENWHPRQQLRLQLARIMILNMLNLYSLMFSFIYKINSKEKPLQMLKLENETNTMELKNLLS 648
            :...|.:|||..||.||||:::|.:.|||||:.:.:.|:||
Mouse   380 IAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNS------------------------ 420

  Fly   649 SIEALRAMTPTTSLYGESTSDGLFDDSTSTATWGEDGGGLFSTTAAAALISTTVQRLKCYNMTVK 713
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   714 CSKLRRNIISGKHLATTLMVLNLTTPAMVPPTLPTTLPTTFPTTLPTTLPTTLPTALPTTLPTTL 778
                                :|:
Mouse   421 --------------------MNI------------------------------------------ 423

  Fly   779 PTTLPSTLATTTATTSSIWSTTEETSPTTTTTSPWTTLPPSTTTTEATTTTERATTTTEATSTTT 843
                                   |.:.|...||.|...|
Mouse   424 -----------------------EEAATKNITSHWADAP-------------------------- 439

  Fly   844 LKITTAEINSTLSDTTKPLGKSIDTEIPNSTTNSATLSTIPATLNTTNLPLNSTTKLTTTTSTEK 908
                                           |.||| .|:|
Mouse   440 -------------------------------TFSAT-RTVP------------------------ 448

  Fly   909 PQGEDNFIYTTGEDEGSYDYGSDSTSDAPDNNSYSDITDYSSEPSEIEDFDEQESTDQADDPLAK 973
                         :||
Mouse   449 -------------EEG------------------------------------------------- 451

  Fly   974 VLEQLDENETKGRRKRALAESPFFTSKYSRRHRNESAVSAGQPRETTESVNATPSRWPFNWASFR 1038
                                                                   :||
Mouse   452 -------------------------------------------------------QWP------- 454

  Fly  1039 QTTPRTTTTRRVPSGILTKEEWERLRRLRGRITTTTSTSTTSTTTRRPRWRYRTTTTELTSTTEE 1103
              ||        .||       ..|||         :|||         |....|:. |||.|..
Mouse   455 --TP--------GSG-------AELRR---------NTST---------WVVEETSF-LTSITPH 483

  Fly  1104 ESSTTESSTDSSSPGSTTNAFDSSSSTTEEDEYTTTEGSENRPYYVGYVDISEMGSTIYYDGDSE 1168
                                               |:.::..||..|
Mouse   484 -----------------------------------TKANKTVPYMQG------------------ 495

  Fly  1169 FLEECVITICPKGDDFFGSTTESPDSTTQSSDSKQLTTVKLTPLERKQKRLKEVQLAIKQIQTNL 1233
                      |:|
Mouse   496 ----------PQG---------------------------------------------------- 498

  Fly  1234 TTMCWETSLGQELSKVIVFDGLMSIVAPLCIDFLRALFVRYVNQNWCWDMEKTFPQYGDFKIAEN 1298
              .||||.:|||:.|:.|.|.|.::.:.|.|||.|.|||||::..||||:|..||:||:||||||
Mouse   499 --QCWETYVGQEMLKLSVIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAEN 561

  Fly  1299 ILTLINNQGQVWMGIFFSPGLVLINLVKLMIMMYFRSWIVLTCNVPHEVVFKASKSNNFYLSLLL 1363
            :|.|:.|||.:|||.||||.|...|::||:.:||.|||.||||||||:.||:||:||||||::||
Mouse   562 VLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLL 626

  Fly  1364 TMLFLCVLPVGYAIVWLRPSWHCGPFSEYNRIAEFITNTTRNALPKQLHEPLDYLTSSSTVIPLL 1428
            .|||||:||..:|||..:||.:|||||...:|.:.::.|..|..|...|..:.:::|...::|.:
Mouse   627 FMLFLCMLPTIFAIVHYKPSLNCGPFSGQEKIYDIVSETIENDFPTWFHAVVGHISSPVVILPAV 691

  Fly  1429 LLLILIIYYLVSLTGALREANQDLRTQLQKEREEERKKIFKVPEVKQAEPTATTLTNRWRKVLEA 1493
            |||.::||||.|:..:|:.::|.||.|:|..|.|::||:.::.|       |..:.:..|:...|
Mouse   692 LLLFMLIYYLQSIARSLKLSSQQLRMQIQNARSEDKKKVAQMVE-------ALAIPSDARQAGSA 749

  Fly  1494 SSPVTPTQPPDFDTEEYKNQARKELISRIM------KKALRKGSATSDEDS-FVRRDDDDTDTEH 1551
            :           :.|..:|...|.|.:||.      |:.|:.....|...| ::....::....:
Mouse   750 T-----------EAESSENSKPKTLQARIQTHEESSKRLLKDSDLISQLSSVYMATSPNNGHMLN 803

  Fly  1552 QDSLPHDEEAKDKRFGLSRLQQIRRTRKPSLVDIVQIAKQERARAGSIVAGTSSSGTGNFPIKET 1616
            .|||....         .|::.|.|:...|      ..:..|.....::.|:.|.     |.::|
Mouse   804 FDSLSSKS---------LRMEAITRSLPQS------PGQGSRDPCSPLLDGSRSR-----PEQDT 848

  Fly  1617 --HPKSRFKVEKHERKDRG-----SMKDKKDTRHRQSPQQQQQP--PPY-----ESPKDNEHDP- 1666
              ||........:..|:|.     ..:..||.|.....::..||  ||:     .:...::|.|
Mouse   849 NRHPHRPCSSTSNLHKNRSCSSVTQTQPLKDVRSEPLSRKDFQPISPPFCGSGVSTLMTHDHSPR 913

  Fly  1667 ----------DTNSRIVSASLLRRH-KEQAEGEEPPTTPDAPQ-----TPNSPVEPVEQALEEST 1715
                      |::.:...|....|| |..|.|:.....|...|     .||.|..|  |..||
Mouse   914 APRYYVVNERDSHKKTHRAFWPERHFKIDALGDIVELYPRNVQQYMSWVPNQPCSP--QLSEE-- 974

  Fly  1716 PETPTLAKSKFHIVDEKKPPPHEVEDKPLPTPKESGSGGGSLGKFKFRKHKFKSNNVAAVKPEPE 1780
             |...|.:.    :.:...|...:.|.|..:...:|..              ..||....|.:..
Mouse   975 -EEEMLRRD----LVQWSIPASSLTDLPRSSCFYTGDR--------------SENNTRDPKYQRR 1020

  Fly  1781 VF------KFDERSVERSSDV---PATHAAEYLNN----------EPSGTEEQDRSLPSPTPSQG 1826
            |:      .|::: :||.:.|   |.:...:|..:          |||.||....|..|.:..|.
Mouse  1021 VYYRSGDNSFEDQ-LERPTFVHRKPRSRNGQYPQHALKARVKAKFEPSFTESDSVSAASSSDHQN 1084

  Fly  1827 QGHHQRQLSVLSRQGR-----KKIGNLLALVREAVNLKKDDV 1863
            ..:.| .|.|:|.|||     .::|...|..|:.:....:|:
Mouse  1085 SNNDQ-YLHVMSSQGRFPRSASQLGRRKAKSRQVLPTDLNDL 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmc	NP_001303362.1	TMC	1237..1352	CDD:462275	67/114 (59%)
Tmc3	NP_808363.3	TMC	500..615	CDD:462275	67/114 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..774		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..893		15/84 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	999..1019		4/33 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1059		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1116		5/18 (28%)